High-level Talents Research Articles

How to manage the personnel files of high-level personnel well in Chinese universities

To further play the role of personnel file in high-level talent management, boost high-level talents in Chinese colleges and universities should play value, development of this research by several universities high-level talents for China's henan province personnel file management present situation analysis, from high-level personnel personnel file management research to individuation, combined with the survey data, literature review and related policies, This paper puts forward effective countermeasures and suggestions on how to make rational use of high-level talents with the help of personalized construction of personnel files of high-level talents in Chinese universities.

Research on the Current Situation of China's High-level Talents Introduction Policy

The introduction of high-level talents is currently the main means of acquiring talents and enhancing competitiveness in various regions. The formulation of talent introduction policies will have a profound impact on the introduction and long-term development of talents. At present, my country's high-level talent introduction policies show convergence, and there are certain problems in the introduction of subjects, introduction models, etc., to conduct in-depth research on this and put forward countermeasures and suggestions to improve my country's high-level talent introduction policies.

The Establishment and Exploration of Diversified High Level Engineering Practice Education Platform

Practical teaching is not only an important link in the process of cultivating applied talents, but also an important means to improve students' engineering application ability and innovation ability. In order to cultivate high-level application-oriented talents, aiming at the current lack of digital and intelligent knowledge among college students and the lack of "personalized" specialty, this research group adheres to engineering practice education as the main line, aims at cultivating application-oriented talents in engineering, and features in improving students' innovation ability. With the construction of new curriculum system, new innovation and entrepreneurship system and new practical teaching system as the core, it has built a diversified high-level engineering education practice platform integrating digital analysis and simulation, intelligent manufacturing and testing, and virtual simulation of production process. Explore its own distinctive characteristics of high-level application-oriented talent training new mode and new ways, cultivate students' innovative thinking and the ability to solve practical problems, in mechanical design ability has been rapidly improved, become an expert in design. At the same time, the level of intelligent manufacturing and intelligent detection has been improved, and personalized high-end talents with both professional knowledge and digital and intelligent knowledge have been refined to meet the social demand for such technical compound talents.

Potential Targets of Nitidine Chloride in Wilms Tumour Revealed by Network Pharmacology, RNA-Seq and Microarrays

Background: Wilms tumour is the most common childhood renal cancer that requires development of better treatments. Nitidine chloride, a Chinese traditional medicine, could have therapeutic potential for Wilms tumour, however there have been no studies to date. Methods: In-house RNA-seq was performed and public RNA-seq plus microarrays datasets were incorporated for identifying the landscape of differentially expressed genes (DEGs) in Wilms tumour. Meanwhile, the potential targets of nitidine chloride in Wilms tumour were acquired through combined analysis of computational prediction and DEG, which was further validated by molecular docking. The molecular mechanism of nitidine chloride-putative targets was investigated through transcription factors and gene set enrichment analysis. Findings: As a result, a total of 1819 upregulated DEGs and 1942 downregulated DEGs were identified in Wilms tumour. Twenty-three putative targets of nitidine chloride in Wilms tumour were determined and nine showed strong binding force with nitidine chloride in molecular docking. IMPDH2 and MAP4K4 exhibited significant value of prognostic signification. The upregulation of these putative targets in Wilms tumour may be induced by transcription factors (TFs) such as MYC, E2F1, SOX2, MYCN, MITF and CREM. The hub putative targets of nitidine chloride in Wilms tumour were enriched in pathways such as cell cycle, chemokine signaling pathway, glycolysis and gluconeogenesis. Interpretation: In conclusion, the putative pharmacologic targets and molecular pathways of nitidine chloride in Wilms tumour were unveiled in this study. Further research is necessary for confirming the therapeutic effect of nitidine chloride in Wilms tumour. Funding: This work was supported by Natural Science Foundation of Guangxi, China (2018GXNSFAA294025); Guangxi Medical High-level Key Talents Training 139 Program (2020); Guangxi Medical University Training Program for Distinguished Young Scholars ; Medical Excellence Award Funded by the Creative Research Development Grant from the First Affiliated Hospital of Guangxi Medical University; Guangxi Degree and Postgraduate Education Reform and Development Research Projects, China (JGY2019050); Innovation Project of Guangxi Graduate Education; Guangxi Zhuang Autonomous Region Health and Family Planning Commission Self-financed Scientific Research Project (Z20200317); Innovation Project of Guangxi Graduate Education (YCSW2021121 Declaration of Interests: The authors have declared no competing interests. Ethics Approval Statement: All patients provided informed consent and approval of this research project was granted by the medical ethics committee of the First Affiliated Hospital of Guangxi Medical University (2020-ky-guoji-135). All experiments involving animals were conducted according to the ethical policies and procedures approved by the ethics committee of the First Affiliated Hospital of Guangxi Medical Univeristy (Approval no. 2020-ky-guoji-135).

