Abstract Electrocardiograms, Electromyogram, and Electroencephalogram, are very few extensions and low frequencies electronic detection system. An important part of their biomedical detection electronic system is the biopatensive props-device. In this article, analog front-end in a current mode has been proposed to bioptational signal acquisitions. It includes programmable profit-current (PGC) mode amplifier (MA) and 2nd current mode low-pass filter (CM-LPF). Amplifier operated and low-pass filter externally used ELIN circuits. EIN blocks were executed by the use of log-domain circuits. In the proposed circuit, a combination of pull up and pull down transistors which acts as an inverter is used for biasing purpose. The biasing is done in such a way that the transistors switch their region of operation between cutoff region and saturation region in order to perform switching action. The proposed current mode analog front-end consumes less material to implement circuit design.