High-level Talents Research Articles

LncRNA MEG3 Alleviates Cognitive Impairments by Reducing Mitochondrial-Derived Apoptosis Through Promoting FUNDC1-Related Mitophagy <i>via</i> Rac1-ROS Axis

Background: Mitochondrial dysfunction and elevated ROS generation are predominant contributors of neuronal death that is responsible for the diabetes-related cognitive impairments. Emerging evidence demonstrated that long non-coding RNA-MEG3 can serve as an important regulator in the pathogenesis of diabetes. However, the underlying mechanisms need to be further clarified. Methods:The molecular biological effects and cellular approaches of MEG3 on STZ -induced diabetic rats and high glucose treated PC12 cells were assessed in vitro and in vivo. Findings:Here, it was observed that MEG3 was significantly down-regulated in STZ (streptozotocin)-induced diabetic rats. MEG3 overexpression notably improved diabetes-induced cognitive dysfunctions, accompanied by the abatement of Rac1 activation and ROS production, as well as the inhibition of mitochondria-associated apoptosis. Furthermore, either MEG3 overexpression or Rac1 inhibition promoted FUNDC1 dephosphorylation and suppressed oxidative stress and neuro-inflammation. Similarly, in vitro studies confirmed that hyperglycemia also down-regulated MEG3 expression in PC12 cells. MEG3 reintroduction protected PC12 cells against hyperglycemia-triggered neurotoxicity by improving mitochondrial fitness and repressing mitochondria-mediated apoptosis. Moreover, these neuroprotective effects of MEG3 were relied on FUNDC1-related mitophagy, since silencing of FUNDC1 abolished these beneficial outcomes. Additionally, MEG3 rescued HG-induced neurotoxicity was involved in inhibiting Rac1 expression via interacting with Rac1 3’UTR. Conversely, knockdown of MEG3 showed opposite effects. NSC23766, a specific inhibitor of Rac1, fully abolished harmful effects of MEG3 depletion. Identically, knockdown of Rac1 potentiated FUNDC1-associated mitophagy. Meanwhile, co-localization of Rac1 and FUNDC1 was found in mitochondria under hyperglycemia, which was interrupted by MEG3 overexpression. Furthermore, silencing of Rac1 promoted PGAM5 expression, and FUNDC1 strongly interacted with LC3 in Rac1-deleted cells. Interpretation: Altogether, our findings suggested that Rac1/ROS axis could be a downstream signaling pathway for MEG3-induced neuroprotection, which was involved in FUNDC1-associated mitophagy. Funding Statement: This work was supported by the National Natural Science Foundation of China (grant numbers 81771422), Hunan Provincial Natural Science Foundation (grant numbers 2019JJ50931) and Basic and Applied Basic Research Program & High-level Talents Project of Hainan Province of China (grant numbers 2019RC365). Declaration of Interests: The authors declared that they have no conflicts of interest. Ethics Approval Statement: All animal experiments were approved by the Ethics Committee of Xiangya Hospital of Central South University (2017-03346), and every effort was made to minimize the number and suffering of animals.

Global Incidence and Prevalence of Bullous Pemphigoid: A Systematic Review and Meta-Analysis

