Sensory Channels Research Articles

Crossmodal interference on counting performance: Evidence for shared attentional resources.

During the act of counting, our perceptual system may rely on information coming from different sensory channels. However, when the information coming from different sources is discordant, such as in the case of a de-synchronization between visual stimuli to be counted and irrelevant auditory stimuli, the performance in a sequential counting task might deteriorate. Such deterioration may originate from two different mechanisms, both linked to exogenous attention attracted by auditory stimuli. Indeed, exogenous auditory triggers may infiltrate our internal "counter", interfering with the counting process, resulting in an overcount; alternatively, the exogenous auditory triggers may disrupt the internal "counter" by deviating participants' attention from the visual stimuli, resulting in an undercount. We tested these hypotheses by asking participants to count visual discs sequentially appearing on the screen while listening to task-irrelevant sounds, in systematically varied conditions: visual stimuli could be synchronized or de-synchronized with sounds; they could feature regular or irregular pacing; and their speed presentation could be fast (approx. 3/sec), moderate (approx. 2/sec), or slow (approx. 1.5/sec). Our results support the second hypothesis since participants tend to undercount visual stimuli in all harder conditions (de-synchronized, irregular, fast sequences). We discuss these results in detail, adding novel elements to the study of crossmodal interference.

Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons.

Sensory neurons enable an organism to perceive external stimuli, which is essential for survival. The sensory capacity of a neuron depends on the elaboration of its dendritic arbor and the localization of sensory ion channels to the dendritic membrane. However, it is not well understood when and how ion channels localize to growing sensory dendrites and whether their delivery is coordinated with growth of the dendritic arbor. We investigated the localization of the DEG/ENaC/ASIC ion channel Pickpocket (Ppk) in the peripheral sensory neurons of developing fruit flies. We used CRISPR-Cas9 genome engineering approaches to tag endogenous Ppk1 and visualize it live, including monitoring Ppk1 membrane localization via a novel secreted split-GFP approach. Fluorescently tagged endogenous Ppk1 localizes to dendrites, as previously reported, and, unexpectedly, to axons and axon terminals. In dendrites, Ppk1 is present throughout actively growing dendrite branches and is stably integrated into the neuronal cell membrane during the expansive growth of the arbor. Although Ppk channels are dispensable for dendrite growth, we found that an over-active channel mutant severely reduces dendrite growth, likely by acting at an internal membrane and not the dendritic membrane. Our data reveal that the molecular motor dynein and recycling endosome GTPase Rab11 are needed for the proper trafficking of Ppk1 to dendrites. Based on our data, we propose that Ppk channel transport is coordinated with dendrite morphogenesis, which ensures proper ion channel density and distribution in sensory dendrites.

Response to visual and mechano-acoustic predator cues is robust to ocean warming and acidification and is highly variable in European sea bass

Predator-prey interactions and, especially, the success of anti-predator responses are modulated by the sensory channels of vision, olfaction, audition and mechanosensation. If climate change alters fish sensory ability to avoid predation, community dynamics can be affected. We investigated whether mid-duration exposure to warming and/or acidification alters behavioural response to visual or mechano-acoustic predator cues in juvenile Dicentrarchus labrax. We measured kinematic variables before and after a visual or a mechano-acoustic challenge which mimicked an overflying bird shadow or a bird swoop attack, respectively. Due to large interindividual variability in responses before cue presentation, fish were categorized as slow and fast to account for baseline individual variability. Treatment did not impact kinematic variables as both slow and fast fish of every treatment elicited precautionary and escape responses. Interestingly, even slow fish swam as fast as fast fish after the cue, suggesting that regardless of initial category, fish managed to escape facing a danger. Anti-predator response varied according to the level of threat to survival with greater responses elicited after the swoop attack. Although wild juvenile sea bass aggregate in schools, school dynamics rely on single leaders which highlights the importance of the variability in individual behaviours. We demonstrated that anti-predator response in juvenile D. labrax is robust to mid-duration exposure to independent and combined effects of warming and acidification. If robustness is confirmed over long-duration, it could provide D. labrax with an evolutionary advantage in the future ocean, where cue transmission through changing environments can further modulate cue perception and predator-prey interactions.

