Jones Dole Equation Research Articles

Study of Molecular Interaction for Antibiotic Drug with Sugar Solutions at Different Temperature

The interactions of drug amoxicillin with maltose or galactose solutions with a variation of temperature have been discussed by taking in the volumetric and viscometric procedures. Physical properties [densities (ρ) and viscosities (η)] of amoxicillin (AMOX) aqueous solutions and aqueous solutions of two type saccharides (maltose and galactose 0.05m) have been measured at T = (298.15, 303.15 and 308.15) K under atmospheric pressure. The apparent molar volume (ϕv cm3mole-1) has been evaluated from density data and fitted to a Redlich-Mayer equation. The empirical parameters of the Mayer-Redlich equation and apparent molar volume at infinite dilution Ø°v were explicated in terms of interactions from type solute-solvent and solute–solute interactions. Transfer molar volume ΔtraØ°v for AMOX from water to aqueous maltose and galactose solutions were calculated to comprehend different interactions in the ternary solutions. Limiting apparent molar expansibility (Ø°E) and Hepler’s coefficient was also calculated to indicate the structure making ability of AMOX in the ternary solutions. Jones–Dole coefficient B and A have been calculated from viscosity data by employing the Jones–Dole equation. The free energy of activation of viscous flow per mole of the solute (Δμ°2*) and solvent (Δμ°1*) have been explained on the basis of the Eyring and Feakins equation.

Physicochemical properties of dilute aqueous solutions of 1-Ethyl-3-Methylimidazolium Ethylsulfate, 1-Ethyl-3-Methylimidazolium Methylsulfate, 1-Ethyl-3-Methylimidazolium Tosylate and 1, 3-Dimethylimidazolium Methylsulfate at different temperatures and at atmospheric pressure

This work presents the experimental data on thermophysical properties of aqueous solutions of imidazolium-based ionic liquids (ILs) such as 1-Ethyl-3-Methylimidazolium Ethylsulfate [EMIM][EtSO4], 1-Ethyl-3-Methylimidazolium Methylsulfate [EMIM][MeSO4], 1-Ethyl-3-Methylimidazolium Tosylate [EMIM][Tos], and 1,3-Dimethylimidazolium Methylsulfate [MMIM][MeSO4] in water at different temperatures. Many researchers have studied imidazolium based ILs in different solvents but there is scarcity of data in dilute region. So the aim of this work is to understand the interactions between imidazolium based ILs and water in dilute region. To understand the ion-ion and ion–solvent interactions between IL and water, the thermophysical properties such as density (ρ), speed of sound (u), and viscosity (η) have been measured at temperatures T = (298.15, 303.15, 308.15 and 313.15) K and at atmospheric pressure. The properties like apparent molar volume, limiting apparent molar volume and coefficient of thermal expansion have been derived from the density data. The speeds of sound and density data were combined to evaluate isentropic and isothermal compressibilities. Using Jones-Dole equation, the viscosity A and B coefficients have been determined. The influence of IL cation chain length, different anions and temperature on the sign, magnitude of BV (the deviation parameter from Debye-Hückel theory) and on viscosity B-coefficient has been discussed.

Viscometric and spectroscopic studies on interactions of glycine with aqueous buffer solutions

Abstract To study the solvation and hydration behavior of glycine, viscosity measurements have been carried out for glycine in water of pH = (1.00, 7.40 and 14.00) and in different concentrations (0.1, 0.5 and 1.0) M of aqueous potassium/sodium phosphate buffer (KPB/NaPB) solutions of pH = (1.00, 7.40 and 14.00) at different temperatures, T = (298.15, 308.15, 310.15 and 318.15) K. Viscosity B-coefficients for glycine in water and in aqueous buffer solutions have been obtained at different temperatures using Jones-Dole equation. Viscosity B-coefficients of transfer (∆trB) values have been calculated from viscosity B-coefficient data. Both positive and negative viscosity B-coefficients of transfer have been observed in the studied system. The Gibbs energies of activation for viscous flow per mole of solvent (∆μ1o) and per mole of solute (∆μ2o) have been calculated and discussed in terms of transition state theory. Solvation (Sn) and hydration (nH) numbers have also been calculated from these data. The results have been discussed in terms of solute-solvent and solute-solute interactions in these systems. The structure-making/breaking ability of glycine has been discussed in terms of the sign of dB/dT. UV absorption spectra for glycine in aqueous KPB solutions has been recorded. All the viscometric and spectroscopic parameters have been used to explore various interactions that may arise in presently investigated ternary solutions.

