The aim of the study was to establish the relationship between film-forming and adhesive properties of clinical isolates of Staphylococcus spp. Materials and methods. The study included 20 clinical isolates of S. aureus and 10 isolates of S. epidermidis obtained from purulent exudates in patients with infectious inflammatory diseases of soft maxillofacial tissues. Cultivation of these isolates was performed according to standard methods. The assessment of the adhesive properties of the clinical isolates of microorganisms under the study was performed using the standard method of V. I. Brillis et al. Adhesive properties were evaluated by the index of microorganism adhesion. The study of the film-forming property of clinical isolates was performed using the spectrophotometric method of MtP-test "microtiter plate test" by G.D. Christensen. The correlation coefficient (r-Pearson) was applied to determine the relationship between the variables. Results. Clinical strains of S. aureus have been found to possess high adhesive and film-forming properties. In turn, index of adhesion of clinical isolates of S. epidermidis indicates the moderate adhesive properties of the pathogen. Moreover, S. epidermidis showed a moderate ability to form biofilms. The study had shown a close relationship between the adhesion and film formation in clinical isolates of the genus Staphylococcus. Conclusions. Clinical isolates of S. aureus have been found to have high adhesive and film-forming properties. Isolates of S. epidermidis show a moderate ability to adhere and form biofilms. There is a direct strong correlation between the adhesive and film-forming properties of microorganisms of the genus Staphylococcus.