Background: Bullous pemphigoid (BP) is the most common autoimmune blistering disease. Although there have been some studies on the epidemiology of BP in different regions, global estimates of the incidence and prevalence of BP are still lacking. Methods: A systematic review of population-based studies as well as outpatient and inpatient studies reporting the incidence and (or) prevalence of BP was performed. The Medline, EMBASE and Cochrane Library databases were searched from their inception to September 1, 2019. Quantitative studies investigating the incidence and prevalence of BP were included. Quality assessment was performed with a tool designed to provide a critical appraisal of prevalence or incidence studies. We investigated the incidence and prevalence of BP stratified by continent, age, sex and diagnostic method. Between-study heterogeneity was assessed using the I2 statistic. Findings: In the 35 included studies, 143,005,387 individuals from 23 countries were examined; 22 (62.9%) studies from 17 countries reported the incidence (n=51,849,277) and 15 studies from 14 countries (42·9%) reported the prevalence (n= 93,895,512). Two (5·7%) studies mentioned both the incidence and the prevalence. We found that the overall incidence of BP was 0·1138 per 10,000 person-years (95% CI: 0·0631–0·1341). the specific prevalence values were 0·2397 (95% CI: 0·1972-0·2849), 0·1444 (95% CI: 0·0879-0·2122), 0·082 (95% CI: 0·0197-0·1814) and 0·0342 (95% CI: 0·0254-0·0443) per 10,000 person-years in North America, Europe, Asia, and Africa, respectively; the incidence values for males and females were 0·0172 (95% CI: 0·0075-0·0396) and 0·01334 (95% CI: 0·0048-0·0221) per 10,000 person-years, respectively; and the incidence values among the age groups of 80+, 70-79 and 60-69 years old were 0·1913 (95% CI: 0·0811-0·3344), 0·1154 (95% CI: 0·0894-0·1443) and 0·0313 (95% CI: 0·02-0·0449) per 10,000 person-years, respectively. With regard to the different diagnostic methods, the incidence values were 0·1610 (95% CI: 0·0666-0·2863), 0·091 (95% CI: 0·0122-0·2318), 0·0540 (95% CI: 0·0041-0·1552), and 0·0471 (95% CI: 0·0094-0·1113) per 10,000 person-years for “typical clinical features + histopathology + direct immunofluorescence + serological test”, “typical clinical features + direct immunofluorescence + serological test”, “typical clinical features + serological test” and “typical clinical features + histopathology + serological test”, respectively. For the population-based prevalence, the pooled value was 0·02% (95% CI: 0·001-0·19). For the clinic-based prevalence, the pooled value was 0·11% (95% CI: 0·03-0·43). Interpretation: This study estimated the global incidence and prevalence of BP with respect to its spatial and population distributions. The overall estimate of the pooled incidence of BP was 0·1138 per 10,000 person-years. A higher incidence of BP was found in North America, among females and among older people. The pooled population-based and clinic-based prevalence estimates were 0·02% and 0·11%, respectively. The findings should be cautiously interpreted due to the high degree of heterogeneity among the included studies. Funding Statement: The First-class Discipline Construction Foundation of Guangzhou University of Chinese Medicine (Chinese medicine department), the Young Top Talent Project of Scientific and Technological Innovation in Special Support Plan for Training High-level Talents in Guangdong (No. 2017TQ04R627) and the Youth Research and Cultivation Project of Guangzhou University of Chinese Medicine (No. 2019QNPY02). Declaration of Interests: The authors declare that they have no conflicts of interest. Ethics Approval Statement: PRISMA was utilized for this study.

Effects of Conservative Versus Liberal Oxygen Therapy on the Outcomes of Critically Ill Patients: A Systematic Review and Meta-Analysis

