Effect of ionic liquids, 1-alkyl-4-methylpyridinium bromides on the volumetric, acoustic and viscometric behaviour of aqueous ceftriaxone sodium solutions

Abstract

Ionic liquids have recently been of growing significance in pharmaceutical applications. The effect of some ionic liquids on the thermodynamic and transport characteristics of ceftriaxone sodium (CFNa) drug has been studied in this research. Density, speed of sound, and viscosity of CFNa in 1-butyl-4-methylpyridinium bromide, 1-hexyl-4-methylpyridinium bromide and 1-octyl-4-methylpyridinium bromide aqueous solutions have been measured at T/K = (288.15–308.15). Apparent molar volumes at infinite dilution, transfer apparent molar volume, apparent molar isentropic compressibility at infinite dilution and B and D viscosity coefficients of ceftriaxone sodium have been calculated and discussed with regards to solute-solute and solute-solvent interactions using experimental data. The apparent molar volumes and isentropic compressibility values in dilute region were acquired through fitting density and speed of sound data to Redlich-Mayer equation and the viscosity B and D coefficients values were given by Jones-Dole equation.