Mechanism Of System Research Articles

Formation of strategic partnership between the state, employers and trade unions to ensure the workforce capacity of the post-war industrial recovery: condition and prospects

Abstract The authors of the article justified the need for the formation and implementation of a strategic partnership between the state, employers and trade unions in order to create favorable conditions for ensuring workforce capacity for the post-war recovery of Ukraine's industry. The author's research is based on the structural-functional approach. Its purpose is to identify and justify the possibilities of forming a strategic partnership between the state, employers and trade unions to ensure the workforce capacity of the post-war industrial recovery based on the analysis of the condition and specifics of their activities and interaction under conditions of full-scale armed aggression. The content and logic of the author's research included the following: 1) assessment of the general state of the domestic industry, key challenges and threats affecting it under conditions of martial law; 2) identifying the dynamics of changes in the supply of labor to industry, existing sharp contradictions, as well as positive changes in the recovery of certain branches of industry; 3) determination of key guidelines for the renewal of the system of institutions and mechanisms that regulate employment in industry and affect the justification of priorities regarding the processes of formation of workforce capacity for the recovery of Ukrainian industry; 4) analysis of the current state of the system of collective agreement regulation, the activities of key partners of the partnership, the functions of the National Tripartite Socio-Economic Council and the activities of specialized state structures regarding the prospects of personnel support for the recovery of Ukrainian industry; 5) conceptualization of the vision of the formation of a strategic partnership between the state, employers and trade unions to ensure the workforce capacity for the post-war recovery of industry, with the definition of priority tasks. It is substantiated that the modernized system of social dialogue is the basic tool for achieving mutual agreement and synergy in the implementation of strategic partnership in Ukraine. This system should be aimed at solving strategically important issues regarding the stability of the national economy, ensuring the workforce capacity for the post-war development of the industrial sector. Key guidelines for updating the system of relevant institutes and mechanisms are: 1) focusing on the concept of decent work, following the principle of the International Labor Organization (ILO) – 'build back better', as well as not focusing on the indicators of the pre-war level, but rather on achieving a qualitatively new level of functioning of the economy, social labor sphere, Ukrainian industry; 2) implementation of the European integration course and ensuring compliance of the system of relevant institutes in the industry with EU requirements and standards. Keywords strategic partnership, post-war recovery, workforce capacity of Ukrainian industry, trade unions, employers, state, social dialogue

Influence of School Administrators’ Transformational Leadership on the Innovation Ability of University Teachers

With the development of higher education, the improvement of teachers' innovation ability has become an important issue. This article aims to explore the impact of transformational leadership of school administrators on the innovative ability of college teachers. Through literature review and empirical research, we analyze the difficulties and challenges faced by school administrators in improving teachers' innovation capabilities and propose effective countermeasures. The results show that transformational leadership demonstrates significant value and positive impact in higher education. Its core characteristics include being visionary, inspiring, focusing on individual and team growth, and driving organizational change. Transformational leadership plays a role in stimulating teachers' innovative thinking, promoting organizational changes, creating a positive organizational culture, and establishing effective communication mechanisms, which effectively promotes the improvement of university teachers' innovative capabilities. The composition of teachers' innovative ability involves three aspects: teaching, scientific research and practice, and is affected by multiple factors such as individuals, organizations and society. In order to improve teachers' innovation ability, these factors need to be comprehensively considered and targeted measures and support need to be adopted. There are differences in the perception and identification of transformational leadership among university teachers, which may be related to factors such as personal background, organizational culture and external environment. Strengthening communication and exchanges with teachers, establishing a fair and transparent incentive mechanism and evaluation system, providing sufficient resources and support, and advocating an open and inclusive organizational culture are key measures to enhance perception and recognition. In different subject areas and types of universities, the application of transformational leadership needs to be tailored to local conditions. Develop targeted change strategies based on the different characteristics of science and engineering, humanities and social sciences, and the differences between research-oriented and teaching-oriented universities. Finally, transformational leadership has a positive impact on teachers’ professional development, including promoting professional growth, increasing career satisfaction, and increasing intention to stay. However, during implementation, attention should be paid to possible differences in effects due to differences in context and conditions. Therefore, higher education institutions should strengthen the cultivation and introduction of transformational leadership to help teachers achieve better development and satisfaction at different levels.