Background: The liberal use of supplemental oxygen therapy is common in intensive care units (ICUs) for critically ill patients, but this practice still lacks high-quality evidence, especially for patients receiving mechanical ventilation (MV). We systematically reviewed the effects of conservative versus liberal oxygen therapy in critically ill adults. Methods: We searched the following electronic databases, including dates from Jan 1st, 2001 until Nov 31st, 2018: PubMed/MEDLINE, Embase, the Cochrane (Central) database and Ovid. Randomized controlled clinical trials (RCT), before-and-after trials or cohort studies comparing conservative with liberal oxygen therapy in critically ill adults (aged ≥18 years) were retrieved. The main outcomes were mortality and ventilator-free days, length of stay, and adverse effects assessed by random-effects meta-analyses. We used the GRADEpro Guideline Development Tool and Trial sequential analysis (TSA) to evaluate the quality of evidence and information size, respectively. Meta-regression was conducted to explore heterogeneity among studies. Findings: Five RCTs and 2 before-and-after trials enrolled 16188 ICU patients. Compared with liberal oxygen therapy, a conservative oxygen strategy (maintaining peripheral oxygen [SpO2] ≤ 98% or arterial oxygen partial pressure [PaO2] ≤ 100 mmHg at the lowest possible FiO2) decreased hospital mortality (RR = 0.88; 95% CI, 0.81-0.95; p = 0.002, moderate quality), especially for patients receiving MV (N = 12327; RR = 0.91; 95% CI, 0.84-1.00; p = 0.05, moderate quality). Moreover, it reduced hospital length of stay (Std. MD = -0.04; 95% CI, -0.06- -0.01; p = 0.01, moderate quality) and increased ventilator-free days either at day 28 (Std. MD = 0.04; 95% CI, 0.01-0.08; p = 0.005, low quality) or during ICU stay (Std. MD = 0.49; 95% CI, 0.30-0.68; p < 0.00001, low quality). The incidence of new bacteremia was much lower in the conservative oxygen therapy group (RR = 0.53; 95% CI, 0.30-0.92; p = 0.02, very low quality). TSA indicated that no more clinical studies should be conducted to prove a beneficial effect of conservative oxygen therapy on hospital length of stay rather than ICU length of stay for critically ill patients. Interpretation: In critically ill adults, conservative oxygen therapy improves hospital mortality, decreases hospital length of stay and increases ventilator-free days, without impacting overall adverse effects. More clinical trials with better designs are needed to optimize the strategy of conservative oxygen therapy in ICU. Funding Statement: This work was supported by the National Natural Science Foundations of China (No. 81571874, 81670074, 81870066), the Key Research and Development Plan of Jiangsu Province (BE2018743), the Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX17_0168), Natural Science Foundation of Jiangsu Province (BK20171271), the Jiangsu Provincial Medical Youth Talent (QNRC2016807) and Third Level Talents of the “333 High Level Talents Training Project” in the fifth phase in Jiangsu (LGY2016051). Declaration of Interests: None declared.

Increased Plasma Dipeptidyl Peptidase-4 Activities Predict Mild Cognitive Impairment in Elderly Type 2 Diabetic Patients: Findings from the GDMD Cohort Study in China

Background: Dipeptidyl peptidase-4(DPP4) is a newly identified adipokine that has been proved to promote hyperglycemia, insulin resistance, oxidative stress and inflammation, all of which have been involved in the pathogenesis of mild cognitive impairment (MCI). Hence, we examined whether increased DPP4 activity was associated with prospective risk of MCI and determined whether this association was mediated by these four risk factors in elderly type 2 diabetic patients. Methods: Baseline plasma DPP4 activity, HOMA of insulin resistance (HOMA-IR), oxidative stress parameters, inflammatory markers and long-term glycemic control were ascertained in a cohort of elderly type 2 diabetic patients aged>60 years (n = 2,066), along with questionnaire findings, biochemical measurements and MCI diagnoses. Prospective associations of baseline DPP4 activity and MCI events and its possible mediators were determined by Cox regression and mediation analyses. Findings: Over a median follow-up of 4.8 years, 367 patients (17.8 %) were diagnosed with MCI. Higher baseline DPP4 activity, IL-6, CRP, nitrotyrosine and 8-iso-PGF2a were independent predictors of MCI after adjustment (P<0.001). Furthermore, IL-6, CRP, nitrotyrosine and 8-iso-PGF2a all had statistically significant mediating effects on DPP4 activity-associated MCI incidence (P<0.05). We did not find a positive association between baseline HOMA-IR, average HbA1c and MCI incidence. Interpretation: Our results suggest that increased plasma DPP4 activity is an independent risk factor for incident MCI, and this association appears to be partially mediated by oxidative stress and inflammation, not insulin resistance or long-term glycemic control, both of which might not be able to predict MCI as well. Trial Registration: Registered on the Chinese clinical trial registry (ChiCTR-EPC-14005273). Funding Statement: This study was supported by grants from National Natural Science Foundation of China (Grant NO. 81770829 and NO. 81560144), Scientific Research and Technology Development Projects of Science and Technology Department of Guangxi province (Grant NO.1598012-13), Natural Science Foundation of Guangxi Province (Grant NO. 2015GXNSFBA139119) and High-Level Medical Talents Training Program of Guangxi Province (G201903002). Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: The GDMD Study was approved by the institutional medical ethical committee at Affiliated Hospital of Guilin Medical University. All participants gave written informed consent before data collection.