Measuring users’ emotional responses in multisensory virtual reality: a systematic literature review

Virtual reality and emotions have become inseparable concepts over the past few years, supported by the increasing number of studies relating them. However, these studies' methodologies are often poorly justified or dependent on the authors' subjective definition of emotion and its classification. Moreover, frequently, these studies only consider two stimuli, specifically audiovisual, despite being known the relevance of including a greater variety of sensory channels to improve the relationship between the individual and the virtual environment. So, to address these gaps, and considering the importance of multisensory stimulation, this paper aims to review the methods and instruments found in the literature regarding the analysis of the users' emotions in virtual reality. Also, we provide an overview of the main limitations of such studies. Little information can be found in the literature regarding the connection between the input stimulus and the users’ emotional responses. This corroborates the difficulty in creating and evaluating immersive virtual experiences when stimulating more than two human senses, typically audiovisual. Nevertheless, we address some clues on the impact of visual, auditory, haptic, smell, and taste elements to trigger specific emotions. Also, we address the association between the research area and the method used. Finally, the main gaps and challenges are discussed. We expect that the combination of these results acts as guidelines for designing richer multisensory virtual experiences. Moreover, we intend to contribute to future research on emotions-based immersive virtual reality by providing a review of the most suitable methodologies and instruments for specific contexts.

ЗНАЧЕННЯ ФУНКЦІЇ РІВНОВАГИ ДЛЯ ПСИХОМОВЛЕННЄВОГО РОЗВИТКУ ДІТЕЙ З ОСОБЛИВИМИ ОСВІТНІМИ ПОТРЕБАМИ

The article examines the significance of the balance function and the organs responsible for it in the general psychophysical development of children from the perspective of neurophysiology, neuropsychology, and neuropedagogy. The basis of the development and improvement of this function lies in the child's relationship with the two dual components of his existence: the gravitational force of attraction and the earth's support. On the basis of this interaction, the necessary supporting and straightening reactions are gradually formed, which in the future need to ensure a stable position of the child's body in an orthograde two-support position. First, the child's static equilibrium is formed (in place, not moving), then it improves to static-dynamic equilibrium (in the city, but moving) and finally, the child masters dynamic equilibrium (in motion). The balance function is based on the postural system of aplomb with its five external and internal channels: vestibular, visual, oculomotor, proprioceptive, gifted, articulatory (lower jaw) and auditory. Synchronization of the activity of these input channels provides appropriate and adequate postural reactions to preserve the child's body in space. The vestibular system is of particular importance, since it is the most widely represented in the formations of the child's brain and interacts with other sensory channels. The authors proposed the following algorithm for using the possibilities of the balance function in the sensorimotor development of children in the context of improving their psycho-speech development: the formation of support-rectifying antigravity reactions and poses; development of static balance in stationary poses; development of stato-dynamic equilibrium; development of dynamic balance, moving with purposeful progress in different directions; the development of vestibulo-motor reactions for the formation of the child's orientation in space (in the «space of his body», minispace, macrospace). Keywords: balance function, children with special educational needs, speech development.

S8-5 INTERACT capacity building framework for sport for all among sports federations