Research on the Development Path and Mechanism of “Double-Qualified” Teachers in Private Universities Under the Background of Digital Transformation

This article explores the development path and mechanism of “double-qualified” teachers in private universitiesunder digital transformation. Through literature review, theoretical analysis, and other research methods, this study conducts an in-depth analysis of the impact of digital technology on the development of “double-qualified” teachers in private colleges and universities and puts forward corresponding strategies and suggestions. Research shows that digital transformation provides new opportunities and challenges for developing “double-qualified” teachers in private colleges and universities. To adapt to this trend, teachers must continuously improve their digital skills, and schools should establish a complete incentive mechanism and evaluation system, strengthen school-enterprise cooperation and the integration of industry and education to promote the comprehensive development of “double-qualified” teachers, and provide a useful guideline for private universities to promote the development of “double-qualified” teachers in digital transformation.

Exosomes: A Cellular Communication Medium That Has Multiple Effects On Brain Diseases.

Exosomes, as membranous vesicles generated by multiple cell types and secreted to extracellular space, play a crucial role in a range of brain injury-related brain disorders by transporting diverse proteins, RNA, DNA fragments, and other functional substances. The nervous system's pathogenic mechanisms are complicated, involving pathological processes like as inflammation, apoptosis, oxidative stress, and autophagy, all of which result in blood-brain barrier damage, cognitive impairment, and even loss of normal motor function. Exosomes have been linked to the incidence and progression of brain disorders in recent research. As a result, a thorough knowledge of the interaction between exosomes and brain diseases may lead to the development of more effective therapeutic techniques that may be implemented in the clinic. The potential role of exosomes in brain diseases and the crosstalk between exosomes and other pathogenic processes were discussed in this paper. Simultaneously, we noted the delicate events in which exosomes as a media allow the brain to communicate with other tissues and organs in physiology and disease, and compiled a list of natural compounds that modulate exosomes, in order to further improve our understanding of exosomes and propose new ideas for treating brain disorders.

Assessment of tourism socio-ecological system resilience in arid areas: A case study of Xinjiang, China

Arid regions hold a prominent position as global tourist destination. However, their ecological fragility and sensitivity to economic and social factors make them more susceptible to various disruptive elements, thereby exacerbating the instability of the tourism socio-ecological system. Consequently, there has been a growing focus on tourism socio-ecological system resilience (TSESR) in arid regions. This study has developed a scientific and universally applicable assessment framework to evaluate TSESR in arid regions, considering the system's process mechanisms and dimensions. The framework encompasses four key domains: resistance, recovery, adaptation, and renewal, further divided into twelve criterion layers. This study conducted a case study in 14 prefecture-level units in Xinjiang, China, from 2010 to 2020. An improved TOPSIS model, Gini coefficient, Kernel density estimation, and Obstacle degree model were employed to investigate the levels, spatiotemporal variations, and obstacle factors of TSESR. The research findings indicate that during the study period, the resilience levels of the 14 prefecture-level cities exhibited an overall upward trend with fluctuations. There are notable spatial disparities, yet these disparities are diminishing. Furthermore, factors such as resource endowment, market potential, economic foundation, industrial environment, and human capital represented common obstacles, while unique regional impediments also existed. The TSESR assessment index system can scientifically and comprehensively evaluate resilience levels, offering an adaptive indicators framework for arid regions. It promotes the development of a resilient tourism socio-ecological system, thereby achieving sustainable tourism development.

Fostering Public Health and Environmental Protection with "Carrots and Sticks": The Role of the Social Credit System in China

Abstract: This article examines China's social credit system (SCS), whose objective is to promote trustworthy and responsible behaviour, by focusing on its impact on corporate behaviour, law enforcement, public health and environmental policy. The authors delve into the mechanisms of the implementation of the system while assessing its effectiveness in achieving these objectives. The authors employ detailed case studies, such as curbing wild animal consumption and enforcing environmental regulations, to highlight the system's innovative credit repair mechanism. The SCS's emphasis on accountability and compliance emerges as a significant driver for public health and environmental protection. Based on the authors' interviews conducted for this article, the SCS's promotion of responsible conduct, which combines legal penalties with social credit measures, has notably fostered positive behavioural changes and societal benefits. This article underscores the potential contribution of the SCS to the public good by emphasising accountability and compliance. Overall, the article contributes to a better understanding of the SCS's implementation and its potential role in fostering a safer, healthier and more sustainable society when administered judiciously.

