Lotion Research Articles

PENGARUH KESADARAN HALAL, LABEL HALAL, DAN BAHAN PRODUK TERHADAP KEPUTUSAN PEMBELIAN ULANG BODY LOTION SCARLETT WHITENING PADA MAHASISWA MUSLIM FAKULTAS EKONOMI DAN BISNIS UNIVERSITAS JEMBER

The study was conducted to test and analyze the partial and simultaneous effect of halal awareness, halal labels, and product ingredients on the decision to repurchase Scarlett Whitening body lotion among Muslim students at the Faculty of Economics and Business, University of Jember. The population is students of the Faculty of Economics and Business, University of Jember who have active undergraduate status and have purchased Scarlett Whitening body lotion . This study determines the number of samples through purposive sampling method totaling 100 samples. By using multiple linear regression analysis method. The results of the t test show that t count on the halal awareness variable is 2.157 with a significance value of 0.034, which means that halal awareness has a significant effect on repurchasing decisions. The results of the t test show that the t count on the halal label variable is 2.051 with a significance value of 0.043, which means that the halal label has a significant effect on repurchasing decisions. The results of the t test show t count on the variable product ingredients 2.392 with a significance value of 0.019, which means that product ingredients have a significant effect on repurchasing decisions. Whereas the results of the F test simultaneously have a significant influence on the decision to repurchase Scarlett Whitening body lotion for Muslim students at the Faculty of Economics and Business, University of Jember.

The Training for Triharjo Village’s Stockbreeders on Production of BSF Larve’s Oil as Potential Cosmetic Raw Material

Indonesia has seen a rise in Black Soldier Fly maggots. Maggot farming offers great economic diversification. BSF (maggot) larvae may eat many organic materials, making them special. This helps bioconvert organic waste, which can damage the environment and harm people's health if not treated properly. Protein-rich maggots are animal feed ingredients. Serious maggot cultivation can create new jobs. This maggot culture has a hidden gem that must be removed. Maggot oil studies still produce animal feed. Maggot oil is antibacterial and emollient, making it a cosmetic and medicinal ingredient, according to worldwide studies. Cosmetics use fats as viscosity enhancers or emulsifiers. As a proof of concept, BSF larvae fat will be used in hand cream compositions to show its potential in organic waste processing, animal feed, and health and beauty additives. Naturally, national and international scientific journals and social media have not broadly shared this information and talents. The Cosmetic Engineering study program's Community Service Team shares information, insights, and talents to connect research, education, and community applications. The ITERA Cosmetics Engineering team will train maggot breeders in Triharjo village to increase maggot production and diversify maggot products to boost sales.

The impact of body lotions on the skin microbiome and ceramides

The impact of body lotions on the skin microbiome and ceramides

ESG approach in the valorization of cocoa (Theobroma cacao) by-products by subcritical water: Application in the cosmetic industry

In this research valorization potentials of cocoa hull extracts in cosmetic industry, following Environmental, Social, and Governance (ESG) criteria, have been investigated and reported, presenting increased value of this biowaste. The extracts of cocoa hull obtained by subcritical water were characterized in respect to chemical composition and certain bioactive properties, and were used to develop functional cosmetic formulation. In this work cocoa hull of cocoa beans originating from different geographical locations (Ivory Coast, Ghana, Togo, Grenada) were extracted by subcritical water to obtain functional extracts rich in valuable compounds. The extracts were characterized in respect to their total proteins (10–27%), total phenols (37–45 mg GAE/g) and total flavonoids (14–21 mg RE/g) contents. In addition, the minerals K (41–60 mg/100 g), Na (0.78–1.17 mg/100 g), and Ca (2.47–5.94 mg/100 g) were also quantified. Antiradical activity against DPPH (IC50 ∼ 11–13 μg/ml) and ABTS (IC50 ∼ 7–9 μg/ml) radicals, as well as total antioxidant activity (∼14–20 mg EAK/100 g DE), were determined and compared for all extracts. The extract with the highest antioxidant and antiradical activity was used for the formulation of a functional cosmetic product – a day cream with sun protective properties and added qualities. The prepared facial cream was analysed in respect to basic quality parameters for cosmetic products, proving the safety of the newly developed product based on subcritical water extracts of cocoa hull. The application of subcritical water extraction, as a green technology, can significantly enhance the ESG development in the cosmetic industry.

