Objective To observe the effect of nursing intervention on treatment effect and constipation symptoms of patients with brain infarction. Methods From October 2009 to October 2010, 98 cases patients with brain infarction were randomly classified into the control group and the observation group with 49 cases in each group. The control group was treated with normal nursing and the observation group received nursing intervention. The effect and the changes of constipation symptoms between the two groups were compared. Results Compared with pre-nursing, the scores of ADL in two groups were significantly improved after nursing. Moreover, the scores of ADL in the observation group were significantly higher than those in the control group. The scores of difficult defecation, characteristics of feces, feeling of bearing down was lower than those of the control group. Conclusions Nursing intervention for patients with brain infarction can improve the clinical effect and constipation symptoms, which can be applied in clinic. Key words: Nursing intervention; Brain infarction; Constipation