Vocal and arranging solutions for broadcasting Kuban Cossack folk songs: methodology and practice

The object of the research is performance as a theoretical and methodological basis for the preservation of folk songs in the modern world. The subject of this work is a variety of tools for translating sources through the use of interpretation through vocal arrangements. The purpose of this study is to find performance techniques for comprehending the folklore of the Kuban Cossack song, illustrative popularization of the real listener through a new reading of the original source. In identifying the substantial foundations of song performance, special attention is focused on the music collections of folklorists V. G. Zakharchenko (born 1938), A. D. Bigdai (1855-1909), G. M. Kontsevich (1863-1937), who made a significant contribution to the foundations of the Kuban Cossack folk singing art. Along with this, the analysis of a wide range of vocal arrangements in the practice of professional and amateur vocalists provides a postulation about the ambiguity of interpolation in the formation of an original reading of folklore documents. The theoretical justification of this study is based on the tactics of analyzing endemic folklore singing concepts in the context of the art history dynamics of modern research. The methodological core of the work identifies the elements of preserving traditional performance through the vocally processed embodiment of Kuban Cossack folk songs. The author's direction has been developed in the complex of the constituent elements of the arranging performance, based on the personality of the vocalist, containing an individual interpretation of the performing plurality. The performing techniques of folklore Cossack sources has been formed. Exceptional accents are identified in the analysis of musical folklore sources (selectively) to establish new technical characteristics of performance. The scientific novelty of the research lies in the genesis of Cossack culture for the author's constructive orientation of ways to preserve and transform musical material to a modern listener. The characteristics of the song material according to the genre-performing component, expressed by the system of mechanisms of performance by vocal-performing solutions, are revealed. The derived orientation of the translation mechanisms opens up new facets of the performance of Kuban Cossack folk songs for the preservation of traditions with multifaceted options for the transformation of folklore documents for subsequent generations.

Analysis Of The Effectiveness Of Government Communication And Empowerment For Traditional Fishpond Farmers On The North Aceh Coast

Research to determine, describe and analyze the effectiveness, transparency and accuracy of government communication and empowerment for Traditional Pond Farmers on the coast of North Aceh, Aceh province. Utilizing all communication media effectively, creatively and innovatively in strengthening partnerships and collaboration; government, pond farmers, coastal institutions and other stakeholders. Becoming a new paradigm and perspective in development and empowerment with the spirit of voicing the voiceless. In revealing the socio-economic capital of traditional pond farmers. The presence of government communication, development communication and empowerment to contribute to the development and empowerment process, diffusion of innovation and communication technology. The phenomenon of helplessness of traditional pond farmers in North Aceh is an illustration of the still weak effectiveness of government communication, development communication, empowerment and human-centered social change. This research uses a phenomenological paradigm with theoretical foundations and concepts from the perspective of government communication, social development communication, empowerment communication, communicative action, social welfare, social capital, local wisdom, coastal areas and traditional pond farmers. Data is collected through interviews, observation, focus group discussions, literature review or documentation. The results of the research show that changes in the mindset of traditional pond farmers will lead to different behavior patterns than before. In this process of change, it can be seen that there is a self-help process to get out of the stigma of being poor and marginalized. The development and empowerment process should show empowerment, participation, collaborative communication that can lead to a condition of life for pond farmers based on mutually agreed values, norms, customs, culture and local wisdom capable of strengthening social welfare and social capital. Development and empowerment must be understood as a process with multiple dimensions, involving major changes in social structures, social institutions, attitudes, minimizing inequality, marginalization and absolute poverty. There needs to be a paradigm shift from a capitalist market mechanism system to upholding nationalist values ​​with human- centered development practices. Including strengthening togetherness, harmonization, solidarity and strengthening collective self-empowerment. So that the effectiveness of government communication, development and empowerment of traditional pond farmers must be prepared based on initiative, participation, orientation to needs, potential and capabilities while still paying attention to the institutional dynamics therein.