Tetraalkyl-substituted zinc phthalocyanines used as anode buffer layers for organic light-emitting diodes**Project supported by the Shenzhen Personal Maker Project, China (Grant No. GRCK2017082316173208), the Shenzhen Overseas High-level Talents Innovation Plan of Technical Innovation, China (Grant No. KQJSCX20180323140712012), and the Special Funds for the Development of Strategic Emerging Industries in Shenzhen, China (Grant No. JCJY20170818154457845).

Two soluble tetraalkyl-substituted zinc phthalocyanines (ZnPcs) for use as anode buffer layer materials in tris(8-hydroxyquinoline)aluminum (Alq3)-based organic light-emitting diodes (OLEDs) are presented in this work. The hole-blocking properties of these ZnPc layers slowed the hole injection process into the Alq3 emissive layer greatly and thus reduced the production of unstable cationic Alq3 () species. This led to the enhanced brightness and efficiency when compared with the corresponding properties of OLEDs based on the popular poly-(3, 4-ethylenedioxythiophene): poly(styrene sulfonate) (PEDOT: PSS) buffer layer. Furthermore, because of the high thermal and chemical stabilities of these ZnPcs, a nonaqueous film fabrication process was realized together with improved charge balance in the OLEDs and enhanced OLED lifetimes.

Practice and Thoughts on Cultivation of Graduate Students Majoring in Engineering Management

The professional master degree of engineering management in military schools in the new era aims to cultivate high-level and application-oriented graduate talents who understand technology and have the superior comprehensive capacity of management, command, coordination and decision-making ability. The combination of scientific research innovation and military engineering management practice is highlighted. In the meanwhile, it emphasizes the integration of engineering technology and military drill implementation, and it pays much attention to the compound concept. Research and practice are carried out from the aspects of training objectives, training programs, curriculum system, teaching implementation, process control. In order to improve the training quality of engineering management graduate students, the characteristics of experience and considered the existing problems are summarized.

122O - Should transarterial chemoembolization be continued after non-response to the first two sessions for intermediate-stage hepatocellular carcinoma?

BackgroundCurrent guidelines recommend that two transarterial chemoembolization (TACE) should be performed before switching to another treatment for intermediate-stage HCC, but without robust evidence. Considering the paucity of effective subsequent treatments after TACE-refractoriness, we aimed to evaluate radiologic response of HCC to the third TACE (TACE-3) after nonresponse (stable disease (SD) or progressive disease (PD)) to the first two sessions, and to establish a nomogram to predict responders to TACE-3. MethodsThe study enrolled 1672 intermediate-stage HCC patients with Child-pugh A liver function (training cohort: n = 918; internal validation cohort: n = 460; external validation cohort: n = 294) who did not respond to (based on mRECIST) the first two TACE but underwent ≥3 consecutive TACE from three centers. Radiologic response rate to TACE-3 and its correlation with overall survival (OS) was evaluated. Nomogram predicting responders to TACE-3 was established and validated. ResultsFor patients with SD after the first two TACE, the response rate after TACE-3 was 44.4% in training and internal validation cohorts and 51.5% in external validation cohort. For patients with PD, corresponding rates were 2.7% and 2.2%. Responders to TACE-3 achieved higher 5-year OS rates than non-responders in three cohorts (all P < 0.001). Radiologic response to TACE-3 (HR = 0.151, 95% CI: 0.117-0.195, P < 0.001) was the strongest prognostic factor of OS. The C-index of nomogram, constructed by tumor size, tumor capsule and alpha-fetoprotein, was 0.835 (95% CI: 0.810, 0.861) in training cohort, 0.853 (95% CI: 0.819, 0.887) in internal validation cohort and 0.846 (95% CI: 0.825, 0.892) in external validation cohort. ConclusionsApproximately 50% of patients with SD could respond to TACE-3 with improved survival whereas patients with PD barely could. Our nomogram is effective in predicting responders to TACE-3. Legal entity responsible for the studyThe First Affiliated Hospital of Sun Yat-sen University. FundingThe National Natural Science Foundation of China (No. 81801703), the Guangdong Natural Science Foundation of Guangdong Province (No. 2018A030310282), the National high level talents special support plan--“Ten thousand plan"--Young top-notch talent support program, the National Science Fund for Distinguished Young Scholars (No. 81825013). DisclosureAll authors have declared no conflicts of interest.

