Materials For Bone Implants Research Articles

Structural and Mechanical Properties of Porous Al2O3-Fap-TiO2 Composite as a Promising Material for Bone Implants

Structural and Mechanical Properties of Porous Al2O3-Fap-TiO2 Composite as a Promising Material for Bone Implants

Biocompatible Composite Materials Based on Porous Hydroxyapatite Ceramics and Copolymer of Lactide and Glycolide

The intensive development of reconstructive surgery and traumatology provides a stable demand for new materials for implants. Of particular interest are materials based on hydroxyapatite, which are chemically close to the elemental composition and structure of bone and have similar bioactive properties. The aim of this work was to obtain porous composite materials based on hydroxyapatite and a copolymer of lactide and glycolide with properties suitable for use as a material for bone implants. The phase and elemental composition of composites was investigated by infrared spectroscopy, X-ray diffraction, and X-ray photoelectronic spectroscopy methods, and it was established how the production process affects the composition of materials. Regularities of the formation of porosity by the methods of low-temperature adsorption of nitrogen, immersion in a liquid (determination of the pore space volume), measurement of the diffusion coefficient through the material (Franz cell), and surface properties of composite materials by the Hammett indicator method, by the lying drop method were revealed. Regularities were established between the surface properties and the composition of materials and their biocompatibility determined using monocytes isolated from human peripheral blood.

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Developing bioactive materials for bone implants to enhance bone healing and bone growth has for years been the focus of clinical research. Barium titanate (BT) is an electroactive material that can generate electrical signals in response to applied mechanical forces. In this study, a BT piezoelectric ceramic coating was synthesized on the surface of a TC4 titanium alloy, forming a BT/TC4 material, and low-intensity pulsed ultrasound (LIPUS) was then applied as a mechanical stimulus. The combined effects on the biological responses of MC3T3-E1 cells were investigated. Results of scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction showed that an uniform nanospheres -shaped BT coating was formed on TC4 substrate. Piezoelectric behaviors were observed using piezoelectric force microscopy with the piezoelectric coefficient d33 of 0.42 pC/N. Electrochemical measures indicated that LIPUS-stimulated BT/TC4 materials could produce a microcurrent of approximately 10 μA/cm2. In vitro, the greatest osteogenesis (cell adhesion, proliferation, and osteogenic differentiation) was found in MC3T3-E1 cells when BT/TC4 was stimulated using LIPUS. Furthermore, the intracellular calcium ion concentration increased in these cells, possibly because opening of the L-type calcium ion channels was promoted and expression of the CaV1.2 protein was increased. Therefore, the piezoelectric BT/TC4 material with LIPUS loading synergistically promoted osteogenesis, rending it a potential treatment for early stage formation of reliable bone-implant contact.

In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants

PLLA-magnesium composites have been widely investigated as potential biodegradable materials for bone implants. Lower/higher corrosion resistance of the crystalized/amorphous magnesium alloys allows tailoring of biodegradability rate. In this work, the amorphous Mg 65 Zn 30 Ca 5 was investigated versus traditional crystalized Mg 65 Zn 30 Ca 5 , and a PLLA-Mg 65 Zn 30 Ca 5 composite has been successfully fabricated using hot injection process. Furthermore, the high corrosion resistance of the amorphous Mg 65 Zn 30 Ca 5 prevented the high alkalization and deterioration of mechanical strength. In addition, the high Zn content intended to improve the glass forming ability, also enhances the anti-bacterial property of the PLLA-Mg 65 Zn 30 Ca 5 composite. The remarkable performance of the PLLA-Mg 65 Zn 30 Ca 5 composite shows its promising application in bone repair and tissue regeneration.

Beta-Titanium Alloy Covered by Ferroelectric Coating–Physicochemical Properties and Human Osteoblast-Like Cell Response

