Abstract
The intensive development of reconstructive surgery and traumatology provides a stable demand for new materials for implants. Of particular interest are materials based on hydroxyapatite, which are chemically close to the elemental composition and structure of bone and have similar bioactive properties. The aim of this work was to obtain porous composite materials based on hydroxyapatite and a copolymer of lactide and glycolide with properties suitable for use as a material for bone implants. The phase and elemental composition of composites was investigated by infrared spectroscopy, X-ray diffraction, and X-ray photoelectronic spectroscopy methods, and it was established how the production process affects the composition of materials. Regularities of the formation of porosity by the methods of low-temperature adsorption of nitrogen, immersion in a liquid (determination of the pore space volume), measurement of the diffusion coefficient through the material (Franz cell), and surface properties of composite materials by the Hammett indicator method, by the lying drop method were revealed. Regularities were established between the surface properties and the composition of materials and their biocompatibility determined using monocytes isolated from human peripheral blood.
Highlights
Accepted: 22 April 2021The problem of reconstruction of bone defects resulting from trauma, surgical interventions and pathological changes in the body is relevant at the present time
Of particular interest are materials based on hydroxyapatite, which are chemically close to the elemental composition and structure of bone and have similar bioactive properties
The aim of this work was to obtain porous composite materials based on hydroxyapatite and a copolymer of lactide and glycolide with properties suitable for use as a material for bone implants
Summary
Accepted: 22 April 2021The problem of reconstruction of bone defects resulting from trauma, surgical interventions and pathological changes in the body is relevant at the present time. Hydroxyapatite (HA) is one of the most suitable substances for its use as the main component of the material for the restoration of bone tissue, it is contained in the bone composition from 50 to 95% [1]. Bioceramics of phosphates are widely used as a biomaterial with high biocompatibility and integration into bone tissue, since it is the closest in composition to the mineral part of bones [2,3]. Taking into account the existing disadvantages of certain groups of materials, low fracture toughness of ceramics and insufficient osteoconductivity of polymeric materials, we can conclude that the way out is to obtain composite materials that allow to level the disadvantages and enhance the advantages of individual components. Copolymer of lactide and glycolide may act as part of the materials as a component of replacing bone collagen.
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