Application and Practice of Teaching Methods of Mathematics Information in Higher Vocational Education

Since 2019, in response to the requirements of the 2019 government work report, higher vocational colleges have implemented an expansion of 1 million people. Higher vocational mathematics teaching exists and faces new problems and challenges. This article briefly introduces some informatization teaching tools and platforms. On this basis, a reasonable informatization teaching plan is formulated, and teaching materials are integrated and optimized. The specific application and practice of informatization teaching are carried out in the teaching classroom, and an effective feedback mechanism is proposed. The results have greater sharing and promotion value. Eventually realize the goal of training high-level, high-quality and high-skilled talents.

A Diagnostic Biomarker Model Associated with Immune Infiltration in Patients with Antibody-Mediated Rejection after Kidney Transplantation

Background: In spite of advances in development and application of immunosuppressive agents, the long-term survival of grafts still needs to be advanced caused by antibody-mediated rejection (ABMR). Many researchers have paid attention to this area. However, little was known about the role of genes and immune cells in the development of ABMR. Methods: In total, 2533 biopsy cases from four different cohorts were collected. Three Gene Expression Omnibus (GEO) datasets (GSE36059, GSE98320 and GSE12403) were used as the training set, and one GEO dataset and twenty biopsy samples from our center were used for validation. The potential diagnostic prediction value of the signature and immune profiles were also explored. Findings: The LASSO regression model and PPI network were performed to search candidate biomarkers. LAPTM5, GBP2, CCL5 and KLRD1 were obtained as diagnostic biomarkers (AUC = 0·934, 95% CI 0·923-0·943). Immune cell infiltration analysis revealed that γδ T cells which could secrete IL-17A were most related with four biomarkers. The infiltration of γδ T cells and IL-17A were significantly higher in ABMR group than that in ST group. Interpretation: We have identified and established a diagnostic model containing four transcripts as diagnostic biomarkers of ABMR following kidney transplantation. Several types of immune cells were inferred to be involved in the process of ABMR. Among these, γδ T cells were most related with four biomarkers, which may promote ABMR by producing IL-17A. Funding: This work was supported by the National Natural Science Foundation of China [grant numbers 82070769, 81900684, 81870512, 81770751, 81570676, 81470981, 81100532], Project of Jiangsu Province for Important Medical Talent [grant number ZDRCA2016025], the “333 High Level Talents Project” in Jiangsu Province [grant numbers BRA2017532, BRA2016514, BRA2015469], the Standardized Diagnosis and Treatment Research Program of Key Diseases in Jiangsu Province [grant number BE2016791], the Open Project Program of Health Department of Jiangsu Province [grant number JSY-2-2016-099], Jiangsu Province Natural Science Foundation Program [grant number BK20191063]. Declaration of Interest: None to declare. Ethical Approval: This study was approved by the local ethics committee of the First Affiliated Hospital of Nanjing Medical University (2016-SR-029).

ACE2 Overexpressing Mesenchymal Stem Cells Alleviates COVID-19 Lung Injury by Inhibiting Pyroptosis