Abstract Purpose International Sports Organisations (ISOs) have increasing interest in investing on sport for all and have been called by policy-makers through different policies (e.g. WHO Global Action Plan for physical activity, UN Sustainable Development Goals) to leverage their health and physical activity potential towards the society. This presentation showcase a training (in-person, informal education workshop) that aims to empower the staff and volunteers of ISOs promote Sport for All and physical activity and act as multipliers to train their national federations and grassroot sport organisations. Project The INTERACT Capacity-Building Framework which was designed by INTERACT Erasmus+ project partners (TAFISA and 8 International Sports Organisation) through different meetings and a co-construction approach, addresses key elements, identified as part of the INTERACT project, to support ISOs and continental/national sport federations in developing their own Sport for All and physical activity initiatives and engage with their members in the field. It provides exchange of knowledge and training to empower ISOs, their staff and volunteers in Sport for All and place physical activity promotion at the core of their activities. This will in turn increase participation in sport and physical activity. By using different sensory channels (e.g. visual, acoustic, tactile), our approach satisfies the participant’s different learning types and primary ways of absorbing and processing information. Composed of three steps (advocacy, diagnostic, training), it alternates theory and practice as well as tension and relaxation, movement and rest. Participant-oriented educational work includes the conscious handling of diversity and diversity of people (e.g. in relation to sex/gender, nationality, ethnicity, religious belief, disability, sexual orientation etc.). A first pilot has been launched among 12 ISOs, and evaluation framework will be created this spring, based on a litterature review. Conclusion The INTERACT Capacity-building programme is developed to become a full-fetched service that is offered in the coming years to any ISO willing to step up its promotion of Sport for All activity.

Young adults and multisensory time perception: Visual and auditory pathways in comparison.

The brain continuously encodes information about time, but how sensorial channels interact to achieve a stable representation of such ubiquitous information still needs to be determined. According to recent research, children show a potential interference in multisensory conditions, leading to a trade-off between two senses (sight and audition) when considering time-perception tasks. This study aimed to examine how healthy young adults behave when performing a time-perception task. InExperiment 1, we tested the effects of temporary sensory deprivation on both visual and auditory senses in a group of young adults. InExperiment2, we compared the temporal performances of young adults in the auditory modality with those of two samples of children (sighted and sighted but blindfolded) selected from a previous study. Statistically significant results emerged when comparing the two pathways: young adults overestimated and showed a higher sensitivity to time in the auditory modality compared to the visual modality. Restricting visual and auditory input did not affect their time sensitivity. Moreover, children were more accurate at estimating time than young adults after a transientvisual deprivation. This implies thatas we mature, sensory deprivation does not constitute a benefittotime perception, and supports the hypothesis of a calibration process between senses with age.However, more research is needed to determine how this calibration process affectsthe developmental trajectories of time perception.

A Comparison of PKD2L1-Expressing Cerebrospinal Fluid Contacting Neurons in Spinal Cords of Rodents, Carnivores, and Primates.

Cerebrospinal fluid contacting neurons (CSF-cNs) are a specific type of neurons located around the ventricles in the brain and the central canal in the spinal cord and have been demonstrated to be intrinsic sensory neurons in the central nervous system. One of the important channels responsible for the sensory function is the polycystic kidney disease 2-like 1 (PKD2L1) channel. Most of the studies concerning the distribution and function of the PKD2L1-expressing CSF-cNs in the spinal cord have previously been performed in non-mammalian vertebrates. In the present study immunohistochemistry was performed to determine the distribution of PKD2L1-immunoreactive (IR) CSF-cNs in the spinal cords of four mammalian species: mouse, rat, cat, and macaque monkey. Here, we found that PKD2L1-expressing CSF-cNs were present at all levels of the spinal cord in these animal species. Although the distribution pattern was similar across these species, differences existed. Mice and rats presented a clear PKD2L1-IR cell body labeling, whereas in cats and macaques the PKD2L1-IR cell bodies were more weakly labeled. Ectopic PKD2L1-IR neurons away from the ependymal layer were observed in all the animal species although the abundance and the detailed locations varied. The apical dendritic protrusions with ciliated fibers were clearly seen in the lumen of the central canal in all the animal species, but the sizes of protrusion bulbs were different among the species. PKD2L1-IR cell bodies/dendrites were co-expressed with doublecortin, MAP2 (microtubule-associated protein 2), and aromatic L-amino acid decarboxylase, but not with NeuN (neuronal nuclear protein), indicating their immature properties and ability to synthesize monoamine transmitters. In addition, in situ hybridization performed in rats revealed PKD2L1 mRNA expression in the cells around the central canal. Our results indicate that the intrinsic sensory neurons are conserved across non-mammalian and mammalian vertebrates. The similar morphology of the dendritic bulbs with ciliated fibers (probably representing stereocilia and kinocilia) protruding into the central canal across different animal species supports the notion that PKD2L1 is a chemo- and mechanical sensory channel that responds to mechanical stimulations and maintains homeostasis of the spinal cord. However, the differences of PKD2L1 distribution and expression between the species suggest that PKD2L1-expressing neurons may receive and process sensory signals differently in different animal species.