Molecular interactions of drug semicarbazide hydrochloride in aqueous-D-xylose/L-arabinose solutions at different temperatures: Volumetric, acoustic and viscometric study

The interactions of drug semicarbazide hydrochloride in water and in aqueous-carbohydrate (D-xylose/L-arabinose) solutions from their physicochemical behaviour are studied. Density, ρ, ultrasonic speed, u and viscosity, η of the drug semicarbazide hydrochloride in water and in aqueous-D-xylose/L-arabinose (5 wt% and 10 wt% of D-xylose/L-arabinose in water, w/w) solvents were measured as functions of concentrations at temperatures, T = (293.15 – 318.15) K and at atmospheric pressure, p = 101 kPa. The measured data have been utilized to calculate various properties like the apparent molar volume, Vφ from density measurements while apparent molar compressibility, Ks,ϕ, acoustic impedance, Z and intermolecular free length, Lf from ultrasonic speed measurements. The values obtained from these parameters indicate strong solute–solvent interactions within the solutions. The viscosity data have been analyzed using Jones-Dole equation and coefficients A and B were evaluated. The temperature derivative of B-coefficient, dB/dT together with activation parameters of viscous flow have also been determined. The results are discussed in terms of hydrophilic-hydrophilic and hydrophilic-hydrophobic interactions in these systems along with the structure breaking/making ability of the drug.

Kinetics of static immersed leaching of low-grade sea-type evaporites based on theoretical and experimental investigation of unsteady-state mass transfer

In the immersed leaching process of low-grade sea-type evaporate wastes, the relative proportions of the solute contents in the mining brine continuously change over time, which makes the composition of the brine from leaching unpredictable. This strange phenomenon has been lacking a reasonable explanation for many years. To investigate this issue, the immersed dissolution and diffusion experiments of four typical sea-type evaporites NaCl, Na2SO4·10H2O, MgCl2·6H2O, and MgSO4·7H2O were performed in laboratory and pilot scale, respectively. Based on Fick’s second law, Stokes–Einstein equation, Thomas equation, Jones–Dole equation etc., a mathematical model was established to describe the mass transfer process. The results show that the unsteady-state mass transfer of each salt component in static water has three stages: linear fast mass transfer before the first 720 h, nonlinear unsteady-state mass transfer from 720 h to 7000 h, and pseudo-linear slow mass transfer after 7000 h. In every stage, the diffusion of Na+ and Cl− was faster than that of Mg2+ and SO42−, respectively, but their local diffusion rates were changing at different magnitudes, and their local viscosity and local mass transfer coefficients also varied to a great extent and underwent dynamic changes. At a distance of 60 mm from the evaporite-brine interface, the saturation degree reached by NaCl is approximately 1.23, 1.50, and 1.58 times that of Na2SO4, MgCl2, and MgSO4 when the diffusion time is 720 h, respectively. The local mass transfer coefficients of NaCl can reach approximately 1.48, 3.01, and 2.85 times that of Na2SO4, MgCl2, and MgSO4, respectively. The aforementioned results reveal that the unconstant change of the ratios of solute contents of the leaching brine resulted from the dynamic change in the local mass transfer rate of each component. The difference in concentration between Na+ and Mg2+ ions becomes more apparent when the diffusion distance is below 90 mm within the first 120 h of the diffusion time. Under the comprehensive influence of these factors, when NaCl or MgSO4·7H2O is present in the mixed evaporites, as the leaching time increases, the Na+/Mg2+ ratio changes continuously in the leaching brine owing to variations in the dissolution rate and magnitude of changes of components such as NaCl and MgSO4. Therefore, brines with different solute content ratios can be obtained as the leaching process proceeds.