Clinical studies in Chinese subjects investigating the tolerance and soothing efficacy of a cream and balm containing 4-t-butylcyclohexanol on the sensitivity of facial skin.

Asian subjects are particularly prone to skin sensitivity. We developed a facial cream and balm containing 4-t-butylcyclohexanol to provide skin comfort and a soothing effect for sensitive skin. Assess the dermatological and ophthalmological tolerance and efficacy in improving skin sensitivity of face cream and balm under normal conditions of use by a population known to be particularly prone to this problem. In a monocentric non-randomized open trial, the cream or balm was applied twice daily to the face, neck, and eye contour of 33 stinger subjects with hypersensitive skin (22-63 years old). Assessments included dermatological and ophthalmological physical and functional signs on Day 1 (D1), D8, and D22, and cosmetic acceptability, cutaneous sensitivity according to a stinging test and the sensitive scale, and the soothing efficacy according to a questionnaire on D22. The cream and balm were very well tolerated. Immediately after application, subjects reported a reduction in the skin's hypersensitivity (93.9% of subjects for the cream and 81.8% for the balm), skin redness (90.9% of subjects for the cream and 87.9% for the balm), sensations of tightness (93.9% for the cream and 97.0% for the balm), and discomfort sensations (93.9% for the cream and 87.9% for the balm). After 21 days, the application of the cream and balm decreased the stinging scores by 65% and 41%, respectively, with 94% and 77% of subjects showing an improvement, respectively. The sensitivity scale questionnaire indicated that the cream and balm significantly and profoundly decreased all negative signs, for example, irritability, stinging, general discomfort, redness, and dryness on D22 compared to D1. On D22, all 15 parameters recorded were improved by 89%-100% by the cream and by 74%-100% by the balm. The majority (90.9% and 96.8% of subjects using the cream and balm, respectively) of the subjects noticed positive changes in their skin condition after using the product for 21 days. The cream and balm were very well-tolerated. This study demonstrated that both products controlled and markedly reduced skin hypersensitivity in Asian subjects, with an immediate and lasting skin soothing and repairing effect over 21 days.

Efficacy of the continuous use of a lotion with carbon dioxide on male subjects with mild acne.

Acne vulgaris is caused by dyslipidemia, dyskeratosis and/or abnormal bacterial growth. The obstruction of skin pores due to hyperkeratosis of the infundibulum contributes to the formation of comedones. Thus, normalizing keratinization of epidermal cells in skin pores might be useful to improve acne. Recently, it has been found that the transcutaneous application of carbon dioxide (CO2 ) regulates imbalances of the desquamatory process. In this study, we evaluated the efficacy of a skin lotion containing CO2 on mild acne. Twenty-four healthy Japanese males (20-29 years old) with mild acne attended this evaluation. The subjects were divided into 2 groups, one group used a skin lotion containing CO2 and the other group used a skin lotion without CO2 . Following facial washing, each subject topically applied the skin lotion with or without CO2 twice a day for 4 weeks. Prior to the start of the evaluation (week 0) and following 2 and 4 weeks of treatment, acne symptoms were assessed by a dermatologist and by instrumental measurements. Topical application of the skin lotion with CO2 for 4 weeks significantly improved acne symptoms, which was recognized by the subjects. However, treatment with the skin lotion without CO2 did not improve acne symptoms. This improvement of acne symptoms by CO2 was not accompanied by changes in sebum levels, skin surface pH, skin capacitance, or porphyrin levels. The transcutaneous application of a lotion with CO2 improves acne symptoms by normalizing keratinization without affecting skin surface conditions.

Directions of hyaluronic acid application in cosmetology.

Hyaluronic acid is a naturally occurring substance in the human body. It is a component of the intercellular matrix of the dermis and is often used as a raw material in cosmetology. This substance was isolated for the first time in the first half of the twentieth century, while cosmetology treatments and aesthetic medicine have been developing rapidly and gaining popularity. The same applies to companies producing cosmetic care products which contain hyaluronic acid. This is related to the growing desire of the society to improve the quality of the skin and maintain its vitality and firmness. The study investigates different directions and possibilities of using hyaluronic acid in cosmetology. Moreover, the paper describes possible side effects observed after hyaluronic acid injections. The study was based on an anonymous questionnaire conducted between October 10, 2021, and February 21, 2022. 513 responses were collected. The awareness and level of knowledge in this field of cosmetology among potential beauty salon clients are on the rise. Hyaluronic acid is used in injections, as well as in care cosmetics, oral and vaginal preparations. Various areas of the face are injected, most often the lips. Face creams are among the most frequently purchased skincare products. The use of hyaluronic acid in cosmetology is multidirectional. It is mainly focused on skincare and specific anti-aging activities. Treatments of this type help preserve the skin's vitality, which translates into an improved quality of life due to the satisfaction of the need for attractiveness.