Virtual Reality During Chemotherapy Infusion: An Innovative Intervention in Holistic Nursing Practice.

Patients with cancer receiving infusional chemotherapy show negative symptoms such as worry about their survival, anxiety, anguish, depression, fear, magnified perception of the passage of time, and difficulty managing boredom. Patients also suffer various side effects produced by chemotherapy such as nausea, vomiting, pain, and fatigue, which, together with psychological distress, drastically reduce their quality of life and adherence to therapy with a corresponding reduction in the probability of the individual's survival. Virtual Reality is one of the most innovative and promising digital health interventions, capable of quickly and effectively producing a positive influence on the psychosomatic axis, improving patients' quality of life during chemotherapy. Virtual Reality, through its 3-dimensional multisensory technology, isolates sensory channels from the negative external environment and enables an experience of being physically and psychologically present within virtual scenarios, in which patients can perceive sensations, emotions, cognitions, and interactions as if they really were in different surroundings. This article systematically expounds the scientific conditions necessary for effective, appropriate, and safe implementation of Virtual Reality interventions in holistic nursing practice, describing the underpinning conceptual framework, the types, technological characteristics, methods of use, duration, type of virtual content, and implementation procedure of Virtual Reality.

A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3.

Animal venom peptides represent valuable compounds for biomedical exploration. The venoms of marine cone snails constitute a particularly rich source of peptide toxins, known as conotoxins. Here, we identify the sequence of an unusually large conotoxin, Mu8.1, which defines a new class of conotoxins evolutionarily related to the well-known con-ikot-ikots and 2 additional conotoxin classes not previously described. The crystal structure of recombinant Mu8.1 displays a saposin-like fold and shows structural similarity with con-ikot-ikot. Functional studies demonstrate that Mu8.1 curtails calcium influx in defined classes of murine somatosensory dorsal root ganglion (DRG) neurons. When tested on a variety of recombinantly expressed voltage-gated ion channels, Mu8.1 displayed the highest potency against the R-type (Cav2.3) calcium channel. Ca2+ signals from Mu8.1-sensitive DRG neurons were also inhibited by SNX-482, a known spider peptide modulator of Cav2.3 and voltage-gated K+ (Kv4) channels. Our findings highlight the potential of Mu8.1 as a molecular tool to identify and study neuronal subclasses expressing Cav2.3. Importantly, this multidisciplinary study showcases the potential of uncovering novel structures and bioactivities within the largely unexplored group of macro-conotoxins.

Adaptation to walking direction in biological motion.

The direction that we see another person walking provides us with an important cue to their intentions, but little is known about how the brain encodes walking direction across a neuronal population. The current study used an adaptation technique to investigate the sensory coding of perceived walking direction. We measured perceived walking direction of point-light stimuli before and after adaptation, and found that adaptation to a specific walking direction resulted in repulsive perceptual aftereffects. The magnitude of these aftereffects was tuned to the walking direction of the adaptor relative to the test, with local repulsion of perceived walking direction for test stimuli oriented on either side of the adapted walking direction. The specific tuning profiles that we observed are well explained by a population-coding model, in which perceived walking direction is coded in terms of the relative activity across a bank of sensory channels with peak tuning distributed across the full 360° range of walking directions. Further experiments showed specificity in how horizontal (azimuth) walking direction is coded when moving away from the observer compared to when moving toward the observer. Moreover, there was clear specificity in these perceptual aftereffects for walking direction compared to a nonbiological form of 3D motion (a rotating sphere). These results indicate the existence of neural mechanisms in the human visual system tuned to specific walking directions, provide insight into the number of sensory channels and how their responses are combined to encode walking direction, and demonstrate the specificity of adaptation to biological motion. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Top-down control of exogenous attentional selection is mediated by beta coherence in prefrontal cortex