Borate Species, Volumetric and Transport Properties of Aqueous Lithium Metaborate Solution from 288.15 to 318.15 K

The present work reports acidity (pH), Ranman spectrum, densities (ρ) and viscosity (η) of aqueous lithium metaborate solution at different temperatures. Polyborate distributions in aqueous LiB(OH)4 solution were calculated using measured pH values and literature equilibrium constants. Combining Raman spectra and polyborate distributions result, the polyborate species were ascertained in solution. The apparent molar volumes (Φv), standard molar volumes ($$\Phi _{v}^{0}$$), apparent molar expansibilities ($$\Phi _{E}^{0}$$), and coefficient of thermal expansion (α) in aqueous lithium metaborate solution have been calculated from the density data. The viscosity data have been analyzed by Jones–Dole equation. Different thermodynamic parameters have been used to explore solute–solute, solute–solvent interactions and effect of concentration and temperature. All the parameters calculated from density and viscosity indicate that the lithium metaborate is water structure breaker.

Transport and optical properties of 1-octyl 3-methylimidazolium bromide ionic liquid in water + Ethanol/1-propanol mixtures at T = (298.2, 308.2 and 318.2) K

In this work, viscosities (η), conductivities (Ʌ) and refractive index (nD) for the ternary systems of 1-octyl-3-methylimidazolium bromide [OMIm]Br ionic liquid in the Ethanol/1-propanol+water mixtures were measured in different mass fractions of alcohol in water (w/w% = wAlcohol/wmixture = 0, 10, 20 and 30%) at T = (298.2, 308.2 and 318.2) K. The viscosity data was analyzed using jones-dole equation to derive the viscosity B-coefficient which indicates the solute-solvent interactions. The temperature dependence of the viscosity was described by fluidity equation. Ion association constants (Ka) and limiting molar conductivities (Ʌ0) of [OMIm]Br were obtained by using Fuoss–Onsager equation based on conductivity measurements. In addition, refractive index (nD) of [OMIm]Br were measured for the binary and ternary water+[OMIm]Br + Ethanol/1-propanol mixtures. The obtained results were compared to the predicted values using the Heller equation. Excess refractive index (nDE) for binary and ternary mixtures and regression parameters of the Redlich–Kister and Cibulka equation were obtained at different temperatures.

Solution properties of an antidiabetic drug metformin hydrochloride in aqueous urea and thiourea solutions: A physicochemical study

Densities, speeds of sound and viscosities of metformin hydrochloride in water and in (0.025, 0.050 and 0.075) mol. kg−1 aqueous urea and thiourea solutions have been measured at T = (293.15, 298.15, 303.15, 308.15 and 313.15) K. From density data, apparent molar volume, Vϕ, limiting apparent molar volume, V0ϕ, slope, Sv, partial molar volume of transfer, ∆trV0ϕ, limiting apparent molar expansivity, E0ϕ, and Hepler's constant, (∂2V0ϕ/∂T2)P, have been measured. The apparent molar isentropic compression, Kϕ,s, limiting apparent molar isentropic compression, K0ϕ,s, slope, Sk, limiting apparent molar isentropic compression of transfer, ∆trK0ϕ,s and hydration number, nH have been calculated from speed of sound data. The viscosity data has been analyzed using Jones–Dole equation for viscosity B-coefficients and viscosity B-coefficients of transfer ΔtrB. The results have been interpreted in terms of solute-solvent and solute-solute interactions and structure making/breaking ability of solute in the aqueous solution of urea/thiourea.