Mesenchymal stem cells (MSCs) have shown some efficacy in the treatment of COVID-19, negatively express ACE2. We proposed that exogenous supplementation of ACE2 via MSCs (ACE2-MSCs) might have better therapeutic effects. Here, we constructed SARS-CoV-2 spike glycoprotein stably transfected AT -II and Beas-2B cells, and used SARS-CoV-2 spike pseudovirus to infect hACE2 transgenic mice. The results showed that spike glycoprotein transfection triggers the release of apoptotic bodies and formation of membrane pores in pyroptosis. Inflammatory factors and pyroptosis factors were highly upregulated by spike glycoprotein transfection. SARS-CoV-2 spike pseudovirus worsened lung injury and increased the main factors of cytokine storm and pyroptosis. Compared to using MSCs alone, the administration of ACE2-MSCs could much more significantly reduce these factors and alleviated lung injury in vivo and in vitro , which might be due to the increased activities of secretory ACE2. Our proposal is a promising therapeutic solution for preclinical or clinical research. Funding: This work was supported by grants from the Key Research and Development Program (Social Development) of Jiangsu Province (BE2020667), the National Natural Science Foundation of China (32070998), the Foundation of Jiangsu Province 333 Project High-level Talents (BRA2020076), Nantong Science and Technology Bureau (MS12020056), Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX21_3097) and Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: Animal studies were performed according to guidelines established by the Institutional Animal Care and Use Committee of Nantong University (permission number: S20200013-025).

Exploration and Practice of Innovative Ability Training of Master of Medicine under the Mode of Double Track Integration

Objective: Explore the new mode of innovative ability training for master of medicine under the mode of double track integration. Methods: Based on the current situation of talent development for master of medicine under the mode of double track integration, it focuses on the difficulties and problems, and starts with the scientific research thinking, innovative consciousness, the integration of clinical and scientific research, construction of platform and faculty, and searches reasonable countermeasures to improve the innovative ability for master of medicine. Results: Under the mode of double track integration, it can be effectively integrated from the five dimensions of diversified training system, industry-study-research mode, double supervisor system, construction of discipline and experimental platform, teacher training and high-level talents to provide guarantee for the training of innovative ability of master of medicine. Conclusion: In view of the current situation of talent development for master of medicine under the mode of double track integration, it will provide a feasible direction for innovative ability training of master of medicine by deepening integration.

Changes of Academic Career Mobility Policies in Universities in Northeast China

The free flow of university teachers can not only bring vitality and vitality to the academic ecosystem, but also the unity of the internal demands and external requirements of teachers' professional development. This paper mainly studies the development and changes of academic career mobility policy in Colleges and universities in Northeast China. With the help of the octopus data collector, this study carried out the main quantitative analysis of academic career mobility policy, supplemented by Excel 2013's later chart processing of the data. For the research problems, different research methods are used in this study. Through in-depth research on the relevant literature of academic career mobility, academic career mobility policy and policy text analysis, this study understands the research status of academic career mobility, policy and text analysis, defines the focus of this research, and seeks research methods and theoretical basis for the smooth development of research work. Due to the large time span and large number of academic career mobility policies involved in this study, in order to grasp the basic characteristics of the formulation of academic career mobility policies from a macro perspective and make a comprehensive quantitative analysis of the policy-making subjects, policy themes, policy objects and policy forms, this paper makes a secondary distinction between the elements involved in the policies, It constructs a structured coding and classification system of academic career mobility policy text. Among the policies related to academic career mobility issued in Northeast China, the university personnel system, high-level talent introduction policy, talent market policy and mobility supporting policies indirectly related to academic career mobility policy account for more, accounting for 25%, 24%, 22%, 16% and 11% respectively, and the overall proportion is 98%. It is of great significance to reduce the opportunity and time cost of academic career mobility, reduce the mobility risk of college teachers and increase the mobility income of college teachers.

Prediction of Superhard BN2 with High Energy Density* *Supported by the National Natural Science Foundation of China (Grant Nos. 12074154, 11904142 and 11722433), the Science and Technology Project of Xuzhou (Grant No. KC19010), the Six Talent Peaks Project and the 333 High-Level Talents Project of Jiangsu Province, and the Natural Science Research Projects of Colleges and Universities in Jiangsu Province

Considering that pressure-induced formation of short, strong covalent bonds in light-element compounds can produce superhard materials, we employ structure searching and first-principles calculations to predict a new class of boron nitrides with a stoichiometry of BN2, which are stable relative to alpha-B and alpha-N2 at ambient pressure. At ambient pressure, the most stable phase has a layered structure (h-BN2) containing hexagonal BN layers between which there are intercalated N2 molecules. At 25 GPa, a three-dimensional P42/mmc structure with single N–N bonds becomes the most stable. Dynamical, thermal, and mechanical stability calculations reveal that this structure can be recovered under ambient conditions. Its calculated stress-strain relations demonstrate an intrinsic superhard nature with an estimated Vickers hardness of ∼43 GPa. This structure has a potentially high energy density of ∼4.19 kJ/g.