Beta-titanium alloys are promising materials for bone implants due to their advantageous mechanical properties. For enhancing the interaction of bone cells with this perspective material, we developed a ferroelectric barium titanate (BaTiO3) coating on a Ti39Nb alloy by hydrothermal synthesis. This coating was analyzed by scanning electron and Raman microscopy, X-ray diffraction, piezoresponse force microscopy, X-ray photoelectron spectroscopy, nanoindentation, and roughness measurement. Leaching experiments in a saline solution revealed that Ba is released from the coating. A progressive decrease of Ba concentration in the material was also found after 1, 3, and 7 days of cultivation of human osteoblast-like Saos-2 cells. On day 1, the Saos-2 cells adhered on the BaTiO3 film in higher initial numbers than on the bare alloy, but they were less spread, and their initial proliferation rate was slower. These cells also contained a lower amount of beta1-integrins and vinculin, i.e., molecules involved in cell adhesion, and produced a lower amount of collagen I. This cell behavior was attributed to a higher surface roughness of BaTiO3 film rather than to its potential cytotoxicity, because the cell viability on this film was very high, reaching almost 99%. The amount of alkaline phosphatase, an enzyme involved in bone matrix mineralization, was similar in cells on the BaTiO3-coated and uncoated alloy, and on day 7, the cells on BaTiO3 film attained a higher final cell population density. These results indicate that after some improvements, particularly in its roughness and stability, the hydrothermal ferroelectric BaTiO3 film could be promising coating for improved osseointegration of bone implants.

Structural, photoluminescence, antibacterial and biocompatibility features of zinc incorporated hydroxyapatite nanocomposites

The development of bone-implant materials with enhanced bioactivity and biocompatibility has become important in the field of orthopedics. This preparation of nanocomposites of pure Hydroxyapatite (HAp) nanopowder, Hydroxyapatite-Zinc (HAp-Zn), Hydroxyapatite-reduced Graphene oxide (HAp-rGO) and Hydroxyapatite-Zinc-reduced Graphene Oxide (Hap-Zn-rGO) were accomplished using the sol–gel method. The effect of Zn and rGO on the structural, morphological, optical, antimicrobial property and biocompatibility of hydroxyapatite nanopowders are studied. The structural characterization analysed through XRD. The pure HAp and HAp-rGO exhibited hexagonal structure and incorporation of Zn in the host lattice changed this structure into orthorhombic. The average crystallite size ranges from 37 to 51 nm for various nanocomposites. The incorporation of rGO and Zn ions decreased the overall crystallite size. The presence of functional groups in the samples is analyzed and confirmed using FTIR analysis. The SEM photos revealed the structures and morphology of the nanoparticles. The chemical compositions are investigated using Energy Dispersive X-ray analysis (EDX), and all the ratios are in good agreement with the stoichiometry ratio. The photoluminescence emission peaks received around 468 nm and 385 nm and the reasons are discussed in terms of oxygen vacancies and some electronic transition between states. The optical band gap values were redshifted due to the incorporation of rGO with HAp. The in vitro antibacterial activities and biocompatibility of the synthesized pure hydroxyapatite and HAp-Zn-rGO nanocomposite are investigated using Kirby-Bauer antibacterial testing and MTT assay, respectively. The results show that zinc incorporated hydroxyapatite nanocomposites are more toxic against all bacterial strains and did not show any toxicity against living tissues.

Microstructural, cytotoxicity and antibacterial properties of bio-degradable Zn-2Cu-Ti alloy

Scientist uses zinc alloy in the field of bio-medical engineering due its excellent combinations of degradation rates, hemo-compatibility, anti-bacterial activities, etc. The pure zinc metal anyhow suffers lack in strength, mechanical properties due to its hexagonal closed pack structure, which makes it brittle during mechanical working and other operations. In this research we have fabricated a new alloy combination of zinc which includes the addition of copper (Cu) and titanium (Ti) in very smaller proportion through powder metallurgy route. Zn-2Cu-2Ti was the fabricated alloy combination, in which hardness and microstructural properties were studied. The phases observed were CuZn5, with intermetallic phase of TiZn16. Based on the results, the newly made alloy showed good improvement in the bio-compatibility and anti-bacterial activity. Hence we can suggest the material for bone implants and bio-degradable stunts.

Hydroxyapatite Nanoparticles Fortified Xanthan Gum-Chitosan Based Polyelectrolyte Complex Scaffolds for Supporting the Osteo-Friendly Environment.