Interactions of Cetyltrimethylammonium Bromide with 1,3-Dioxolane in Water: A Study of Viscosity and Volumetric Properties

Densities and viscosities of ternary mixtures containing cetyltrimethyl ammonium bromide (CTAB) in aqueous solution of 1,3-dioxolane have been measured at 5 K intervals from 298.15 to 313.15 K and at atmospheric pressure. The experimental results of viscosity and density have been analyzed by using Jones-Dole equation and Masson equation. The values of constants A and B of Jones-Dole equation have been interpreted in terms of solute-solute and solute-solvent interactions. The standard partial molar volume,Vφ 0 at infinite dilution were determined from Masson equations. The structure making/breaking capacity of solute is interpreted with the help of Helper equation. The positive value of Helper′s constant (∂2Vφ 0/∂T2)p and the negative value of dB/dT shows that CTAB in studied organic solvent predominantly acts as a structure-maker.

Physical properties of switchable-hydrophilicity solvent systems: Triethylamine, water and carbon dioxide

Physical properties like density, viscosity, refractive index and conductivity of switchable hydrophilicity solvent (SHS)systems (triethylamine (TEA), water, and carbon dioxide) as a function of concentration at different temperatures ranging from 283.15 K to 308.15 K have been determined. These data have been used to calculate apparent molar volume, limiting apparent molar expansibility of solute and the relative viscosity of the studied solutions. The viscosity coefficients B have been determined from the Jones-Dole equation. The limiting apparent molar volumes and experimental slopes (Av) derived from the Masson equations have been interpreted in terms of solute-solute and solute-solvent interactions. From the volumetric and viscometric data, the structural effect of TEAH-bicarbonate salt in aqueous solvent has been discussed.

Thermophysical properties of glycine and glycylglycine in aqueous tartaric acid at different temperatures: Volumetric, acoustic and viscometric studies

Thermophysical properties like density, ultrasonic velocity and viscosity of glycine, glycylglycine in water and in (0.1942, 0.3773, 0.5504 and 0.7142) mol٠kg−1 aqueous tartaric acid solutions as a function of concentration at different temperatures ranging between (298.15 and 318.15) K have been determined. These data have been utilized to calculate apparent molar volume (φv), apparent molar isentropic compressibility (φk), and viscosity B-coefficient values of the studied solutions. The partial molar volumes (φv0), partial molar isentropic compressibility (φk0) and experimental slopes (Sv* and Sk*) derived from the Mason equations have been interpreted in terms of solute-solute and solute -solvent interactions. The viscosity coefficients A and B have been determined from the Jones-Dole equation. From the volumetric and viscometric data, hydration number (nH) has been calculated and further, the structural effects of glycine, glycylglycine in tartaric acid solution has been discussed. The results were explained in terms of structure making and structure breaking properties.

Volumetric, acoustic and viscometric investigation of ceftriaxone disodium in aqueous solutions of 1-propanol and 2-propanol

The extraction and purification of ceftriaxone disodium from aqueous solution carried out with organic solvents. Therefore volumetric, acoustic and viscometric properties of ceftriaxone disodium in aqueous solutions of 1–propanol and 2–propanol were investigated at T/K = (288.15–308.15). The apparent molar volumes and isentropic compressibility values in dilute region were fitted to Redlich-Mayer equation. The infinite dilution apparent molar transfer volumes, ΔtrVφo, were often negative and increased with increasing the concentration of 1–propanol and 2–propanol. This behaviour reveals that there are strong ionic-polar interactions between ions of CFNa and 1–propanol or 2–propanol with respect to water; because the polarizability of 1–propanol and 2–propanol is greater than those of water. The apparent molar isentropic compressibility at infinite dilution, κφo, of CFNa in the aqueous solutions of 1–propanol and 2–propanol are higher than those of pure water. Therefore the CFNa was dehydrated with addition of 1–propanol or 2–propanol. To obtain viscosity B and D coefficients, the viscosities data were fitted to the Jones-Dole equation. The viscosity B-coefficient of CFNa in the aqueous solutions of 1–propanol and 2–propanol was lower than those of CFNa pure water. Therefore it can be concluded that CFNa solvated in water rather than the aqueous solutions of 1–propanol and 2–propanol.