Salience-driven exogenous and goal-driven endogenous attentional selection are two distinct forms of attention that guide selection of task-irrelevant and task-relevant targets in primates. Top-down attentional control mechanisms enable selection of the task-relevant target by limiting the influence of sensory information. Although the lateral prefrontal cortex (LPFC) is known to mediate top-down control, the neuronal mechanisms of top-down control of attentional selection are poorly understood. Here, we trained two rhesus monkeys on a two-target, free-choice luminance-reward selection task. We demonstrate that visual-movement (VM) neurons and nonvisual neurons or movement neurons encode exogenous and endogenous selection. We then show that coherent beta activity selectively modulates mechanisms of exogenous selection specifically during conflict and consequently may support top-down control. These results reveal the VM-neuron-specific network mechanisms of attentional selection and suggest a functional role for beta-frequency coherent neural dynamics in the modulation of sensory communication channels for the top-down control of attentional selection.

How our hearts beat together: a study on physiological synchronization based on a self-paced joint motor task

Cardiac physiological synchrony is regarded as an important component of social interaction due to its putative role in prosocial behaviour. Yet, the processes underlying physiological synchrony remain unclear. We aim to investigate these processes. 20 dyads (19 men, 21 women, age range 18–35) engaged in a self-paced interpersonal tapping synchronization task under different levels of tapping synchrony due to blocking of sensory communication channels. Applying wavelet transform coherence analysis, significant increases in heart rate synchronization from baseline to task execution were found with no statistically significant difference across conditions. Furthermore, the control analysis, which assessed synchrony between randomly combined dyads of participants showed no difference from the original dyads’ synchrony. We showed that interindividual cardiac physiological synchrony during self-paced synchronized finger tapping resulted from a task-related stimulus equally shared by all individuals. We hypothesize that by applying mental effort to the task, individuals changed into a similar mental state, altering their cardiac regulation. This so-called psychophysiological mode provoked more uniform, less variable fluctuation patterns across all individuals leading to similar heart rate coherence independent of subsequent pairings. With this study, we provide new insights into cardiac physiological synchrony and highlight the importance of appropriate study design and control analysis.

Using digital technologies and innovative methods to improve the reading skills of higher education students

The article is devoted to the problem of activating and improving the reading skills of students using innovative methods and digital technologies. The article explores how modern technologies can stimulate and improve reading, contributing to the active involvement of students in the learning process. The quality of future language teachers' professional training and the possibility of its implementation in the current conditions of digitalisation depend on what and how they read. In particular, the essence and algorithm of applying such innovative technologies as conceptual and figurative reading, collective immersion in a literary text, advertising, colour reading, anti-books, flashbacks are discussed. It is pointed out that such tools allow students to actively engage with the text, expanding their understanding of information, improving concentration and memory. It is proved that conceptual and imaginative reading and collective immersion in a literary text activates various sensory channels, in particular visual imagination, which helps the reader to understand the text more deeply, focus on details, activate emotional and cognitive reactions, and develop creative thinking. It is emphasised that conceptual and imaginative reading and collective immersion in a literary text can be especially useful when reading fiction, descriptions of places or complex concepts, where visualisation can help to understand and remember information. It can help build a shared identity, strengthen social bonds and empathy between group members. The article emphasises that the use of promotional strategies and elements can attract students' attention and make the learning process more engaging and ensure more active participation. One possible approach is to create “advertising campaigns” for specific literary works or authors. This may include creating posters, advertising slogans, anti-books, etc. that will attract students' interest and inspire them to read the book. It is proved that the use of digital technologies and innovative methods to improve the reading skills of students contributes to the formation of professional skills of future language teachers who are able to implement them in their future activities.

