The effect of BioVays Sprint and TurMax seed treatment on cellulosolytic activity of leached chernozem under spring wheat in the forest-steppe zone of the Priob'ye region was studied. The experiment was conducted in 2020-2021 in the rhizosphere layer of soil under the Novosibirskaya 31 wheat, which was placed as the second crop after the fallow on the grain forecrop on two backgrounds of nitrogen nutrition - N0 and N60. Cellulosolytic activity of soil was determined by the standard method - by the weight loss of cellulosic cloth introduced into the soil. It was shown that this indicator is influenced by the conditions of the growing season. In 2021, soil cellulosolytic activity in the wheat rhizosphere was higher than in 2020, both in the background without fertilizer application, by 36.6%, and with their application, by 119.54%. Tissue decay increased 1.3-1.4-fold if seeds treated with BioVays Sprint were sown, and 1.3-fold if TurMax was used. On the fertilized background in 2020, the application of TurMax increased the cellulosolytic activity of the soil by 1.6 times, BioVays by 1.3 times. In 2021, seed treatment with BioVays increased the indicator by 2.8 times and with TurMax by 2.2 times. The results obtained do not allow to identify an obvious advantage of one of the two preparations studied, but on their basis, it can be concluded that treatment of seeds with both TurMax and BioVays Sprint is able to increase the cellulolytic activity of the soil, especially against the background of nitrogen fertilizer application.