Nanoparticle-reinforced polymer-based scaffolding matrices as artificial bone-implant materials are potential suitors for bone regenerative medicine as they simulate the native bone. In the present work, a series of bioinspired, osteoconductive tricomposite scaffolds made up of nano-hydroxyapatite (NHA) embedded xanthan gum-chitosan (XAN-CHI) polyelectrolyte complex (PEC) are explored for their bone-regeneration potential. The Fourier transform infrared spectroscopy studies confirmed complex formation between XAN and CHI and showed strong interactions between the NHA and PEC matrix. The X-ray diffraction studies indicated regulation of the nanocomposite (NC) scaffold crystallinity by the physical cues of the PEC matrix. Further results exhibited that the XAN-CHI/NHA5 scaffold, with a 50/50 (polymer/NHA) ratio, has optimized porous structure, appropriate compressive properties, and sufficient swelling ability with slower degradation rates, which are far better than those of CHI/NHA and other XAN-CHI/NHA NC scaffolds. The simulated body fluid studies showed XAN-CHI/NHA5 generated apatite-like surface structures of a Ca/P ratio ∼1.66. Also, the in vitro cell-material interaction studies with MG-63 cells revealed that relative to the CHI/NHA NC scaffold, the cellular viability, attachment, and proliferation were better on XAN-CHI/NHA scaffold surfaces, with XAN-CHI/NHA5 specimens exhibiting an effective increment in cell spreading capacity compared to XAN-CHI/NHA4 and XAN-CHI/NHA6 specimens. The presence of an osteo-friendly environment is also indicated by enhanced alkaline phosphatase expression and protein adsorption ability. The higher expression of extracellular matrix proteins, such as osteocalcin and osteopontin, finally validated the induction of differentiation of MG-63 cells by tricomposite scaffolds. In summary, this study demonstrates that the formation of PEC between XAN and CHI and incorporation of NHA in XAN-CHI PEC developed tricomposite scaffolds with robust potential for use in bone regeneration applications.

Modal Analysis of Femur Bone to Find out the Modal Frequencies of Different Bone Implant Materials

Bio-mechanics is most difficult to carry out on the bone due to the modeling difficulty and complex forces acting on the bones. In this study, we consider human femur bone for modeling analysis. The modal analysis is also important as that of static analysis. We can predict the place at which the fracture occurs. The modal analysis for three different materials is carried out to find the feasible material for bone implants. These materials are Natural bone, AZ31, and Stainless steel 316L. The daily activity such as walking is used as a boundary condition in our study. The femur head is fixed and 750N load is applied at the Knee joint. The results are obtained for these materials. The modal frequencies for Natural Femur bone vary from 0.328Hz to 2.258Hz for Mode1 to Mode 10. The modal frequencies for AZ31 vary from 1.502Hz to 10.292 Hz for Mode1 to Mode 10. The modal frequencies for 316L vary from 3.120Hz to 21.150 Hz for Mode1 to Mode 10. These frequencies are minimal as compared to the natural frequency of the Femur bone. AZ31 is best suited for the fabrication of bone implants because of its lightweight in comparison with 316L material. Also, this is biodegradable in the human body over the period.

Porous silicon carbide coated with tantalum as potential material for bone implants.

Porous silicon carbide (SiC) has a specific biomorphous microstructure similar to the trabecular microstructure of human bone. Compared with that of bioactive ceramics, such as calcium phosphate, SiC does not induce spontaneous interface bonding to living bone. In this study, bioactive tantalum (Ta) metal deposited on porous SiC scaffolds by chemical vapour deposition was investigated to accelerate osseointegration and improve the bonding to bones. Scanning electron microscopy indicated that the Ta coating evenly covered the entire scaffold structure. Energy-dispersive spectroscopy and X-ray diffraction analysis showed that the coating consisted of Ta phases. The bonding strength between the Ta coating and the SiC substrate is 88.4 MPa. The yield strength of porous SiC with a Ta coating (pTa) was 45.8 ± 2.9 MPa, the compressive strength was 61.4 ± 3.2 MPa and the elastic modulus was ∼4.8 GPa. When MG-63 human osteoblasts were co-cultured with pTa, osteoblasts showed good adhesion and spreading on the surface of the pTa and its porous structure, which showed that it has excellent bioactivity and cyto-compatibility. To further study the osseointegration properties of pTa. PTa and porous titanium (pTi) were implanted into the femoral neck of goats for 12 weeks, respectively. The Van-Gieson staining of histological sections results that the pTa group had better osseointegration than the pTi group. These results indicate that coating bioactive Ta metal on porous SiC scaffolds could be a potential material for bone substitutes.

Magnesium Alloys With Tunable Interfaces as Bone Implant Materials.