1919P - FGF19 promotes esophageal squamous cell carcinoma progression by inhibiting autophagy

BackgroundEsophageal squamous cell carcinoma (ESCC) with high mortality is particularly prevalent in China and the prognosis is poor. Although genetic amplification and overexpression of the fibroblast growth factor 19 (FGF19) gene are found in ESCC, mechanisms that contribute to such functional alterations remain elusive. MethodsGene-Panel Sequencing was used to detect genetic variants that may be associated with a risk of ESCC. The effect of proliferation inhibition of LY2874455, which is inhibitor of fibroblast growth factor receptors (FGFR), was assessed in ESCC patient-derived cell (PDC) and xenograft (PDX) models. Autophagic activity was evaluated by immunoblotting for microtubule-associated protein 1 light chain 3 (LC3) and p62. ResultsUsing Gene-Panel Sequencing of 161 FFPE tissues, we found that FGF19 copy number amplified in almost 30% ESCC. Pharmacological of FGF19/FGFR by LY2874455 significantly induces repression of FGF19 amplificated ESCC progression in either PDC or PDX models. Mechanistic study revealed that treatment with LY2874455 induced activity of autophagy by inhibiting the ERK/MAPK pathway not by AKT pathway. ConclusionsOur findings reveal that FGF19 amplification inhibits autophagic activity by increasing the phosphorylation level of ERK, which may play an essential role in the pathogenesis of ESCC. Using FGFR inhibitor may represent an effective strategy to suppress FGF19 amplificated ESCC development and progression. Legal entity responsible for the studyThe authors. FundingThe Major Project of Health Commission of Zhejiang Province of China (No. WKJ-ZJ-1902), the Public Welfare Technology Foundation of Zhejiang Province of China (No. 2017C34001), Zhejiang high-level innovative talent program, and the 1022 program of Zhejiang Cancer Hospital. DisclosureAll authors have declared no conflicts of interest.

Research on Talent Ecosystem of High-end Equipment Manufacturing Industry in Zhenjiang High-tech Zone

Aiming at the talent ecosystem of high-end equipment manufacturing industry in Zhenjiang High-tech Zone, studies the mechanism and law of interaction between talent and talent environment from the perspective of ecology. Applies the theory of talent ecosystem to the practice of talent development in high-tech zone, establishes the talent ecosystem of high-end equipment industry in Zhenjiang High-tech Zone from the perspective of ecology, finds and solves the problem of high-tech. The problems existing in the talent system in the region provide new solutions for the construction of high-level talent system in high-tech zones, provide talent support and intellectual support for the promotion of high-quality development in Zhenjiang.

Effect of health alliances on the quality of primary care in urban China: a coarsened exact matching difference-in-differences analysis