General M-lumps, T -breathers, and hybrid solutions to (2+1)-dimensional generalized KDKK equation* *Project supported by the National Natural Science Foundation of China (Grant No. 11775116) and the Jiangsu Qinglan High-Level Talent Project.

A special transformation is introduced and thereby leads to the N-soliton solution of the (2+1)-dimensional generalized Konopelchenko–Dubrovsky–Kaup–Kupershmidt (KDKK) equation. Then, by employing the long wave limit and imposing complex conjugate constraints to the related solitons, various localized interaction solutions are constructed, including the general M-lumps, T-breathers, and hybrid wave solutions. Dynamical behaviors of these solutions are investigated analytically and graphically. The solutions obtained are very helpful in studying the interaction phenomena of nonlinear localized waves. Therefore, we hope these results can provide some theoretical guidance to the experts in oceanography, atmospheric science, and weather forecasting.

Eight-Year Medical Education Program: Retrospect and Prospect of the High-Level Medical Talent Training in China

Purpose: The 8-year medical education program (EYMEP) is China’s path to training high-level medical talents. In retrospect, this study systematically reviewed the developmental process of China’s EYMEP. The status quo and characteristics, and threats and challenges, were analyzed, along with the program’s prospects. Design/Approach/Methods: This study analyzed relevant textual materials and policy documents dating back to the time of hosting of China’s EYMEP, as well as conducted various specific interviews and field trips. Findings: The exploration of China’s high-level medical talent training has been conducted over a century. EYMEP can be divided into five periods: the Only Host Period, the Duplication Pilot Host Period, the Expansion Period, the Joint Exploration Period, and the In-Depth Promotion Period. Currently, there are 14 universities and institutes hosting the EYMEP approved by the Ministry of Education of the People’s Republic of China. However, they differ greatly in training ideas and goals, enrollment processes, and training phases. China’s EYMEP is faced with some external threats and internal challenges. In the future, China’s EYMEP should consider five aspects. Originality/Value: In the new era of the reform and development of China’s medical education, a systematic review of the development of EYMEP in China is of great significance to the promotion of high-level medical talent training in China. Meanwhile, the exploration course of China’s high-level medical talent training represented by the EYMEP may be an enlightenment for other countries, especially developing countries like China, in their training of high-level medical talents.

Marine Human Resource Supply Mechanism Based on Innovation Demand

Deng, S., 2020. Marine human resource supply mechanism based on innovation demand. In: Li, L. and Huang, X. (eds.), Sustainable Development in Coastal Regions: A Perspective of Environment, Economy, and Technology. Journal of Coastal Research, Special Issue No. 112, pp. 174-176. Coconut Creek (Florida), ISSN 0749-0208.With the economic development entering the new normal, China's coastal marine industry is gradually transforming and upgrading, which requires a large number of marine professional human resources. By supporting the optimization of talent team, talent innovation has become the competitive theme of the times, which will lead to severe test of marine professionals. With the “overcapacity” of middle and low-end marine talents, the problem of talent homogenization has become the main problem. Therefore, based on the innovation demand of marine industry, we should improve the supply mechanism of marine human resources, which will cultivate more skilled talents and high-level innovative scientific and technological talents. Under the strategic background one belt, one road, the demand for marine human resources will continue to increase, which needs to improve the supply mechanism of human resources. Combined with the marine economic industry and professional division of labor, we can improve the training output of marine economy advanced human resources based on innovation demand, which will strengthen the human resources supply mode shared by colleges and enterprises. Finally, some suggestions are put forward.

Thoughts on the Reform of Ideological and Political Teaching of “Tuina Manipulation”

Based on the current problems in the teaching of “Tuina Manipulation” course in our school, and the requirements of ideological and political teaching reform in the background of the new era, on the basis of consulting related literature and experience of actual teaching conditions, exploring the integration of ideological and political education elements into massage An effective way of teaching courses, put forward the ideas of Tuina ideological and political teaching reform. Ultimately, it will achieve the goal of “integrated” teaching of basic tuina courses, professional skills practice, moral quality improvement, comprehensive quality training, and training a group of high-quality and high-level Chinese medicine talents that meet the needs of social development.