Probing aqueous electrolytes with Fourier Spectrum Pulse-Echo technique

The nature of variations of ultrasonic wave velocity(v) and attenuation constant(α) with the concentration(c) in aqueous solutions of NaCl, KCl and CsCl are investigated at room temperature(25 °C) at 1 MHz and 2 MHz wave frequency. Fourier Spectrum Pulse-Echo (FSPE) technique is used to achieve better accuracy in measurement, particularly for α measurement. Abrupt changes in the values of v and α are noticed at particular solution concentrations for NaCl and KCl but, for CsCl, almost smooth variation in v is observed over the whole concentration range both for 1 MHz and 2 MHz. The nature of variation in v and α in these solutions are analyzed in view of other spectroscopic studies. The well-known Jones-Dole equation that explains the viscosity (η) variation in many electrolyte solutions, offers satisfactory fits to the experimental velocity variation with parameter values characteristics of the sample.

Effect of ionic liquids, 1-alkyl-4-methylpyridinium bromides on the volumetric, acoustic and viscometric behaviour of aqueous ceftriaxone sodium solutions

Ionic liquids have recently been of growing significance in pharmaceutical applications. The effect of some ionic liquids on the thermodynamic and transport characteristics of ceftriaxone sodium (CFNa) drug has been studied in this research. Density, speed of sound, and viscosity of CFNa in 1-butyl-4-methylpyridinium bromide, 1-hexyl-4-methylpyridinium bromide and 1-octyl-4-methylpyridinium bromide aqueous solutions have been measured at T/K = (288.15–308.15). Apparent molar volumes at infinite dilution, transfer apparent molar volume, apparent molar isentropic compressibility at infinite dilution and B and D viscosity coefficients of ceftriaxone sodium have been calculated and discussed with regards to solute-solute and solute-solvent interactions using experimental data. The apparent molar volumes and isentropic compressibility values in dilute region were acquired through fitting density and speed of sound data to Redlich-Mayer equation and the viscosity B and D coefficients values were given by Jones-Dole equation.

Thermodynamic and solution properties of sodium valporate in aqueous solution and its interaction with cetyl trimethylammonium bromide (CTAB)

This manuscript reports the volumetric, viscometric and aggregation properties of sodium valporate in aqueous solution. The interaction of drug with cationic surfactant (CTAB) was also studied. From volumetric study, partial molar volume, Hepler's constant, partial molar expansivity and isobaric thermal expansion coefficient were calculated while from viscometric study, the constants of Jones-Dole equation and thermodynamic parameters of viscous flow like free energy change, entropy change and enthalpy change were calculated. Critical micelle concentration of drug at four different temperatures was measured by surface tension and electrical conductivity measurements. The data was used to calculate surface excess concentration and thermodynamic parameters for the micellization process i.e. free energy of adsorption, free energy, entropy and enthalpy of micellization. Spectroscopic study of the drug/surfactant interaction was helpful to calculate partition coefficient, free energy of partition, binding constant and free energy of binding.

Viscometric Studies of Cu(II) Surfactants Derived from Mustard Oil in Benzene at 303.15 K

AbstractThe viscosity, specific viscosity, and fluidity of Cu(II) surfactant complexes derived from mustard oil with urea/thiourea/2-amino-6-chloro benzothiazole in a non-aqueous solvent has been determined at a constant temperature of 303.15 K. The results were used to determine the critical micelle concentration (CMC), soap complex-solvent interactions and the effect of chain length of the surfactant molecule on various parameters. The conclusions with regard to solute-solute and solute-solvent interaction have been discussed in terms of well-known Moulik and Jones-Dole equations. The effect of surfactant concentration on the viscosity of the solution in non-polar solvent has been discussed. The observations suggested that the structure breaking effect by the solute on the solvent molecules is more prominent above CMC as compared to below CMC after the formation of the micelles. This information plays a role in various industrial and biological applications.

