Abstract
Objective To research the influence of nursing intervention on platelet activation markers PAC-1 and CD62p during a chemotherapy cycle in non Hodgkin' s lymphoma (NHL) patients. Methods 30 NHL cases were randomly divided into two equal parts including simple chemotherapy group (simple group) and chemotherapy plus vein nursing intervention group (intervention group), and 15 healthy subjects were selected as control group. PAC-1 and CD62p expressions were detected by flow cytometry (FCM) at d0, d3, d7 and d14 during a chemotherapy cycle respectively. Results The expressions of PAC-1 and CD62p in disease group were significantly higher than those in control group (5.63 ± 1.68% vs 3.43 ± 1.07%, t =5. 323, P 0. 05 ). Conclusions Nursing intervention may restrain platelet activation efficiently in NHL patients during chemotherapy. Key words: Non-Hodgkin' s lymphoma; Platelet activation; Flow cytometry; Nursing intervention
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