Non-contact electromagnetic controlled metamaterial beams for low-frequency vibration suppression

To address the challenge of suppressing extremely-low frequency vibration and noise in precision instruments and equipment, a novel non-contact metamaterial beams is proposed in this paper. The resonators of the metamaterial beams integrate negative stiffness mechanism and electromagnetic damping tuning system. Based on the magnetic dipole theory and the electromagnetic induction law, the mechanical model of magnetic resonator is established. The band structure and transmission spectrum of the metamaterial beams are obtained by transfer matrix method. Besides, the results of numerical simulations are used to verify the accuracy of theoretical results. The result shows that the negative stiffness can be controlled by nonlinear magnetic force among the magnets. Based on this mechanism, the bandgap frequency can be reduced to a minimum of 50Hz. Then, the method of combining electromagnetic damping and negative impedance circuit is proposed to form a tuning system which can reduce the initial frequency of the bandgap to 4Hz. Interestingly, the proposed bandgap control mechanism achieves the extremely-low bandgap while broadens the bandwidth relatively, which overcomes the deficiency of traditional quasi-zero-stiffness metamaterials that reduce the bandgap frequency while causing the bandwidth to narrow. This study is expected to provide valuable ideas for the application of metamaterials in the field of low-frequency vibration and noise reduction.

Infusion of individual style into the professional activity of a trainer

This work analyzes the infusion of individual style into professional coaching activity, which consists of two mutually related components: directly sports activity (development of rocine bones, training and thorough This is a technical and tactical activity, the participation of both sides and the pedagogical activity of the coach as a mentor , teacher, teacher (influence on the formation of character, valuable attitudes, formation of specialness). In addition, the use of motor physical exercises should be considered only as material for the activity-practical dialogue of the coach and the athlete and act as a means of self-realization of the individual with the coach's main attention being directed to the development of the individual, as a single social and natural, spiritual and physical, and not only to the formation of the organism , as a system of impersonal physiological and biological mechanisms.
 In the process of research, an analysis of the content of coaching activities, which is carried out within the framework of physical culture and sports as an element of human culture as a whole; the main professional qualities and character traits of a coach are determined for obtaining a positive result when developing an individual style in one's professional activity (kindness and attentiveness to students, sociability, justice, honesty, principledness, hard work, sacrifice, professional talent, high morality, broad outlook and erudition, spiritual culture, optimism, emotional stability, competence, professionalism, endurance, perseverance, compassion, patience and kindness, creativity, intuition, sense of humor and others).

Electrospherization of genistein@DNA core-shell nanospheres as a drug delivery system and theoretical study of the release mechanism

Encapsulation of poor water-soluble drug was considered as one of the widely used approaches to overcome such obstacle. The goal of this research was in situ encapsulate the hydrophobic genistein (GEN) during the electrospherization (Es) of deoxyribonucleic acid (DNA) nanospheres as a delivery system with appropriate drug release properties. The prepared nanospheres (free GEN sample; Es DNA and GEN loaded DNA; Es GEN@DNA) were characterized using uv–visible spectroscopy (UV–vis), transmission electron microscope (TEM), zeta potential, Fourier transform infrared spectroscopy (FTIR), x-ray diffraction analysis (XRD), and stability test. In addition, the drug encapsulation % was studied, the drug release efficiency was recorded and theoretically visualized to understand the mechanism and kinetics of GEN drug release. The results revealed that GEN was successfully encapsulated during the DNA electrospherization as a core (GEN)/shell (DNA) like structure with a wonderful stability against time. The UV–vis patterns and their deconvolutions introduced that the emerged peak around 372–500 nm of Es GEN@DNA nanospheres has an area under curve larger than that of the free GEN sample. Zeta potential value decreased from −17.4 to −14.3 mV. In addition, TEM images confirmed the formation of a core/shell structure with average size 109.2 nm. XRD pattern of Es GEN@DNA revealed that GEN lost its crystalline phase, which indicated the incorporation of the drug. On the other hand, %Encapsulation of GEN within DNA nanospheres was found to be 89.62%. Es GEN@DNA release profile explored that the well entrapped GEN within the DNA nanospheres could be a promising for sustained drug release. Besides, the dilemma of using a fractal or fractional kinetics model was overcame by introducing a general fractional kinetic equation that involves a time-dependent rate coefficient, which introduced that the solution of the fractional kinetic model can fit the release data profiles.