Lavender (Lavandula angustifolia Mill.) industrial by-products as a source of polysaccharides

Apart from the main aroma products, the lavender essential oil industry generates huge quantities of undervalorized biomass, which was discarded nearby to the distilleries or used as a fertilizer. Therefore, the current study was performed to explore the hypothesis that the lavender waste biomass could be additionally utilized as a source of polysaccharides . An industrial residue from supercritical CO 2 -extraction (CO2-L) and steam-distilled lavender (SD-L) were used as source material after preparing the alcohol-insoluble material. Acid-soluble polysaccharides (ASPs) were obtained from CO2-L (6.97 ± 0.14%) and SD-L (5.95 ± 0.23%). The monosaccharide composition revealed that polysaccharides were composed mainly of galacturonic acid 672.44 ± 4.89 µg mg −1 (CO2-L) and 619.17 ± 5.23 µg mg −1 (SD-L). The ASPs were characterized by a medium degree of methyl-esterification (50%) and a low degree of acetylation (<3%). The pectin nature of lavender ASPs was confirmed by infrared and NMR spectroscopy experiments. ASPs’ gelling behavior was investigated by examination of high sucrose (1.25% polysaccharide and 60% sugar (w/w)) and Ca 2+ (1.25% polysaccharide (w/w) and 6 mmol/L Ca 2+ ) gel systems and compared with the gelation of two commercial citrus pectins. Both CO2-L and SD-L ASP were able to produce Ca 2+ gels, while in the presence of sucrose only the CO2-L polysaccharide yielded gel. ASPs were included in the hand cream formulation. It was found that both polysaccharides increased the apparent viscosity compared to the control hand cream. This might lead to the conclusion that lavender wastes could be regarded as a natural source of polysaccharides having valuable properties to enable incorporation into cosmetic products. • Lavender by-products from CO 2 extraction (CO2-L) and distillation (SD-L) were studied. • CO2-L and SD-L yielded 6.97 ± 0.14% and 5.95 ± 0.23% polysaccharides, respectively. • Monosaccharide composition and NMR studies suggested pectic type structure. • CO2-L and SD-L polysaccharides yielded relatively strong gels in presence of Ca 2+ . • CO2-L and SD-L polysaccharides increased the apparent viscosity of hand creams.

The potential benefit of rooibos (Aspalathus linearis) in pulmonary arterial hypertension: A short review

Rooibos is a uniquely South African plant cultivated to produce rooibos herbal tea or extract and often incorporated into iced herbal tea, soap, skin lotion, facewash, and shampoo. Rooibos provides health benefits against multiple diseases including cardiac pathologies, skin disorders, obesity, and diabetes via its anti-inflammatory, antioxidant, anti-tumour, and anti-apoptotic properties. The pathophysiology of pulmonary arterial hypertension (PAH) includes increased lung inflammation and oxidative stress, and tumour-like growth (i.e., the increased proliferation of pulmonary arterial smooth muscle cells and apoptosis of pulmonary artery endothelial cells). In this review, we discuss literature supporting rooibos as a potential novel therapeutic agent to protect against PAH. We suggest that rooibos may reduce lung inflammation and oxidative stress and limit pulmonary arterial smooth muscle cell proliferation and endothelial cell apoptosis, thereby inhibiting PAH progression. • Rooibos is a unique South African plant, cultivated to produce rooibos tea or extract that is high in polyphenols. • Rooibos provides health benefits against cardiac pathologies, skin disorders, obesity, and diabetes. • The anti-inflammatory, antioxidant, anti-tumour, and anti-apoptotic actions of rooibos makes it a candidate therapeutic agent against pulmonary arterial hypertension (PAH). • Rooibos may reduce lung inflammation, oxidative stress, limit pulmonary arterial smooth muscle cell proliferation and endothelial cell apoptosis, thereby inhibiting PAH progression. • Evidence discussed in this paper supports the role of rooibos as a possible novel therapeutic agent in the context of PAH.