Magnesium (Mg) based biodegradable materials are a new generation orthopedic implant materials that are intended to possess same mechanical properties as that of bone. Mg alloys are considered as promising substitutes to permanent implants due to their biodegradability in the physiological environment. However, rapid corrosion rate is one of the major constraints of using Mg alloys in clinical applications in spite of their excellent biocompatibility. Approaches to overcome the limitations include the selection of adequate alloying elements, proper surface treatment, surface modification with coating to control the degradation rate. This review focuses on current advances on surface engineering of Mg based biomaterials for biomedical applications. The review begins with a description of corrosion mechanism of Mg alloy, the requirement for appropriate surface functionalization/coatings, their structure-property-performance relationship, and suitability for biomedical applications. The control of physico-chemical properties such as wettability, surface morphology, surface chemistry, and surface functional groups of the coating tailored by various approaches forms the pivotal part of the review. Chemical surface treatment offers initial protection from corrosion and inorganic coating like hydroxyapatite (HA) improves the biocompatibility of the substrate. Considering the demand of ideal implant materials, multilayer hybrid coatings on Mg alloy in combination with chemical pretreatment or inorganic HA coating, and protein-based polymer coating could be a promising technique to improve corrosion resistance and promote biocompatibility of Mg-based alloys.

Synthesis and Properties of Zinc-Modified Hydroxyapatite.

Hydroxyapatites modified with metal ions are the main inorganic components of bone tissue and are approved for use as components for biocomposites and coatings for surgical implants. This study examined prototypes of functional materials for bone implants based on hydroxyapatite modified with zinc ions. Zinc-modified hydroxyapatite was composed and synthesized. Using the XRD method, the phase composition was established. Using SEM, EPMA, and low-temperature nitrogen adsorption (BET) methods, surface properties were investigated. Antibacterial activity and biocompatibility have been established. The studied materials have antimicrobial activity; the samples did not cause significant changes in either the internal organs or the general condition of laboratory animals during the entire experiment.

Static structural analysis of humerus bone to find out the load at which fracture occurs and predict suitable alternative materials for bone implants

Biomechanics deals with the study of the mechanical aspects of the biological objects. The humerus bone is the longest bone of the upper body. In this study, we apply different loads on the humerus bone fixing the proximal (upper end) and applying varying loads on the distal side (lower end) and note down the displacement and maximum stress occurring at different loads for different materials. From this we come to know about the maximum stress at which the bone fails. Model is prepared using ITK-Snap software. MSC Patran software is used for pre processing and post processing, whereas MSC Nastran is used as solver. Analysis is carried out for three different material, natural bone, AZ31, and CP-Ti. It is found that at 85 N natural bone fractures at middle portion of the bone (Deltoid Tuberosity). Bone implants made up of AZ31 materials will be absorbed by the body and no further surgery is required. The stress and displacement are comparatively minimum for this material and it is light weight as compared to CP-Ti. The manufacturing cost is also minimal.

Titanium based biomaterial for bone implants: A mini review

Titanium (Ti) and its alloys are used as promising material for bone implants due to their high strength to weight ratio and good biocompatibility. Many researchers investigated variety of titanium alloys having compatible properties with different types of bones by mixing different elements. Low elastic modulus, non-toxic and bio-compatibility are some important parameters that are investigated in literature. Magnesium (Mg) is well known for its biodegradability. A Ti-Mg composite has emerged as excellent candidate for bone implant due to its low elastic constant, high strength to weight, excellent bio-compatibility. The bio-degradability property of Mg makes a excellent choice to mix with Ti that gives provision for tissue ingrowth. But the deterioration of strength of implant after degradation of Mg puts limitation on content of Mg in Ti-Mg composites. Powder metallurgy is emerged as a suitable manufacturing method of Ti-Mg composites. The more detailed study of process parameters of powder metallurgy is required for enhancement of Ti-Mg properties. Further the research on fracture behavior of implants under fatigue load is also in early stage and there is scope to investigate the life expectancy of implants.

Structural analysis of femur bone to predict the suitable alternative material

This study is based on the biomechanical analysis of femur bone using Finite Element technique. Real life activities are taken as boundary conditions and the weight of a person is considered as load for walking, standing and jumping. For biomechanical analysis, three-dimensional CAD model of human femur bone is modelled from MRI/CT Scan data using ITK-Snap software. Pre-processing and post-processing operations are done using HYPERWORKS whereas the solver is NASTRAN 10.0. Analysis is done using three materials- natural bone material, AZ31 (magnesium alloy), CP Ti (Commercially Pure Titanium Alloy). Comparative study shows that CP-Ti material generates minimum stresses for jumping, standing and walking, which are 5.69, 5.34 and 5.71 MPa respectively. And also minimum displacements for jumping, standing and walking are 0.146, 0.0583 and 0.0623 mm respectively. It is found that AZ31 is the best suited material for Bone implants and as its weight is approximately same as natural bone.