Endostar Combined with Intensity-Modulated Radiotherapy in Low-Risk Local Advanced Nasopharyngeal Carcinoma: A Phase II, Randomized, Multicentric Clinical Trial

Background: A Phase II, randomized, prospective, multicentric trial (NCT02237924) was conducted to evaluate the efficacy and safety of Endostar plus radiotherapy in patients with low-risk local advanced nasopharyngeal carcinoma (NPC). Methods: From 09/2014 to 08/2016, patients with low-risk local advanced NPC were randomly treated with Endostar plus radiotherapy (ERT group, n=60) and concurrent chemoradiotherapy (CCRT group, n=60). Primary endpoint was the 5-year overall survival (OS) rate. The secondary endpoints were 3-year progression free survival (PFS) rate, OS rate, loco-regional recurrence free survival (LRRFS) rates and distance metastasis free survival (DMFS) rates. Findings: After a median follow-up of 47 months, 3-year OS rates were 93.2% and 79.3%, 3-year PFS rates were 89.8% and 70.6%, 3-year DMFS rates were 93.2% and 80.7%, in two groups, respectively (P 0.05). Moreover, the incidences of complications were significantly lower in ERT group. For short-term curative effects, CR rates were 70.0% and 60.0% for primary tumor, 73.3%and 65.0% for cervical lymph nodes, in two groups, respectively (P 0.05). Interpretation: OS, PFS, and DMFS rates can be improved, adverse events be reduced, with better tolerability, by Endostar plus radiotherapy, when compared to concurrent chemoradiotherapy for local advanced low-risk NPC. Trial Registration: (NCT02237924). Funding Statement: This work was supported by National Natural Science Foundation of China (No. 81760542), the Projects for Research and Development of Medical and Health Appropriate Technology of Guangxi Zhuang Autonomous Region (No. S2018087), the Key Research and Development Program of Guangxi (No. Guike AB18281003), Guangxi Medical University Training Program for Distinguished Young Scholars, and Medical Excellence Award Funded by the Creative Research Development Grant from the First Affiliated Hospital of Guangxi Medical University, “139” Program for high-level medical talents in Guangxi, Innovation Team of the First Affiliated Hospital of Guangxi Medical University. Guangxi Science and Technology Program Project (GK AD17129013), Simcere. Declaration of Interests: The authors declare that they have no competing interests. Ethics Approval Statement: This study was approved by the Ethics Committee of Guangxi Medical University. All procedures performed in the study involving human participants were in accordance with the ethical standards of the 1964 Helsinki declaration and its later amendments. Written informed consent was obtained from the patient and his/her immediate families.

Microstructure, optical, and photoluminescence properties of β-Ga2O3 films prepared by pulsed laser deposition under different oxygen partial pressures* *Project supported by the Guizhou Provincial Science and Technology Planning Project, China (Grant No. 2018-5781), the National Natural Science Foundation of China (Grant No. 51762010), the Guizhou Provincial Science and Technology Foundation, China (Grant Nos. 2020-1Y021 and 2020-1Y271), and the Guizhou Provincial

The β-Ga2O3 films are prepared on polished Al2O3 (0001) substrates by pulsed laser deposition at different oxygen partial pressures. The influence of oxygen partial pressure on crystal structure, surface morphology, thickness, optical properties, and photoluminescence properties are studied by x-ray diffraction (XRD), atomic force microscope (AFM), scanning electron microscope (SEM), spectrophotometer, and spectrofluorometer. The results of x-ray diffraction and atomic force microscope indicate that with the decrease of oxygen pressure, the full width at half maximum (FWHM) and grain size increase. With the increase of oxygen pressure, the thickness of the films first increases and then decreases. The room-temperature UV-visible (UV-Vis) absorption spectra show that the bandgap of the β-Ga2O3 film increases from 4.76 eV to 4.91 eV as oxygen pressure decreasing. Room temperature photoluminescence spectra reveal that the emission band can be divided into four Gaussian bands centered at about 310 nm (∼ 4.0 eV), 360 nm (∼ 3.44 eV), 445 nm (∼ 2.79 eV), and 467 nm (∼ 2.66 eV), respectively. In addition, the total photoluminescence intensity decreases with oxygen pressure increasing, and it is found that the two UV bands are related to self-trapped holes (STHs) at O1 sites and between two O2-s sites, respectively, and the two blue bands originate from at Ga1 tetrahedral sites. The photoluminescence mechanism of the films is also discussed. These results will lay a foundation for investigating the Ga2O3 film-based electronic devices.