Quality and safety investigation of commonly used topical cosmetic preparations

Cosmetic and personal care products are considered an essential part of our daily care routine; hence, these products must be stable and safe for human use. This study aimed to assess the quality and safety of the most common cosmetic preparations. To select the products to be tested, a cross-sectional survey was distributed featuring the most used types and brands of products. Based on 447 responses from both males and females with different ages and education levels, 21 products from different brands were selected and tested in terms of microbial load, heavy metal content, and organoleptic properties. Microbial contamination was investigated using the aerobic plate count method. Lead (Pb), aluminum (Al), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), zinc (Zn), iron (Fe), and arsenic (As) impurities were analyzed using an inductively coupled plasma mass spectrometer. The products included sunblock, lip balm, hand cream, hair cream, shampoo, cleanser, baby oil, baby powder, bar soap, hair dye, makeup, deodorant, hair serum, shaving gel, and toothpaste. Microbial contamination was found in 14 of the products, ranging between 1467.5 and 299.5 cfu/ml. The most commonly isolated microorganisms were Staphylococcus aureus and Bacillus species. Most of the tested products showed metal impurities, with toothpaste having the highest concentrations of Pb, Cr, As, Cu and Ni. The samples did not show lumps or discoloration, did not have characteristic odors, and had pH values ranging from 6.90 to 8.10. The continuous usage of such products could lead to serious negative consequences. As a result, ensuring the quality of cosmetic products is critical. Regulatory authorities are required to enforce strict legislation on cosmetic manufacturing to assess and ensure the quality and safety of the products before they reach consumers.

Flow Injection Sensing Strategy for Determining Cationic Surfactants in Commodity and Water Samples

The formation of stable binary water-soluble sub-micellar aggregates of cetyltrimethylammonium bromide-copper-pyrocatechol violet complex (CTAB-Cu-PCV) diminishes the stability and absorbance of the Cu-PCV complex. A new flow injection spectrophotometric sensing strategy used for the determination of CTAB in commodity personal care antiseptics and water samples has been established relying on the above-mentioned concept. Based on the reduction of the absorption of the Cu-PCV solution by the injection of CTAB solution at pH 6.0 and 430 nm, a linear absorbance decrease was observed over the CTAB concentration range of 2.0 to 100.0 µg mL−1 (r = 0.987). The analysis method showed limits of detection (3.3 ơ) and quantification (10 ơ) of 0.08 and 0.27 µg mL−1, respectively. The precision (RSD) for five replicate determinations was 7.9 and 3.7% at 10 and 50 µg mL−1, respectively. The developed method was applied successfully to the determination of CTAB in personal care products, namely skin lotion and vaginal wash, in addition to water samples. The corresponding RSD (n = 5) values were ≤8.2%.

Use of Hand Creams during the Period of Frequent Disinfection in COVID-19 Pandemic-Preference Survey and Evaluation of Mercury Contamination.

The skin is one of the ways the human body is exposed to toxic elements, including mercury (Hg). Hand creams are cosmetics that should be of high quality due to the fact that they can be used on irritated skin, which can facilitate the absorption of many ingredients. The study consisted of two stages: a consumer questionnaire was conducted regarding the preferences of the respondents, and then the Hg content in hand creams was determined. The survey covered 184 people with an age of 26.9 ± 7.8 years. Based on their preferences, 140 hand creams were selected for the study. The Hg content in the creams was determined by atomic absorption spectrometry with the amalgamation technique. The median content of this toxic element was 4.067 µg/kg. No influence of the country of origin, price, package size, main ingredients, and direction of action on the Hg content was shown. Noncarcinogenic risk assessment using the hazard quotient (HQ) indicated that the tested creams are safe. However, it should be emphasized that Hg has been shown in over 99% of the samples, which indicates that the content of this element in hand creams should be monitored.

Analysis of the Beautiful Concept in Marina Ads (Study of Semiotic Analysis on Marina UV White Hand &amp; Body Lotion Advertisement)

Advertising is information content that promotes a product or service to be known, demanded, and purchased by the public. However, without realizing it, advertisements are able to persuade and create a point of view for the audience. People are led to create a point of view based on what advertisers put on advertisements. The ability of advertising in creating a construction of reality or point of view and persuading individuals has brought about various changes in lifestyle and culture. Various products and services offered in television advertisements are in the form of primary needs and secondary needs. Examples of secondary needs that are currently considered very important for women are skincare or skin care from the body to the face. One advertisement for body care products is Marina UV White Hand &amp; Body Lotion. This study aims to determine the meaning of the beautiful white concept in the Marina UV White Hand &amp; Body Lotion advertisement. By using Roland Barthes' qualitative semiotic method (denotation, connotation and myth), it can be concluded that Marina's advertisement is able to break the myth that has been circulating in society regarding beauty and women.&#x0D; .