Autonomy Governance Transformation in the Higher Education Institutions Towards the Typical Models in Vietnam

Based on existing studies on university autonomy, particularly university autonomy in Vietnam, along with the examination of legal documents about the higher education system in Vietnam, and the findings from field surveys and surveys conducted on various higher education institution websites, this article aims to elucidate the autonomy model of higher education institutions. In doing so, it highlights the current state of autonomy in Vietnamese higher education. It identifies the dimensions missing from previous studies concerning university owners, both at the institutional and practical levels. The article outlines five major autonomy models for higher education institutions, which are formed by a system of mechanisms and policies in higher education. For each of these models, the research considers, analyzes, and evaluates the level of autonomy in terms of decision-making rights and self-responsibility across three fundamental areas of the university: organizational and personnel autonomy, academic autonomy, and autonomy in finance and facilities.

Механізми публічного управління у сфері охорони здоров’я в Україні: стан і системотворення

Public administration in the field of healthcare is carried out using certain tools (methods, techniques, operations, algorithms of actions, procedures and techniques of action, management technologies, communication strategies, etc.). The composition of the mechanisms of public administration in the sphere of healthcare is proposed, which is determined by the results of the analysis of the content and results of the medical reform in Ukraine. The aim (purpose of application), features of action, limitations and degree of completeness of public administration mechanisms in the field of healthcare in Ukraine are considered. Further improvement of public administration in the field of healthcare in Ukraine lies in the plane of system creation of its instrumental base. The system of public administration mechanisms in the field of healthcare is a set of various mechanisms, the simultaneous action of which in terms of interconnection and interdependence allows to ensure high-quality public administration in the most important socioeconomic sector of the country, which is healthcare. The features of the system of mechanisms of public administration in the sphere of healthcare are characterized. The formation of a system of public administration mechanisms in the field of healthcare in Ukraine should have a fundamental basis, which is formed in the form of appropriate conceptual foundations. The conceptual foundations of the formation of the system of public administration mechanisms in the field of healthcare in Ukraine contain a set of attitudes, principles, provisions, guidelines and vectors of action of state institutions, combined into constructs, the reliance on which will allow the formation of such a really effective system. The creation of a system of public administration mechanisms in the field of healthcare in Ukraine is important for improving the quality of public administration, and therefore great attention should be paid to this process.

PARAMETRIC OPTIMIZATION OF FREQUENCY-CONTROLLED START-UP OF DYNAMIC SYSTEM "TROLLEY-LOAD" OF TOWER CRANE TROLLEY MOVEMENT MECHANISM

In the scientific article, a scientific and applied problem is solved, which allows to minimize the dynamic and energy parameters of the frequency-controlled drive of the dynamic "cart-load" system of the tower crane flight change mechanism during the transient start-up mode. To solve this problem, the existing mathematical model of the change in the departure of the load was used, which was supplemented by a mathematical model of the motion of an asynchronous electric drive in time. The parameters for setting the frequency-controlled drive are used: the duration of the increase in the frequency of the supply voltage, the initial supply voltage of the electric motor and the type of characteristic of the increase, up to the nominal value, of the frequency of the supply voltage. The maximum values of the torque in the elastic coupling, the effort in the traction rope and the power in the electric drive were used as optimization criteria. Using the modified RING-ROT-PSO optimization method, the rational values of the given parameters and the type of characteristic are established, in which the minimization of the studied criteria is observed. A comparative analysis of discrepancies when varying different types of characteristics was performed, which proved the adequacy of the performed parametric optimization. Parametric optimization of the frequency-controlled electric drive was carried out, which made it possible to minimize the amount of undesirable dynamic (torque in the elastic coupling and force in the traction rope of the truck drive) and energy (power in the drive) characteristics of the dynamic "cart-load" system of the mechanism for changing the departure of the tower crane. A modified method of swarm particles (RING-ROT-PSO) was used for optimization. It was established that the minimum values of dynamic criteria when using optimal characteristics (linear and 2S-shaped) in the range of 6.9...27.9% are smaller than when using non-optimal (U-shaped and S-shaped) characteristics. The minimum value of the energy criterion when using a U-shaped characteristic is 30.4% less than when using an S-shaped characteristic. Therefore, in order to minimize the amount of unwanted dynamic indicators during the frequency-controlled start of the dynamic system "cart-load" of the departure change mechanism, it is desirable to use linear and 2S-like characteristics, and to minimize the amount of unwanted energy indicator, U-shaped. At the same time, it is also necessary to rationally set parameters t1 and U0.

Neural coordination of bilateral hand movements: evidence for an involvement of brainstem motor centres.