BackgroundTo improve the quality of primary care and guide patients flowing to primary facilities, the Chinese Government called for piloting of health alliances—associations led by tertiary hospitals and composed of primary and secondary hospitals within a catchment area. We assessed the effects of health alliances, and compared loose versus tight health alliances, with respect to improving the quality of primary care provided through community health centres in urban China. MethodsTrained simulated patients presented to community health centres in Xi'an with one of two common outpatient diseases (unstable angina or asthma). Data from recorded patient–physician interactions were used to assess quality of primary care with respect to adherence to clinical checklists, accuracy of diagnoses, and appropriateness of treatment (each graded against checklists of recommended questions, examinations, diagnoses, and treatments), as well as proportions of unnecessary examinations and of harmful prescriptions, diagnosis and waiting times, and patient-centred communication scores (9-item Patient Perception of Patient-Centeredness scale). Difference-in-difference analyses combined with a coarsened exact matching method were used to identify the direct causal effects of health alliances and their various modes on primary care quality over time, after controlling for patient gender, physician gender, physician age, and health centre characteristics, as well as the fixed effects of disease, district, health centre, and survey time. FindingsBetween Aug 17 and Aug 28, 2017, and July 30 and Aug 10, 2018, eight simulated patients completed 484 interactions with physicians across 63 community health centres. Centres included in health alliances, compared with those not included, saw improvements in adherence to clinical checklists (0·36 percentage points increase, p<0·0001), correct treatments (4·18 percentage points increase, p=0·0020), proportions of interactions involving unnecessary examinations (0·81 percentage points decrease, p<0·0001) or harmful drug prescriptions (2·67 percentage points decrease, p=0·0360), and patient-centred communication scores (0·80-point increase, p<0·0001); whereas diagnosis times increased by 4·03 min (p<0·0001), and waiting times (1·11 min decrease, p=0·7910) and correct diagnoses (0·19 percentage points decrease, p=0·8650) were similar. Compared with loose health alliances, tight health alliances saw significantly improved adherence to clinical checklists (1·35 percentage points increase, p<0·0001) and correct diagnoses (0·61 percentage points increase, p<0·0001), decreased proportions of unnecessary examinations (1·65 percentage points decrease, p=0·0440), increased diagnosis times (0·36 min increase, p=0·0470), and improved patient-centred communication (1·35-point increase, p<0·0001), while other quality aspects were similar. InterpretationHealth alliances can improve the quality of some aspects of primary care by helping to sink the high-quality health resources of tertiary hospitals and secondary hospitals to primary health facilities. Tight health alliances are more likely to improve the quality of primary care, probably because of the increased collaboration between primary care facilities and larger hospitals and the unification of human resources, finances, and materials. FundingChina Medical Board (grant number 15-277), National Natural Science Foundation of China (grant number 71874137), Shaanxi Social Science Foundation (grant number 2017S024), Research Program of Shaanxi Soft Science (grant number 2015KRM117), National High-Level Talents Special Support Plan (Thousands of People plan), Shaanxi Provincial Youth Star of Science and Technology in 2016.

Compact finite difference schemes for the backward fractional Feynman–Kac equation with fractional substantial derivative**Project supported by the National Natural Science Foundation of China (Grant No. 11471262) and Henan University of Technology High-level Talents Fund, China (Grant No. 2018BS039).

The fractional Feynman–Kac equations describe the distributions of functionals of non-Brownian motion, or anomalous diffusion, including two types called the forward and backward fractional Feynman–Kac equations, where the non-local time–space coupled fractional substantial derivative is involved. This paper focuses on the more widely used backward version. Based on the newly proposed approximation operators for fractional substantial derivative, we establish compact finite difference schemes for the backward fractional Feynman–Kac equation. The proposed difference schemes have the q-th (q = 1,2,3,4) order accuracy in temporal direction and fourth order accuracy in spatial direction, respectively. The numerical stability and convergence in the maximum norm are proved for the first order time discretization scheme by the discrete energy method, where an inner product in complex space is introduced. Finally, extensive numerical experiments are carried out to verify the availability and superiority of the algorithms. Also, simulations of the backward fractional Feynman–Kac equation with Dirac delta function as the initial condition are performed to further confirm the effectiveness of the proposed methods.

Discussion on the Building of Master's Practice Base of Architecture and Civil Engineering

Professional Master is a practice-oriented, practice-based support to cultivate high-level application-oriented talents with solid theoretical basis to adapt to the development of enterprises. In this paper, the ways that building of Master's Practice Base for Architecture and Civil Engineering Major were discussed, the ways include building practice base on university's own, university cooperating with enterprise in building practice base and university utilizing enterprise practice base. This paper would provide new ideas for improving the practical ability of Master's Major in Architecture and Civil Engineering.

Inquiry Based Teaching in an Animation Multimedia Course

In the process of cultivating high-level animation talents, high-quality animation course can play a crucial role, and effectively improve design and innovation ability. However, current animation course design and teaching also have obvious defects. The inquiry teaching of subject activity can play a positive role in training students’ innovation and creation ability and thus effectively make up for the shortcomings in animation course teaching. In this study, animation multimedia course was taken for example to explore the design and teaching application practice of maker education method based on “activity inquiry”. The maker teaching mode based on “activity inquiry” comprises four modules: teaching process, teaching objective, teaching design, and analysis of students’ performance. On this basis, it was applied in the teaching practice of animation multimedia course. Besides, the decision tree algorithm was innovatively adopted in this experiment to analyze students’ performance, and decision-making tree analytical framework for students’ performance was constructed, including data acquisition, data preprocessing, data classification &amp; mining, and classification rule generation. Finally, the teaching test results indicate that the proposed teaching mode can significantly improve teaching effect, and actively promote students’ core ability training in terms of animation design and creation.

