Angioleiomyoma Research Articles

口腔領域に発生した血管筋腫の３症例と免疫組織学的検討

3 cases of vascular leiomyoma arising in the oral area were examined. The first case was a 72-year-old male showing slight swelling of the median palate. The second case was a 60-year-old male showing a red bean sized elastic hard mass in the right lower lip. The third case was a 57-year-old male with an appearance in the left nose vestibule.Histologically, all cases revealed that polygonal shaped smooth muscle like tumor cells proliferate perivascular area and formed small nodules with entangled muscle fibers. An immunohistochemical analysis showed that strong positive reaction for the VIIIth factor-related antigen in cord-like arranged tumor cells and in angioendothelial cells. The actin was positive for outer layer cells of the vesseles.Positive reaction for desmine was observed in fibroblastoid cells. The vimentin was positive for angioendothelial cells and most of the tumor cells.

鼻腔原発平滑筋腫症例

We treated a 45-year-old woman who had complained of left nasal obstruction for three years. A spherical tumor was found in the nasopharyngeal space and was removed surgically under general anesthesia in our hospital. The 30×24×15 mm tumor arose from the end of the left middle turbinate. Histopathological examination revealed a vascular leiomyoma. It is relatively uncommon for leiomyomas to develop in the nasal and paranasal cavities. Only 36 such cases have been reported in Japan; ours is the 37th case.

Leiomyoma of a Digital Artery

Benign, soft-tissue masses of the hand are common. A vascular leiomyoma is an unusual tumor of smooth-muscle origin. In a 62-year-old man, the tumor arose from within a digital artery. Persistent symptoms prompted an excisional biopsy, requiring resection of a portion of the artery. Adequate collateral circulation preempted the need for a vascular graft. Vascular repair or grafting may be necessary if collateral circulation is not adequate.

Cutaneous Inflammatory Pseudotumor

This report describes four cases of a previously undocumented circumscribed idiopathic inflammatory fibrosclerotic lesion of the skin. The lesions occurred in two black women and two white men; they had been apparent from months to a year. The nodules were solitary; two were located on the arm, one on the calf, and one on the posterior neck. The clinical diagnoses included nodules, keratinous cyst, pilar tumor, pilomatricoma, vascular leiomyoma, dermatofibroma, and metastatic carcinoma. The lesions were grossly white, homogeneous, and circumscribed; one was located in the superficial subcutis and three in the reticular dermis. Histologically, they were sharply circumscribed and surrounded by a dense peripheral rim of lymphocytes and plasma cells. Peripheral germinal centers were noted in two cases. All cases had variable amounts of fibrosis centrally, giving them the low-power appearance of lymph nodes; however, no subcapsular or medullary sinuses were found. In the center of the lesions, the mononuclear infiltrate was accompanied by eosinophils and neutrophils. Virtually imperceptible vasculature was noted in portions of three lesions; in the fourth lesion, high endothelial venules were seen in the lymphoid portions, and "targetoid" perivascular sclerosis was seen in the central portions. There appears to be a transition from the early, mostly inflammatory, lesions to the sclerotic ones. The process seems to be reactive in nature. No obvious local or systemic etiology was found in our series, and follow-up of 2 to 5 years has been noncontributory. These mixed-cell proliferations resemble the extracutaneous masses that have been described in numerous viscera--particularly the lung--as "inflammatory pseudotumors" or "plasma cell granulomas." In our opinion, these lesions also bore a superficial resemblance to cutaneous lymphoid hyperplasia secondary to insect bites. Other differential diagnostic considerations include dermatofibroma, nodular fasciitis, Kimura's disease, epithelioid (histiocytoid) hemangioma, and reactive lymph nodes.

Intermediate and fine filaments of vascular leiomyomas (angiomyoma), leiomyoma and leiomyosarcomas of large veins.

