Relevance . In recent years, much attention has been paid development of the use of new types of highly effective environmentally friendly organic fertilizers. Methods and results . The results of monitoring the productivity of grain-grass crop rotation in various natural conditions are shown. The research was carried out in 2013-2019 at the agroecological polygon of All-Russian Research Institute of Reclaimed Lands, within the transect that intersects all the main micro-landscape positions of the course-moraine ridge. In a field where 12 tons of multipurpose compost were once added to the soil for spring wheat, the yield of seven crops of grain-grass crop rotation was determined in various natural conditions of the drained agricultural landscape. Changes in the agro-climatic environment during the research were also taken into account. It was found that the introduction of multipurpose compost and its aftereffect contributes to an increase in the productivity of crop rotation by an average of 0.65 t/ha. Under its influence, crop rotation productivity increased in the central and upper parts of the southern slope, as well as on the top of the moraine hill. The maximum increase from the introduction of multipurpose compost was observed on spring rape and perennial grasses 1 and 3 g. p. In General, the increase in crop productivity was observed only within the southern slope. There is a close correlation between economic indicators and productivity of crop turnover - with the cost of production r = 0.89, with conditional net income r = 0.83, with the availability and level of profitability r = 0.82, and with direct costs slightly weaker than r = 0.71. Using new knowledge about the impact of non-traditional fertilizers in various landscape conditions on the productivity of various crops, it is possible to develop measures for adaptive placement of crops within farms when using