An Analysis on Influence Factors and Their Relative Structure of HIDZs’ Innovation Driven Development Based on Project Management Theory

Fourteen main influence factors of HIDZs’ innovation driven development are refined from existing literature published, through applying bibliometrics methods and meta analysis. After that, the relative structure of fourteen main influence factors are studied by using interpretive structural model. The research results show that HIDZs’ innovation driven development is directly influenced by product combination line, product value chain reconstruction, penetration of new business, high level talent introduction, human capital investment, expansion of new markets and discovery of new profit centers; It can be indirectly affected by existing technology integration innovation, industrial structure innovation, industry sector innovation, new product development, new market mechanism; new technology R&D and application of high and new technology can play a fundamental influence role to innovation driven development.

Charge trapping memory device based on the Ga2O3 films as trapping and blocking layer* *Project supported by the National Natural Science Foundation of China (Grant Nos. 61674050 and 61874158), the Top-notch Youth Project in Hebei Province, China (Grant No. BJ2014008), the Outstanding Youth Project of Hebei Province, China (Grant No. F2016201220), the Outstanding Youth Cultivation Project of Hebei University, China

We present a new charge trapping memory (CTM) device with the Au/Ga2O3/SiO2/Si structure, which is fabricated by using the magnetron sputtering, high-temperature annealing, and vacuum evaporation techniques. Transmission electron microscopy diagrams show that the thickness of the SiO2 tunneling layer can be controlled by the annealing temperature. When the devices are annealed at 760 °C, the measured C–V hysteresis curves exhibit a maximum 6 V memory window under a ±13 V sweeping voltage. In addition, a slight degradation of the device voltage and capacitance indicates the robust retention properties of flat-band voltage and high/low state capacitance. These distinctive advantages are attributed to oxygen vacancies and inter-diffusion layers, which play a critical role in the charge trapping process.

Analysis of Competitive Situation in Basic Research of Global Intelligent Robots

Practically grasp the global development trend of the basic research on intelligent robots and provide support for the scientific development of intelligent robots in China. Relying on bibliometrics, this paper has proposed a four-dimensional competitive situation analysis system for basic research based on activeness and talent distribution, etc., which can effectively analyze the global situation of basic research on intelligent robots, able to reveal and describe the competition status quo and situation of the basic scientific research in specific fields. There is a big gap between China and the United States in basic research on intelligent robots, mainly including such aspects as follows: uneven distribution of high-level basic research talents; insufficient international cooperation in high-level scientific research; lower research activeness; layout of key research and development.

Research on the Database of Competitive Sports Talents in Colleges and Universities in China under the Background of “Internet+”

In order to promote the rapid development of competitive sports in colleges and universities in China, the database of talent cultivation is constructed by using Internet technology so as to provide high-level sports talent for colleges and universities. Using field investigation and logical analysis to construct the base of training database of competitive sports talents in colleges and universities under the background of “Internet+” situation and feasibility of scientific cloud computing analysis and the construction of a database, this paper is intended to provide a variety of valuable information and data for the training of competitive sports talents in colleges and universities, to enhance the quality and level of competitive sports talents in colleges and universities.

Co-Administration of Aspirin and L-DOPA Against 6-OHDA-Induced Dopamine Neurotoxicity

