Objective: To determine the content of bioactive compounds and antioxidant capacity of the banana passionfruit(Passiflora mollissima) and black cherry (Prunus serotina). Materials and methods: An analytical, experimental, longitudinal and prospective study. The black cherries and bananapassionfruits were collected in the Cusco, Moquegua and Arequipa regions. The content of phenols and flavonoids weredetermined using the Folin–Ciocalteu reagent and aluminum chloride method, respectively. The antioxidant activity wasevaluated using the ferric reducing ability of plasma (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and thiobarbituric acid reactive substance (TBARS) techniques. Albino rats classified into a negative control group, a positive control group andfour experimental groups were used to study the hepatoprotective effect of the fruits. Results: Banana passionfruits from the Cusco region (Quechua) showed the highest concentration of total phenols(584.94 ± 134.62 mg GAE/100 g) and flavonoids (445.62 ± 7.94 mg QE/100 g). Concerning the DPPH radical, the IC50value of banana passionfruits from the Arequipa region (Yunga) was found to be 0.41 ± 0.01 mg/mL. Banana passionfruitsfrom the Cusco region (Quechua) showed the highest FRAP value (8.38 ± 0.32 mmol Fe2+/100 g). Black cherries from theArequipa region (Yunga) had the highest concentration of total phenols (181.81 ± 34.1 mg GAE/100 g) and flavonoids(205.18 ± 77.8 mg QE/100 g). They also showed a significant antioxidant activity regarding the DPPH (2.1 ± 0.01 mg/mL), whilethe antioxidant capacity of black cherries from the Cusco region (Quechua), which was evaluated with the FRAP method,achieved a value of 1.59 ± 0.2 mmol Fe2+/100 g. The observed differences were statistically significant. Banana passionfruitsshowed a better hepatoprotective effect than black cherries.Conclusions: Banana passionfruits from the Cusco region (Quechua) are an important source of antioxidant compoundsand show a high antioxidant capacity (FRAP), while black cherries from the Arequipa region (Yunga) have a high contentof antioxidant compounds and a higher antioxidant capacity (DPPH).