Bilateral hand movements are assumed to be coordinated by a neural coupling mechanism. Neural coupling is experimentally reflected in complex electromyographic (EMG) responses in the forearm muscles of both sides to unilateral electrical arm nerve stimulation (ES). The aim of this study was to examine a potential involvement of the reticulospinal system in neural coupling by the application of loud acoustic stimuli (LAS) known to activate neurons of this system. LAS, ES and combined LAS/ES were applied to healthy subjects during visually guided bilateral hand flexion-extension movements. Muscle responses to the different stimuli were evaluated by electrophysiological recordings. Unilateral electrical ulnar nerve stimulation resulted in neural coupling responses in the forearm extensors (FE) of both sides. Interestingly, LAS evoked bilateral EMG responses that were similar in their configuration to those induced by ES. The presence of startles was associated with a shift of the onset and enhanced amplitude of LAS-induced coupling-like responses. Upon combined LAS/ES application, ES facilitated ipsilateral startles and coupling-like responses. Modulation of coupling-like responses by startles, the similarity of the responses to ES and LAS, and their interaction following combined stimulation suggests that both responses are mediated by the reticulospinal system. Our findings provide novel indirect evidence that the reticulospinal system is involved in the neural coupling of hand movements. This becomes clinically relevant in subjects with a damaged corticospinal system where a dominant reticulospinal system leads to involuntary limb coupling, referred to as associated movements. KEY POINTS: Automatic coordination of hand movements is assumed to be mediated by a neural coupling mechanism reflected by bilateral reflex responses in forearm muscles to unilateral electrical arm nerve stimulation (ES). Loud acoustic stimuli (LAS) were applied to assess a potential involvement of the reticulospinal system in the neural coupling mechanism. LAS evoked a bilateral reflex response in the forearm extensors that was similar to the neural coupling response to ES, and which could be separated from the acoustic startle response. Combined application of LAS and ES resulted in a facilitation of startle and coupling-like responses ipsilateral to ES, thus indicating an interaction of afferences from both stimuli. These novel findings provide indirect evidence that the reticulospinal system is a key motor structure for the coupling of bilateral hand movements.

Implementation Mechanism of Industry-Education-Creation Mixed Ownership Industrial College Based on AHP Fuzzy Evaluation Model

Abstract The management of modern industrial colleges is the deepening and developing the fusion of industry-teaching-creation and school-enterprise cooperation talent cultivation mode, which has strategic height and practical significance. This paper establishes the evaluation index system of the implementation mechanism of industrial colleges based on BSC theory. It creates the implementation mechanism model of mixed teaching and learning in industrial colleges. Combining qualitative and quantitative analysis, the hierarchical and fuzzy hierarchical analysis methods are used to construct the hybrid teaching quality evaluation model of industry-teaching-creation. Then the weights of the evaluation indexes of the implementation mechanism of industrial colleges are calculated. The industrial colleges of college A and college B are selected as the research objects to comprehensively evaluate the implementation effect of their mixed industry-teaching-creation teaching. The optimal model is determined by calculating the comprehensive scores of the five industry-education-creation hybrid teaching implementation mechanisms. The study shows that the highest weight of finance is 0.333. The total scores of college A and B are 80.56 and 83.33, and college B has a higher level of industry-teaching-creation hybrid teaching implementation mechanism. The composite score of the co-constructed science and technology park model is 0.233, the optimal mixed teaching implementation mechanism of Industry, education and creativity.

Information security in the Union State: the universal legal dimension

The subject of the study forms a set of legal norms of normative legal acts of the Russian Federation, the Republic of Belarus and the interstate association of the Union State of the Russian Federation and the Republic of Belarus, international treaties(agreements) regulating public relations in the field of information security, law enforcement practice, foreign experience of legal regulation, as well as provisions theoretical interdisciplinary research in this field. The object of the study is public relations related to the legal provision of information security in the Union State. The Russian Federation and the Republic of Belarus in the context of new challenges and threats, as well as digital transformation and geopolitical changes. The analysis indicates a certain experience of scientific research in this field. At the same time, in the context of significant changes in socio-economic and foreign policy conditions, new challenges and threats, multi-vector scientific research in the information and legal sphere is necessary. The methodological basis of this study is a system of modern general scientific and private law methods. The study of the formation, development, place and role of the legal provision of information security of the Union State of the Russian Federation and the Republic of Belarus was conducted using the following general scientific methods: analysis and synthesis, abstraction and modeling, generalization, description, etc. The main conclusions of this study were the following proposals, it is necessary to develop and approve the conceptual framework for the legal provision of information security for the development of regional interstate cooperation within the framework of the Union State of the Republic of Belarus and the Russian Federation. This is important for solving the tasks of ensuring national and international information security, implementing agreements within the framework of regional interstate associations and further forming a system of universal public law mechanisms for ensuring information security. At the same time, the strategic legal acts of the Union State in the field of information security are dynamic in nature due to changes in social and political relations, including at the international level. There is a growing tendency to perceive the information space not only as an area requiring the use of exclusively protective measures of influence, but also involving active offensive measures to the extent necessary to protect national interests.