Background: At present, L-DOPA remained the gold standard therapy for motor symptoms of Parkinson's disease (PD) patients. However, prolonged administration of L-DOPA led to the development of dyskinesia. Aspirin, a non-steroidal anti-inflammatory drug (NSAID), has been widely used to relieve pain and inflammation. Recent studies indicated that aspirin produced neuroprotection against DA neuronal loss in PD animal model. Methods: Rats lesioned with 6-hydroxydopamine (6-OHDA) in substantia nigra were employed and treated with L-DOPA and aspirin for 21 days. The movement disorders elicited by L-DOPA were determined by the abnormal involuntary movements (AIM) scores analysis. Finding: In 6-OHDA lesioned rat PD model, aspirin or L-DOPA evoked DA neuroprotection 7 days after treatment. Co-administration of aspirin and L-DOPA still conferred neuroprotection. In addition, aspirin attenuated the development of LID, as evidenced by the decreased AIM scores without interfering with L-DOPA efficacy 21 days after treatment. Furthermore, aspirin combined with L-DOPA inhibited microglia and astroglia activation and the subsequent neuroinflammatory responses. Importantly, aspirin didn't produce side effects during this neuroprotection. Interpretation: These results suggest that aspirin might have beneficial potential to attenuate L-DOPA efficacy and alleviate LID in PD. Funding Statement: National Natural Science Foundation of China (No. 81760658), foundation for High-level Innovative Talents of Guizhou Province (No. 20164027), Shijingshan's Tutor Studio of Pharmacology (No. GZS-201607), Innovation Research Group project of Education Department of Guizhou Province (No. 2016038), foundation for Excellent Young Talents of Zunyi Medical University (No.201603). Declaration of Interests: The authors have declared no any conflict of interests. Ethics Approval Statement: All animal experiments were performed in accordance with Chinese Guidelines of Animal Care and Welfare, and the present study was approved by the Animal Care and Use Committee of Zunyi Medical University (Zunyi, China).

Research and development of mAb drugs in China: a look from policy perspectives

ABSTRACTBackground: Monoclonal antibody (mAb) drugs are increasingly important for the pharmaceutical industry across the globe. In China, mAb drug developments face many challenges. Multiple policies have been implemented recently to reinforce support in various areas. This study aims to investigate the latest landscape of mAb drugs in China from policy perspectives encompassing R&D, clinical trials, marketing approval, and talent pools.Methods: Information about mAb drugs approved in the United States, the European Union, Japan, and China by 2017 and mAb-related policies in China were retrieved from government websites and third-party statistical databases for descriptive, statistical, and comparative analysis.Results and discussion: In China, 21 mAb drugs (10 locally-developed and 11 imported) have so far been approved. For the 11 imported mAb drugs in China, the median drug lag in the marketing approval was estimated at 87.1 months, compared with the U.S. (0 months), the EU (8.9 months), and Japan (43.4 months). However, as far as the dramatically changing innovation supporting system in China is concerned, emergence of new biopharmaceutical companies, transformation of the current drug companies and their shift to antibody therapy, and the pooling of high-level talent contribute to mAb development in China. The number of clinical trials and marketing applications and approvals involving mAb drugs is also growing. Favorable policies will continue to play a role in the sustainable development of mAb drugs in China.Conclusion: The research showed that the reform of multiple policies and incentives for attracting/retaining high-level talent has evidently been effective in addressing the drug lag of mAb drugs in China. In future development, China should actively monitor the global R&D outcomes and industrial development trends of mAb drugs and make the policy environment more attractive to enable more mAb drugs to be marketed in China as soon as possible.

Development of High-level Talents Lecturer Team in Provincial Universities: Study on Tongren University, Guizhou, China

The critical period of China’s advanced education change, nearby common commonplace schools and colleges have changed from connected gifts to connected abilities, and schools have progressed to applied technology universities. The study at hand has been developed following a quantitative research method and tries to attain further understanding. Henceforth, the required primary data were collected by following a survey strategy by giving out self-administered questionnaires. Full-time teachers engaged in teaching at Tongren University in Guizhou, China were selected as the sampling frame for this study. The study showed that the Policy (POL) has a positive impact on Improving the Sustainable Development of Lecturers (SPD). The results of the study are given to the status quo of the construction of the lecturer team, the optimisation of the policy, and the average score of the sustainable development of the lecturer team with different professional qualifications and different levels of education. Colleges and universities must achieve self-use within the total number of approved preparations, position self-determination, high-level professional titles account for a higher proportion of job placement, self-determination of employment conditions, and independent employment of high-level talents. This study is limited to Tongren University and may not provide similar findings in a different university. However, this study can be used as a guideline for future study on other factors which will influence the development of high-level talent lecturer team. Keywords : High-level Talents Lecturer Team, Tongren University Guizhou, China DOI : 10.7176/EJBM/11-14-02 Publication date :May 31 st 2019