Enjoyment or autonomy? The interactive effect of brand ritual and brand personality on consumer purchase

AbstractThe use of brand rituals is a pervasive tactic in business, but the marketing effectiveness of this practice largely remains unknown. In the present research, we postulate the contingent nature of brand rituals on consumer purchase. Based on the two countervailing processes—the enhancement of perceived enjoyment and the reduction of perceived autonomy, we suggest that the effectiveness of brand rituals is determined by the interaction between the degree of brand ritual (simple vs. sophisticated) and the brand personality (excitement vs. sincerity). By means of field and laboratory experiments in various product categories (i.e., fruit tea, juice, stationery, and hand cream), we show that for a sincere brand, a sophisticated brand ritual elicits higher consumer purchase than a simple brand ritual only via the process of enhanced enjoyment because its sincerity personality weakens the salience of the process of reduced autonomy. In contrast, for an exciting brand, a sophisticated brand ritual elicits lower consumer purchase than a simple brand ritual via the process of enhanced enjoyment but reduced autonomy (the autonomy route dominates the enjoyment route) because its exciting personality intensifies the salience of the process of reduced autonomy. In simple words, a sophisticated brand ritual benefits a sincere brand, but a simple one benefits an exciting brand. Our findings extend the research on ritual and brand ritual and offer implications for marketing practice regarding how to design a brand ritual more effectively.

Valorisation of Kiwifruit Residues and their Application in an Anti-ageing Facial Cream

Portugal has a significant production of kiwifruit, from which around 73.8 tons of leaves and branches are generated every year. The composition of these residues shows interesting properties that could be incorporated into a value-added product. In order to create a new product, the steps proposed by the Chemical Product Design procedure were followed: identifying the needs, brainstorming ideas, selecting the best idea, proposing a manufacturing process. The chosen idea was an anti-ageing facial cream since the kiwifruit leaves and branches present interesting properties such as antioxidant, anti-inflammatory and anti-pigmentation effects. In order to obtain this product, a manufacturing plan was designed, and an economic analysis was performed. The proposed circular economy business was found to be profitable and environmentally friendly. This work also includes further innovative steps of the facial cream, such as pigmentation.

Transfer pattern of hormesis into personal care product mixtures from typical hormesis-inducing compounds

Some personal care products (PCPs) and their chemical components showed a hormetic effect in the freshwater photobacterium Vibrio qinghaiensis sp. -Q67 (Q67) after long-term exposure. However, how hormesis transfers between chemical components and PCP mixture, and which chemical component plays a major role remain unknown. To this end, according to the seven compounds detected in one skin lotion (SK5) and their concentration ratios, many mixture rays were constructed to simulate the SK5. Of these seven compounds, three presented monotonic concentration-response curves (CRC) to Q67 at 0.25 and 12 h (called a S-shaped compound). The other four compounds showed hormetic CRCs after 12 h and monotonic CRCs at 0.25 h (called a J-shaped compound). Based on their mixture ratios, we designed one ternary mixture ray of all S-shaped compounds, one quaternary mixture ray of all J-shaped compounds, and four quaternary mixture rays of one J-shaped and three S-shaped compounds. It was shown that SK5 could be approximately simulated by the mixture ray of the seven compounds detected in SK5 and only the mixture rays containing at least one hormesis-inducing compound produced hormesis to Q67 at 12 h. Based on the concentration ratios of various compounds and comparison of four hormetic characteristic parameters to those of various mixture rays, it was found that the compound betaine (BET) is a key compound affecting the hormesis of mixtures. Additionally, we studied the hormesis mechanism of BET on Q67 via quorum sensing (QS). This preliminarily indicated that the autoinducer-2 triggered the QS pathway. This study elucidated the transfer pattern of hormesis into mixtures, which would be an efficient method to identifying the potential components that affect hormesis transfer in mixtures. We expect that this study will provide new insights into hormesis and its mixtures.