The expression of fine and intermediate filaments in 10 cases of leiomyosarcoma originating from a large vein, 9 cases of vascular leiomyoma (angiomyoma) and one case of a leiomyoma originating from the wall of the saphena magna vein was studied immunohistochemically by using 6 different anti-desmin antibodies, one anti-vimentin antibody and 2 antibodies to muscle-specific isoforms of actin. All the benign tumors and all the leiomyosarcomas of a large vein as well as the vein of origin were positively stained for desmin. The staining results obtained using the different anti-desmin antibodies varied considerably, however, and formaldehyde-fixed tissues were apparently inappropriate for some of them. No single anti-desmin antibody produced a positivity in all cases, and the extent and distribution of the positivity varied by being irregular and patchy in the leiomyosarcomas and in the muscle walls of the veins, while the benign tumors generally revealed a more uniform and strong positivity. Antibodies to muscle-specific and smooth muscle-specific actin produced a positive staining in all the benign tumors, as well as all the leiomyosarcomas and the veins from which they originated. A strong and uniform positivity was observed in the benign tumors and muscle walls of the veins, while the positivity in the leiomyosarcomas was more irregular, as it was for desmin. Vimentin was constantly expressed in the benign tumors and in the veins of origin, but only in 5/10 of the leiomyosarcomas. It is concluded from this study that the immunohistochemical demonstration of desmin, utilizing a monoclonal antibody appropriate to the type of fixation used, and muscle specific isoforms of actin, provide strong support to the light-microscopic diagnosis of leiomyosarcoma of venous origin.

Angiomyoma of the upper lip: Report of a case with electron microscopic and immunohistochemical observation

Immunohistochemical and electron microscopic observations of a vascular leiomyoma of the upper lip are presented. Tumour cells were positive for desmin, vimentin and neuron specific enolase but not for S-100 protein. Factor VIII was detected in the endothelium of blood vessels. Ultramicroscopically, the spindle-shaped tumour cells had elongated nuclei and cytoplasm containing abundant myofilaments and pinocytotic vesicles. Emphasis is placed on the fact that an immunohistochemical approach using appropriate antibodies can be used in identifying this tumour.

上顎前歯部に発生した血管筋腫の１例

Vascular leiomyoma is a benign tumor first reported by Stout in 1939. It is frequently observed in the skin, especially in the lower extremities, but seldom in the oral cavity.The purpose of this paper is to report a case of vascular leiomyoma arose from the maxillary mucolabial fold in a 38-year-old female. Review of the literature revealed 25 cases in Japan and 68 in other countries reported to date.The patients ranged from infancy to 69 years old and sex ratio was 5:2, with a inclination to males. The clinical appearance of vascular leiomyoma was small, painless, and sessile mass, although painful lesion in the lower extremities. Etiology was presumed to be infection, traumatic force or estrogen influences, etc.Histopathological examination indicated that this tumor was composed of a tortous mass of blood vesseles between interwinding bundles of smooth muscle.

Nonpainful, smooth-surfaced, bluish nodule on the upper lip

A case of a vascular leiomyoma of the upper lip has been presented. A review of the literature was completed, and the findings reported. Leiomyomas are rare intraoral neoplasms. When affecting the mouth, they are most likely to occur on the tongue, palate, buccal tissues, and lips. Conservative local excision is the recommended treatment.

耳下腺血管平滑筋腫の一例

A case of vascular leiomyoma of the parotid gland is reported. The patient was a 37-year-old male with a left parotid tumor. The tumor was removed under general anesthesia. Histological examination revealed vascular leiomyoma. No recurrence has been noticed for 9 months after operation. Leiomyoma is a benign tumor which commonly occurs in the smooth muscle of the uterus, digestive organs or skin. This is the first case of leiomyoma of the parotid gland in Japan.

Chronic pain: illusion or pathology? A case report of a vascular leiomyoma in the leg

Patients with chronic pain constitute a major problem for the surgeon as the cause of their pain is often difficult to diagnose and is only rarely a well circumscribed lesion which is amenable to surgical or other treatment. We report a case of chronic pain due to a vascular leiomyoma beneath the deep fascia of the leg. Angioleiomyomas are rare tumours that are usually found in the subcutaneous tissue.

Chronic pain: illusion or pathology? A case report of a vascular leiomyoma in the leg

Chronic pain: illusion or pathology? A case report of a vascular leiomyoma in the leg

Vascular leiomyoma in the hand

Two patients with vascular leiomyomas of the hand are reported. These lesions are probably not as rare as the literature suggests. There are three pathologic types--solid, cavernous, and venous type tumors. All are composed of smooth muscle bundles surrounding vascular channels.