Electrodeposition of Sr-substituted hydroxyapatite on low modulus beta-type Ti-45Nb and effect on in vitro Sr release and cell response.

Beta-type Ti-based alloys are promising new materials for bone implants owing to their excellent mechanical biofunctionality and biocompatibility. For treatment of fractures in case of systemic diseases like osteoporosis the generation of implant surfaces which actively support the problematic bone healing is a most important aspect. This work aimed at developing suitable approaches for electrodeposition of Sr-substituted hydroxyapatite (Srx-HAp) coatings onto Ti-45Nb. Potentiodynamic polarization measurements in electrolytes with 1.67 mmol/L Ca(NO3)2, which was substituted by 0, 10, 50 and 100% Sr(NO3)2, and 1 mmol/L NH4H2PO4 at 333 K revealed the basic reaction steps for OH- and PO43- formation needed for the chemical precipitation of Srx-HAp. Studies under potentiostatic control confirmed that partial or complete substitution of Ca2+- by Sr2+-ions in solution has a significant effect on the complex reaction process. High Sr2+-ion contents yield intermediate phases and a subsequent growth of more refined Srx-HAp coatings. Upon galvanostatic pulse-deposition higher reaction rates are controlled and in all electrolytes very fine needle-like crystalline coatings are obtained. With XRD the incorporation of Sr-species in the hexagonal HAp lattice is evidenced. Coatings formed in electrolytes with 10 and 50% Sr-nitrate were chemically analyzed with EDX mapping and GD-OES depth profiling. Only a fraction of the Sr-ions in solution is incorporated into the Srx-HAp coatings. Therein, the Sr-distribution is laterally homogeneous but non-homogeneous along the cross-section. Increasing Sr-content retards the coating thickness growth. Most promising coatings formed in the electrolyte with 10% Sr-nitrate were employed for Ca, P and Sr release analysis in Tris-Buffered Saline (150 mM NaCl, pH 7.6) at 310 K. At a sample surface: solution volume ratio of 1:200, after 24 h the amount of released Sr-ions was about 30-35% of that determined in the deposited Srx-HAp coating. In vitro studies with human bone marrow stromal cells (hBMSC) revealed that the released Sr-ions led to a significantly enhanced cell proliferation and osteogenic differentiation and that the Sr-HAp surface supported cell adhesion indicating its excellent cytocompatibility.

Heat-curing polylactide for bone implants: Preparation and investigation on properties relevant to degradation

Several processes have been used to produce polylactide for bone replacement. The challenge remains, however, to produce these devices by a simpler and more economical process. In this study, a method of combining powder and liquid parts was introduced. Star-shaped polylactides with molecular weights ranging from 3 to 16 kg/mol were synthesized and blended with a linear polylactide (Mw = 188 kg/mol) using the technique of emulsion solvent evaporation. The blends in a form of spherical powder were characterized by scanning electron microscopy, gel permeation chromatography, and particle size analysis. The heat-curing polylactide was fabricated by mixing the powder with triethylene glycol dimethacrylate, molded, and then heated in a hot water bath to solidify. The effects of powder composition in terms of amount and molecular weight of the star-shaped polylactide on mechanical properties were investigated. The results showed an increase in flexural strength with increase in the amount of star-shaped polylactide. The powder comprised star-shaped polylactide having the molecular weight of 10,770 g/mol, not less than 80wt%, offered the fabricated heat-curing polylactide with high strength ranging from 95 to 100 MPa. This formulation was further incorporated with hydroxyapatite to improve biocompatibility and subjected to degradation at 37°C. Mechanical test and weight loss determination together with biological test were conducted at certain times during degradation of the materials. Both materials with and without hydroxyapatite showed mechanical stability upon degradation for at least 6 months, but the one with hydroxyapatite revealed significantly better bioactivity at the end of 1-year follow-up study, making it the most promising material for bone implants.

3D Printing of Bioceramics for Bone Tissue Engineering.

