This special issue of IEEE Transactions on Circuits and Systems—Part II: Express Briefs (TCAS-II) represents a new co-publication initiative of the IEEE Circuits and Systems Society (CASS) to publish a selection of the best papers accepted for presentation at the IEEE International Symposium on Circuits and Systems (ISCAS), held in Florence, Italy, on May 27–30, 2018. As TCAS-II only publishes 5-page briefs, and hence both conference and journal (revised) versions of these works would largely overlap, the papers included in this issue that you are holding represent the only record published in IEEE Xplore and they will not appear in Proceedings of IEEE International Symposium on Circuits and Systems (ISCAS) , which will however contain DOI links to the corresponding TCAS-II papers. With this initiative, CASS joins other forward-looking IEEE Societies, namely, the IEEE Robotics and Automation Society and IEEE Control Systems Society, which have developed a similar process for presenting papers submitted to the IEEE Robotics and Automation Letters or to the IEEE Control Systems Letters at ICRA, CASE, or IROS and to CDC, respectively. In a world where the role of a conference is shifting more and more to a networking event and a scientific discussion opportunity, and in which the importance of conference publications is vanishing (except for some specific fields), we consider this opportunity an important step forward for the CASS community.