Ａｎｇｉｏｌｅｉｏｍｙｏｍａにおけるとう痛と神経分布との関係

Angioleiomyomaは有痛性皮下結節として知られ, 自発痛, 圧痛, 放散痛のなんらかの疼痛を伴うのが通例とされているが, 一部では必ずしも疼痛を伴わないものもある。今日まで神経細胞, 神経線維, 髄鞘に対するあらゆる特殊染色を行つても, 腫瘍内にその存在を明確にすることは困難であつた。われわれは過去10年間に経験した12症例にS100蛋白の特殊染色を施行して疼痛と神経分布との関係を追求した。

鼻腔に発生した血管平滑筋腫の一症例

A case of vascular leiomyoma of the nasal cavity is reported.The patient was a 59-year-old male who complained of intermittent nasal bleeding in his thirties. A spherical tumor was seen on the right inferior turbinate. He was treated surgically via the transmaxillary aproach under general anesthesia. The histopathological findings revealed vascular leiomyoma.

Mandibular vascular leiomyoma

A 54-year-old man had a symptomless swelling on the buccal aspect of the right mandibular molar area, this was associated with a multilocular radiolucency. Histologic and ultrastructural examination of the lesion revealed a vascular leiomyoma. This is only the fourth intrabony leiomyoma of the jaws to be reported.

Vascular leiomyoma of the oral cavity

Leiomyomas may occur in the humam body wherever smooth muscle is present. The uterus is the most common site; 20% of reported cases occur in uteri of women over the age of 30 years. 1 Other sites are the wall of the alimentary tract, the skin, and the subcutaneous tissue. 2 The earliest case of leiomyoma of the oral cavity was reported by Blan 3 in 1884 in a 33-year-old man. The leiomyoma is considered a rare tumor of the oral cavity; our review of the literature has disclosed only 68 reported cases.

Vascular Leiomyoma of the Auricle

Vascular leiomyoma arises from the muscle coat of blood vessels and is mainly seen as a solitary nodule on an extremity, usually the lower part of the leg, in middle-aged and elderly persons.¹We report an unusual case of an 18-year-old man who had such a tumor on his right auricle. <h3>Report of a Case</h3> A 18-year-old man was referred to us for evaluation of a tumor on his right auricle. A pea-sized, skin-colored mass, first noted six years previously, had slowly increased in size and become purple. There was no history of antecedent trauma. Examination of the patient disclosed a soft, broad-based, nontender, well-circumscribed, mobile, nonpulsatile, purple mass on the right auricle (Fig 1). It measured 1.3 × 1.2 cm. Routine laboratory tests, including urinalysis, CBC count, blood chemistries, and chest roentgenogram were all within normal limits. An excisional biopsy was performed, followed by a full-thickness graft of

Vascular leiomyoma of the auricle

Vascular leiomyoma arises from the muscle coat of blood vessels and is mainly seen as a solitary nodule on an extremity, usually the lower part of the leg, in middle-aged and elderly persons.¹We report an unusual case of an 18-year-old man who had such a tumor on his right auricle. <h3>Report of a Case</h3> A 18-year-old man was referred to us for evaluation of a tumor on his right auricle. A pea-sized, skin-colored mass, first noted six years previously, had slowly increased in size and become purple. There was no history of antecedent trauma. Examination of the patient disclosed a soft, broad-based, nontender, well-circumscribed, mobile, nonpulsatile, purple mass on the right auricle (Fig 1). It measured 1.3 × 1.2 cm. Routine laboratory tests, including urinalysis, CBC count, blood chemistries, and chest roentgenogram were all within normal limits. An excisional biopsy was performed, followed by a full-thickness graft of

Leiomyoma of the Scrotum

Leiomyoma is a benign tumor derived from smooth muscle. The following three types of superficial leiomyoma are recognized: (1) single or multiple lesions of leiomyoma derived from the arrectores pilorum muscles, (2) leiomyoma derived from the muscularis of blood vessels (vascular leiomyoma), and (3) leiomyoma (usually solitary) derived from the smooth muscle of the nipple or scrotum.1 Scrotal leiomyomas are rare. In 1937, Stout1 found only five cases recorded in the world literature. In 1964, Grace2 reported two cases from the literature and added an eighth case report. Siegal and Gaffey3 reported ten cases between 1905 and 1975 from the records of the Mayo Clinic, Rochester, Minn. Another case was recorded in 1977 by Iloreta and associates,4 and an additional case of leiomyoma of the scrotum is reported herein. Report of a Case A 49-year-old man was admitted to the urological department because of a left scrotal mass that had

Oral leiomyoma. Report of six cases and a review of the literature.

Benign tumors of smooth muscle origin are rare in the oral cavity. This paper reviews 67 cases from the literature and six previously unpublished cases of oral leiomyoma. Tongue, hard palate and buccal mucosa are the most common sites of this lesion and the vascular leiomyoma or angiomyoma is the predominant histologic type.