Analysis on the Construction and Realization of Cultivation Mechanism of Young Marxists in Colleges and Universities in the Internet Era

Abstract Based on the design of functional orientation, the training mechanism of young Marxists was innovated by combining network characteristics. Forty experts from enterprises, colleges, and universities were selected, and the Delphi method was applied to finalize the evaluation index system of the Marxist cultivation mechanism. Based on the evaluation index system, the Marxist cultivation mechanism’s evaluation model was constructed using principal component analysis. The results show that the weight coefficient of the effect index Q16 of the Marxist cultivation mechanism is 0.32415, and the weight coefficient of the innovation index Q8 of the Marxist cultivation mechanism is 0.20381. The extracted principal components can effectively explain the key factors of the cultivation mechanism. This study advances the new development of the Marxist cultivation mechanism in terms of epochal, scientific, and systematic, which is of great significance to the development of Marxist education in colleges and universities.

Serum microRNA-223 as a potential biomarker for allergic rhinitis and its correlation to eosinophil-derived neurotoxin

Allergic rhinitis (AR) is a global health problem. It is an inflammatory condition defined by a malfunction of the immune system's regulatory mechanism. MicroRNA-223 (miRNA-223) has been linked to the modulation of AR in the last few years. The goal of this study was to determine whether miR-223 can be utilized as a potential biomarker for diagnosis of AR, and whether it correlates with the total nasal symptom score (TNSS) along with serum interleukin-17 (IL-17), interleukin-4 levels (IL-4) and eosinophil-derived neurotoxin (EDN). This study included 76 adult participants, consisted of 38 AR patients and 38 apparently healthy controls. Serum levels of miR-223 were assayed using real-time PCR. The levels of EDN, IL-17 and IL-4 in the serum were determined using an enzyme-linked immunosorbent assay. The optimal cutoff value for the analyzed factors to diagnose AR was determined using a receiver operating characteristic curve analysis (ROC). The demographic features (age and gender) of the two study groups were matched. Patients with pollen-induced AR had significantly higher levels of miR-223 in their serum compared to the controls (median = 3.82; median = 1.03, respectively, p < 0.001). In AR cases, a significant positive association was observed between miR-223 expression level and TNSS (r = 0.492, p = 0.002), EDN serum level (r = 0.427, p = 0.008), IL-4 serum level (r = 0.341, p = 0.036) and IL-17 serum level (r = 0.324, p = 0.047). MiR-223, at a cutoff value of 1.18, had a sensitivity and specificity of 94.9 % and 92.5%, respectively. In conclusion, miR-223 expression is significantly greater in blood of AR patients. There is a significant association between miR-223 and clinical severity of AR, each of IL-17 and IL-4 as well as EDN. Therefore, miR-223 may be employed as an effective biomarker for AR diagnosis.

Selective oxygen reduction reaction: mechanism understanding, catalyst design and practical application.

The oxygen reduction reaction (ORR) is a key component for many clean energy technologies and other industrial processes. However, the low selectivity and the sluggish reaction kinetics of ORR catalysts have hampered the energy conversion efficiency and real application of these new technologies mentioned before. Recently, tremendous efforts have been made in mechanism understanding, electrocatalyst development and system design. Here, a comprehensive and critical review is provided to present the recent advances in the field of the electrocatalytic ORR. The two-electron and four-electron transfer catalytic mechanisms and key evaluation parameters of the ORR are discussed first. Then, the up-to-date synthetic strategies and in situ characterization techniques for ORR electrocatalysts are systematically summarized. Lastly, a brief overview of various renewable energy conversion devices and systems involving the ORR, including fuel cells, metal-air batteries, production of hydrogen peroxide and other chemical synthesis processes, along with some challenges and opportunities, is presented.