DIFFERENT PHYSICAL PROPERTIES OF FEW AMINO ACIDS FOR FIVE DIFFERENT TEMPERATURES IN AQUEOUS SODIUM ACETATE SOLUTION

In this paper we have considered two basic amino acids and obtained the physical property like ultrasonic velocity. Though the main focus of the paper is ultrasonic velocity, but other physical parameters like adiabatic compressibility, apparent molal compressibility, apparent molal volume, limiting apparent molal compressibility, limiting apparent molal volume and their constants, transfer adiabatic compressibility, transfer volume, and viscosity B-coefficient of Jones-Dole equation are obtained in sodium acetate solution. From our study, it is quite clear that temperature has a significant effect on the structure of the amino acids. We have considered two basic amino acids, namely, L-leucine and L-glutamine under the influence of five different temperatures as 300K, 305K, 310K, 315 and 320K.

Investigation of electrolytes of the vanadium redox flow battery (VII): Prediction of the viscosity of mixed electrolyte solution (VOSO4 + H2SO4 + H2O) based on Eyring’s theory

Viscosities of ternary mixtures of VOSO4 + H2SO4 with water were measured across the entire range of total ionic strength (IT = 1 to 11) mol·kg−1 and over a temperature range of (283.15–318.15) K. The viscosity B-coefficients of the binary aqueous were determined from Jones-Dole equation. Using the B-coefficients, the activation parameters for viscous flow of the solutes were further evaluated. On the basis of Eyring’s equation, a semi-empirical method to estimate the viscosity for concentrated and mixed electrolyte solutions was put forward. The estimated viscosity values of VOSO4 + H2SO4 + H2O are in quite good agreement with the corresponding experimental results with the average absolute relative deviation of 0.96%.

Solution and Surface Properties of Metformin Hydrochloride in Aqueous Solution and Its Interaction with Amino Acids and Anionic Surfactant, Sodium Dodecyl Sulphate

This manuscript reports critical micelle concentration of metformin hydrochloride in aqueous solution which was determined by electrical conductivity, surface tension and refractive index measurements. From conductometric and surface tension data, different parameters were calculated which include surface excess concentration, area per molecule, dissociation constant and free energy of adsorption. Thermodynamic parameters like free energy of micellization, enthalpy of micellization and entropy of micellization were also calculated. The effect of change in pH on the CMC of drug was studied in pH range of 2–9. Three amino acids, i.e. glycine, tyrosine and tryptophane, were used to study their effect on CMC of drug. The interaction of this drug with two common surfactants, i.e. sodium dodecyl sulphate (SDS) and cetyl trimethylammonium bromide, was also studied with the help of UV–visible spectroscopy and conductivity measurements. Viscometric study was carried out to find the constants of Jones–Dole equation which are helpful to find the different types of interactions in solution. The results showed the spontaneous nature of adsorption of drug at air solution interface and spontaneous nature of micellization, becoming more spontaneous at elevated temperature. Strong interaction of drug with anionic surfactant SDS was observed. The increase in pH decreased CMC of drug, but higher CMC was found at pH of 7. The amino acids affect the CMC of the drug in different ways. Viscometric study showed the hydrophobic interaction of drugs with the solvent molecules.

Diverse Interactions of N-Methyl Glycine in Aqueous Paracetamol Solution with the Manifestation of Solvation Consequences

The apparent molar volume (ϕV) and viscosity B-coefficient of N-methyl glycine of 0.01 M, 0.02 M and 0.03 M aqueous solutions have been estimated in presence of paracetamol at three temperatures namely 298.15 K, 303.15 K and 308.15 K from physicochemical study such as density (ρ) and viscosity (η) and refractive index measurements and 1 H NMR spectroscopy. The volumetric study was employed to evaluate limiting apparent molar volumes (ϕ V 0 ) and experimental slopes (S V *) by using Masson equation for explaining solute–solvent and solute–solute interactions, respectively. The nature of group interactions between the solute, solvent and co-solute have been examined from limiting apparent molar volumes of transfer (Δϕ V 0 ) values. The viscosity data were employed to determine viscosity A and B coefficients from Jones–Dole equation and the resulting parameters were used to examine the solute–solute and solute–solvent interactions in the solutions. Molar refraction values calculated from refractive indices by applying Lorentz–Lorenz equation were used to depict the intermolecular interactions between N-methyl glycine and paracetamol in their aqueous solution. However, the 1 H NMR spectroscopy supports the existence of diverse interactions concretely.