The photocatalytic technique has drawn far-ranging interests in addressing the current issues; however, its property suffers from the limited visible light response and rapid recombination of carriers. To address these issues, two specific approaches have been proposed to enhance the photocatalytic activity: (1) ultrasound-assisted synthesis has been utilized to prepare photocatalysts, resulting in refined grain size, increased specific surface area, and reduced photogenerated carrier recombination; (2) sonophotocatalysis and piezoelectric enhanced photocatalysis have been developed to accelerate the reaction, which utilizes the synergism between ultrasound and light. On one side, sonophotocatalysis generates cavitation bubbles which induce more reactive radicals for redox reactions. On the other side, ultrasound induces deformation of the piezoelectric material structure, which changes the internal piezoelectric potential and improves the photocatalytic performance. Currently, intensive efforts have been devoted to related research and great progress has been reached with applications in pollutant degradation, new energy production, and other fields. This work starts by elucidating the fundamental concept of ultrasound-assisted photocatalyst synthesis and photocatalysis. Then, the synergistic behavior between ultrasonic and light in ultrasonic-assisted photocatalysis has been thoroughly discussed, including pollutant degradation, water splitting, and bacterial sterilization. Finally, the challenge and outlook are investigated and proposed.