Visuo-Tactile Congruence Leads to Stronger Illusion Than Visuo-Proprioceptive Congruence: a Quantitative and Qualitative Approach to Explore the Rubber Hand Illusion.

The Rubber Hand Illusion (RHI) arises through multisensory congruence and informative cues from the most relevant sensory channels. Some studies have explored the RHI phenomenon on the fingers, but none of them modulated the congruence of visuo-tactile and visuo-proprioceptive information by changing the posture of the fingers. This study hypothesizes that RHI induction is possible despite a partial visuo-proprioceptive or visuo-tactile incongruence. With quantitative and qualitative measures, we observed that gradual induction of the sense of body ownership depends on the congruence of multisensory information, with an emphasis on visuo-tactile information rather than visuo-proprioceptive signals. Based on the overall measures, the RHI observed went from stronger to weaker with full congruence; visuo-proprioceptive incongruence and visuo-tactile congruence; visuo-proprioceptive congruence and visuo-tactile incongruence; full incongruence. Our results confirm that congruent visual and tactile mapping is important, though not mandatory, to induce a strong sense of ownership. By changing index finger and thumb postures rather than the rotation of the whole hand, our study investigates the contribution of visuo-proprioception and postural congruence in the field of RHI research. The results are in favor of a probabilistic multisensory integration theory and do not resonate with rules and constraints found in internal body models. The RHI could be illustrated as a continuum: the more multisensory information is congruent, the stronger the RHI.

Implications of a temperature-dependent heat capacity for temperature-gated ion channels

Temperature influences dynamics and state-equilibrium distributions in all molecular processes, and only a relatively narrow range of temperatures is compatible with life-organisms must avoid temperature extremes that can cause physical damage or metabolic disruption. Animals evolved a set of sensory ion channels, many of them in the family of transient receptor potential cation channels that detect biologically relevant changes in temperature with remarkable sensitivity. Depending on the specific ion channel, heating or cooling elicits conformational changes in the channel to enable the flow of cations into sensory neurons, giving rise to electrical signaling and sensory perception. The molecular mechanisms responsible for the heightened temperature-sensitivity in these ion channels, as well as the molecular adaptations that make each channel specifically heat- or cold-activated, are largely unknown. It has been hypothesized that a heat capacity difference (ΔCp) between two conformational states of these biological thermosensors can drive their temperature-sensitivity, but no experimental measurements of ΔCp have been achieved for these channel proteins. Contrary to the general assumption that the ΔCp is constant, measurements from soluble proteins indicate that the ΔCp is likely to be a function of temperature. By investigating the theoretical consequences for a linearly temperature-dependent ΔCp on the open-closed equilibrium of an ion channel, we uncover a range of possible channel behaviors that are consistent with experimental measurements of channel activity and that extend beyond what had been generally assumed to be possible for a simple two-state model, challenging long-held assumptions about ion channel gating models at equilibrium.

Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats

Mechanical sensing Piezo2 channel in primary sensory neurons has been shown contribute to mechanical allodynia in somatic chronic pain conditions. Interstitial cystitis (IC)-associated pain is often triggered by bladder filling, a presentation that mimics the mechanical allodynia. In the present study, we aimed to examine the involvement of sensory Piezo2 channel in IC-associated mechanical allodynia using a commonly employed cyclophosphamide (CYP)-induced IC model rat. Piezo2 channels in dorsal root ganglia (DRGs) was knocked down by intrathecal injections of Piezo2 anti-sense oligodeoxynucleotides (ODNs) in CYP-induced cystitis rats, and mechanical stimulation–evoked referred bladder pain was measured in the lower abdomen overlying the bladder using von Frey filaments. Piezo2 expression at the mRNA, protein, and functional levels in DRG neurons innervating the bladder was detected by RNA-fluorescence in situ hybridization, western blotting, immunofluorescence, and Ca2+ imaging, respectively. We found that Piezo2 channels were expressed on most (> 90%) of the bladder primary afferents, including afferents that express CGRP, TRPV1 and stained with isolectin B4. CYP-induced cystitis was associated with Piezo2 upregulation in bladder afferent neurons at the mRNA, protein, and functional levels. Knockdown of Piezo2 expression in DRG neurons significantly suppressed mechanical stimulation–evoked referred bladder pain as well as bladder hyperactivity in CYP rats compared to CYP rats treated with mismatched ODNs. Our results suggest upregulation of Piezo2 channels is involved in the development of bladder mechanical allodynia and bladder hyperactivity in CYP-induced cystitis. Targeting Piezo2 might be an attractive therapeutic approach for IC-related bladder pain.