Lignin as a bioactive polymer and heavy metal absorber- an overview

As a pulping and bio-refinery by-product with phenolic chemical structure, lignin indicated high potential as natural antioxidant activity, UV blocker, antibacterial and toxic material absorbent properties. Presence of phenolic hydroxyl groups in lignin structure plays the main role of its antioxidant activity. However, lignin antioxidant power can change depending on its other structural features and functional groups like ortho-methoxy groups, –OCH3 groups, the α-CH2 groups, the aliphatic carbonyl groups, and the size of π-conjugated systems. Lignin in mixture with synthetic polymers, improved their thermal stability. Lignin has high UV light absorbing potential in broad-spectrum (UVA, UVB). Adding 1–5% of lignin into hand cream indicated excellent range of sun protection factor (SPF) with more than 95% UV light absorption. Lignin also indicated strong UV light protection when applied in different transparent film and protect paint, oil, and varnish from UV degradation. Lignosulfonate and other modified lignin including chemically modification, nano-particles and lignin hydrogel indicated high potential as heavy metal absorber.

Measurement of Stress Relief during Scented Cosmetic Product Application Using a Mood Questionnaire, Stress Hormone Levels and Brain Activation

Nowadays, consumers’ well-being plays a decisive role in the purchase of cosmetic products. Although factors influencing consumers’ well-being are very subjective, companies strive to develop their products in such a way that a positive effect is likely. Therefore, methods are required to objectively explore and scientifically prove the product’s performance on humans. In this placebo-controlled study, a method was developed to evaluate relaxation or stress relief associated with one olfactory ingredient of a cosmetic product (face cream). Our experimental protocol included product testing in 25 healthy females, while an emotion questionnaire, analysis of saliva samples regarding the concentration of the hormones cortisol and α-amylase and mobile EEG measurement for quantification of the alpha brain waves before and after stress induction were conducted. It was shown that with this experimental design, the sample with the ingredient produced significant stress relief, as evidenced by significantly less negative emotion, significantly lowered cortisol levels and showed a trend towards a significant increase in alpha activity compared to placebo application. Our data provide evidence that this method is suitable for analyzing the differences between the two samples. In the future, this method can be utilized in the current or a further optimized form to evaluate the psychophysiological effects of cosmetic products on humans.

33565 Clinically proven antiaging effects of a new skincare line and retinol tolerance building guidance for Asian consumers

Skin preaging is a concern raised by young consumers. A new skincare line including facial essence, eye cream, and face cream, which combines active ingredients of retinol, dipeptide and fullerene, was developed to target skin concerns of wrinkles and sagging. The objective of this study was to assess the tolerance and efficacy of the products and develop tolerance-building guidance for Asian consumers. A clinical study in 120 Chinese females aged 43-64 with signs of facial wrinkles and sagging was randomized into 3 subgroups.

33565 Clinically proven anti-aging effects of a new skincare line and retinol tolerance building guidance for Asian consumers

Skin preaging is a concern raised by young consumers. A new skincare line including facial essence, eye cream, and face cream, which combines active ingredients of retinol, dipeptide and fullerene, was developed to target skin concerns of wrinkles and sagging. The objective of this study was to assess the tolerance and efficacy of the products and develop tolerance-building guidance for Asian consumers. A clinical study in 120 Chinese females aged 43-64 with signs of facial wrinkles and sagging was randomized into 3 subgroups. G1 used essence once daily, G2 used regimen under tolerance building guidance, and G3 used placebo cream. All subjects were provided with auxiliary moisturizers and sunscreens. Noninvasive instruments, imaging, clinical grading, and self-evaluation were performed at 0, 4, 8, 14, and 20 weeks. Essence and regimen both provided statistically significant improvement on wrinkles as early as 4 weeks, and on all efficacy endpoints, including hydration, smoothness, radiance, elasticity, 7 types of wrinkles, 3 types of sagging throughout the study. AVEA-HE showed the essence and regimen could significantly lift the jawline contour by 2.53 mm and 2.88 mm after 8 weeks, respectively. Retinol-related irritation including redness and dryness occurred during the first month. After following the usage instructions, 94% subjects were tolerant to the irritation. The clinical results showed that the new essence and regimen are efficacious for antiwrinkle and contour lifting. Combined with the tolerance building guidance, consumers would be able to minimize irritation, achieve better results and user experience.