Molecular interactions of drug semicarbazide hydrochloride in aqueous-D-xylose/L-arabinose solutions at different temperatures: Volumetric, acoustic and viscometric study

Abstract

The interactions of drug semicarbazide hydrochloride in water and in aqueous-carbohydrate (D-xylose/L-arabinose) solutions from their physicochemical behaviour are studied. Density, ρ, ultrasonic speed, u and viscosity, η of the drug semicarbazide hydrochloride in water and in aqueous-D-xylose/L-arabinose (5 wt% and 10 wt% of D-xylose/L-arabinose in water, w/w) solvents were measured as functions of concentrations at temperatures, T = (293.15 – 318.15) K and at atmospheric pressure, p = 101 kPa. The measured data have been utilized to calculate various properties like the apparent molar volume, Vφ from density measurements while apparent molar compressibility, Ks,ϕ, acoustic impedance, Z and intermolecular free length, Lf from ultrasonic speed measurements. The values obtained from these parameters indicate strong solute–solvent interactions within the solutions. The viscosity data have been analyzed using Jones-Dole equation and coefficients A and B were evaluated. The temperature derivative of B-coefficient, dB/dT together with activation parameters of viscous flow have also been determined. The results are discussed in terms of hydrophilic-hydrophilic and hydrophilic-hydrophobic interactions in these systems along with the structure breaking/making ability of the drug.