A Multisensory Approach to Language Arts The Slingerland Approach in a Californian School

Born in the United States at the end of the last century, the Slingerland Approach is a multisensory method for literacy teaching, at the basis of which lies the assumption that language works based on a complex neurological organization which causes the automatic union of auditory, visual, and kinaesthetic stimuli at a cerebral level. This method offers the exceptional advantage of creating the conditions for the three sensory channels to be associated automatically, thus also connecting the respective association areas in the brain; this gives the child the means to overcome any (possible) difficulties that might occur in the reading-writing skills acquisition process. This article presents the results of a case study conducted at the Stellar Academy for Dyslexics in Newark (CA), a Californian school where the Slingerland Approach is applied to teaching.

Influence of sound and light combined conditions in urban environments on residents' tolerance limits in pre sleep state.

To determine the sound and light combined conditions pollution in urban residential environments at night, this paper comprehensively evaluates cross-visual and auditory sensory channels in the laboratory. Experimental variables include extremum and gradient, and the working state of the participants was determined and verified. A subjective evaluation experiment on 18 combined conditions was carried out by synthesizing real-world data. Results from the sound and light combined conditions experiment show that there are significant differences in the tolerance limits of participants to different content sound variables (p = 0.000 < 0.05, p = 0.033 < 0.05, p = 0.002 < 0.05). Among them, the traffic noise (p = 0.000 < 0.05) has the greatest impact on the tolerance limits of people, followed by birdsong (p = 0.033 < 0.05) and human voice (p = 0.002 < 0.05). There is no difference in the tolerance limits of light pollution (p = 0.288 > 0.05, p = 0.122 > 0.05, p = 0.146 > 0.05) at different color temperatures. The tolerance limits of participants will not be reduced due to the superposition of two interference variables: sound pollution and light pollution. Adding light pollution to sound pollution can increase the tolerance limits of participants, while adding sound pollution to light pollution has no significant effect on the tolerance limits. The study also found that adding light with different color temperatures to the human voice can increase participants' tolerance limit to human voice (1% -2%), indicating that visual elements can change individuals' perception of sound. In addition, the physiological and psychological differences between participants may affect the performance differences of individual participants in sound and light combined conditions.

Early language exposure affects neural mechanisms of semantic representations.

One signature of the human brain is its ability to derive knowledge from language inputs, in addition to nonlinguistic sensory channels such as vision and touch. How does human language experience modulate the mechanism by which semantic knowledge is stored in the human brain? We investigated this question using a unique human model with varying amounts and qualities of early language exposure: early deaf adults who were born to hearing parents and had reduced early exposure and delayed acquisition of any natural human language (speech or sign), with early deaf adults who acquired sign language from birth as the control group that matches on nonlinguistic sensory experiences. Neural responses in a semantic judgment task with 90 written words that were familiar to both groups were measured using fMRI. The deaf group with reduced early language exposure, compared with the deaf control group, showed reduced semantic sensitivity, in both multivariate pattern (semantic structure encoding) and univariate (abstractness effect) analyses, in the left dorsal anterior temporal lobe (dATL). These results provide positive, causal evidence that language experience drives the neural semantic representation in the dATL, highlighting the roles of language in forming human neural semantic structures beyond nonverbal sensory experiences.