The Construction of Human-oriented Applied “New Finance and Economics” Talent Training Model Based on Big Data

The cultivation of applied talents is the essential function of colleges and universities. Building a high-level application-oriented talent training system is the basic engineering requirement for deepening the talent training work in the era of computer big data. The construction of personnel training mode of new finance and economics is an important support for the renewal of financial technology in the new era[1]. It is also the main stage of the progress of the applied talents training system. This paper briefly describes the basic content of talent training system. This paper describes the main relationship between the new financial concept and the financial personnel training system. In addition, this paper puts forward the main point of view on how to build a high-level financial personnel training system in the era of computer big data.

Innovation Research of Network Technology in Music Teaching Environment

Internet multimedia has brought great convenience to people’s life.The teaching method of vocal music is also challenged by multimedia with the development of network.Universities as an important base of vocal music talents training in China provide a large number of high-quality and high-level vocal talents for the society every year.According to the actual situation of vocal music teaching in domestic colleges and universities, there is still a certain lag in teaching methods and teaching concepts.The network era has brought abundant teaching resources and broadened the way of knowledge transmission. The application of modern information technology is changing the traditional teaching methods in Colleges and universities. This paper analyzes the problems and innovation strategies in vocal music teaching in Colleges and universities, expounds the specific reform measures of college vocal music teaching innovation, and puts forward that we should make full use of network technology, expand vocal music course content, change vocal music teaching methods, enrich vocal music teaching practice, promote the construction of vocal music curriculum database, and constantly improve students’ vocal music skills and comprehensive artistic quality.

Strategic thinking to improve the basic research in liver transplantation in the new era

Liver transplantation(LT) is the "crown" of surgery and is also an important manifestation of national medical standards. In the past half century, China has made remarkable progress in LT. Currently, China is the second largest country of LT world widely and presents an international advanced level in the efficacy of LT. However, it is notable that there are still many bottlenecks to be solved in China. In the era of precision medicine and big data, the basic research of LT is largely lagging behind and unable to meet the rapid development of clinical needs. Strengthen the basic research of LT is a breakthrough strategy in rejuvenating the country through science and technology in the new era. A high-quality professional research team should be built through multi-disciplinary cooperation and superior resources gathering. Researcher's innovative thinking and strategic vision should be cultivated via the learning of new technologies (e.g., single-cell exploration and multi-omics analysis) and new courses (e.g., transplant oncology and transplant immunology). Government investment also needs to be increased to speed up the nurturing of high-level talents and get great achievements. Basic research is the driving force for China to become a leading country in LT.

Antimony Selenide Thin Film Solar Cells with an Electron Transport Layer of Alq3*Supported by the High Level Talents Project of Hainan Basic and Applied Research Program (Natural Science) (Grant No. 2019RC118), and the Open Fund of the State Key Laboratory of Molecular Reaction Dynamics in DICP (Grant No. SKLMRDK202005).

We fabricated Sb2Se3 thin film solar cells using tris(8-hydroxy-quinolinato) aluminum (Alq3) as an electron transport layer by vacuum thermal evaporation. Another small organic molecule of N,N’-bis(naphthalen-1-yl)-N,N’-bis(phenyl)benzidine (NPB) was used as a hole transport layer. We took ITO/NPB/Sb2Se3/Alq3/Al as the device architecture. An open circuit voltage (Voc) of 0.37 V, a short circuit current density (Jsc) of 21.2 mA/cm2, and a power conversion efficiency (PCE) of 3.79% were obtained on an optimized device. A maximum external quantum efficiency of 73% was achieved at 600 nm. The Jsc, Voc, and PCE were dramatically enhanced after introducing an electron transport layer of Alq3. The results suggest that the interface state density at Sb2Se3/Al interface is decreased by inserting an Alq3 layer, and the charge recombination loss in the device is suppressed. This work provides a new electron transport material for Sb2Se3 thin film solar cells.