Volumetric, acoustic and viscometric investigation of ceftriaxone disodium in aqueous solutions of 1-propanol and 2-propanol

Abstract

The extraction and purification of ceftriaxone disodium from aqueous solution carried out with organic solvents. Therefore volumetric, acoustic and viscometric properties of ceftriaxone disodium in aqueous solutions of 1–propanol and 2–propanol were investigated at T/K = (288.15–308.15). The apparent molar volumes and isentropic compressibility values in dilute region were fitted to Redlich-Mayer equation. The infinite dilution apparent molar transfer volumes, ΔtrVφo, were often negative and increased with increasing the concentration of 1–propanol and 2–propanol. This behaviour reveals that there are strong ionic-polar interactions between ions of CFNa and 1–propanol or 2–propanol with respect to water; because the polarizability of 1–propanol and 2–propanol is greater than those of water. The apparent molar isentropic compressibility at infinite dilution, κφo, of CFNa in the aqueous solutions of 1–propanol and 2–propanol are higher than those of pure water. Therefore the CFNa was dehydrated with addition of 1–propanol or 2–propanol. To obtain viscosity B and D coefficients, the viscosities data were fitted to the Jones-Dole equation. The viscosity B-coefficient of CFNa in the aqueous solutions of 1–propanol and 2–propanol was lower than those of CFNa pure water. Therefore it can be concluded that CFNa solvated in water rather than the aqueous solutions of 1–propanol and 2–propanol.