Bioceramics have frequent use in functional restoration of hard tissues to improve human well-being. Additive manufacturing (AM) also known as 3D printing is an innovative material processing technique extensively applied to produce bioceramic parts or scaffolds in a layered perspicacious manner. Moreover, the applications of additive manufacturing in bioceramics have the capability to reliably fabricate the commercialized scaffolds tailored for practical clinical applications, and the potential to survive in the new era of effective hard tissue fabrication. The similarity of the materials with human bone histomorphometry makes them conducive to use in hard tissue engineering scheme. The key objective of this manuscript is to explore the applications of bioceramics-based AM in bone tissue engineering. Furthermore, the article comprehensively and categorically summarizes some novel bioceramics based AM techniques for the restoration of bones. At prior stages of this article, different ceramics processing AM techniques have been categorized, subsequently, processing of frequently used materials for bone implants and complexities associated with these materials have been elaborated. At the end, some novel applications of bioceramics in orthopedic implants and some future directions are also highlighted to explore it further. This review article will help the new researchers to understand the basic mechanism and current challenges in neophyte techniques and the applications of bioceramics in the orthopedic prosthesis.

Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications.

In maxillofacial surgery, there is a significant need for the design and fabrication of porous scaffolds with customizable bionic structures and mechanical properties suitable for bone tissue engineering. In this paper, we characterize the porous Ti6Al4V implant, which is one of the most promising and attractive biomedical applications due to the similarity of its modulus to human bones. We describe the mechanical properties of this implant, which we suggest is capable of providing important biological functions for bone tissue regeneration. We characterize a novel bionic design and fabrication process for porous implants. A design concept of "reducing dimensions and designing layer by layer" was used to construct layered slice and rod-connected mesh structure (LSRCMS) implants. Porous LSRCMS implants with different parameters and porosities were fabricated by selective laser melting (SLM). Printed samples were evaluated by microstructure characterization, specific mechanical properties were analyzed by mechanical tests, and finite element analysis was used to digitally calculate the stress characteristics of the LSRCMS under loading forces. Our results show that the samples fabricated by SLM had good structure printing quality with reasonable pore sizes. The porosity, pore size, and strut thickness of manufactured samples ranged from (60.95± 0.27)% to (81.23±0.32)%, (480±28) to (685±31) μm, and (263±28) to (265±28) μm, respectively. The compression results show that the Young's modulus and the yield strength ranged from (2.23±0.03) to (6.36±0.06) GPa and (21.36±0.42) to (122.85±3.85) MPa, respectively. We also show that the Young's modulus and yield strength of the LSRCMS samples can be predicted by the Gibson-Ashby model. Further, we prove the structural stability of our novel design by finite element analysis. Our results illustrate that our novel SLM-fabricated porous Ti6Al4V scaffolds based on an LSRCMS are a promising material for bone implants, and are potentially applicable to the field of bone defect repair.

Advancement of the artificial amorphous-crystalline structure of laser cladded FeCrMoCB on nickel-free stainless-steel for bone-implants

Abstract This research proposes the development of amorphous-crystalline FeCrMoCB layer as a promising biomaterial for bone-implant applications. The FeCrMoCB amorphous powder was laser cladded on nickel-free stainless-steel (Cronidur30) using three laser specific energies (Es) levels (31.8, 27.5 and 23.4 J/mm2) to attain different amorphous contents. The amorphous-crystalline structure and the microstructure were investigated using X-ray diffraction and scanning electron microscope, respectively. Later, the corrosion rate and the wear rate in simulated body fluids (SBF) were evaluated to investigate the advancement of the artificial amorphous-crystalline structure of laser cladded FeCrMoCB metallic glass (MG) composite via electrochemical corrosion test and pin-on-disc test, respectively. The hardness and Young's modulus (E) were acquired using nanoindentation measurement while the cytocompatibility was evaluated by MTT assay using MC3T3 cell-lines. The material characterization showed that increasing of Es resulted in decreasing the amorphous phase and increasing the crystalline phase. The laser cladded FeCrMoCB MG composite showed significant enhancement of the corrosion and wear resistance in SBF implying longer implant service time. This advancement behavior is not only superior to the uncoated substrate, but also compared to other biomaterials including Zr-based MG, Ti6Al4V, and CoCrMo alloys in SBF. Finally, the FeCrMoCB MG composite showed an acceptable cytocompatibility behavior bringing promising enhanced characteristics for bone-implant material.