Gmelina arborea Roxb has important economic value in Nigeria and worldwide. It has been used as timber, for pulp and paper, furniture, plywood and for particle board. Due to the menace caused by fungal diseases in nurseries and sites where the seedlings are raised and the observed disease severity at the Awi Gmelina Forestry Project Nursery in Cross River State, Nigeria. It became necessary to provide a viable environmentally friendly measure to curb the diseases, hence, a trial on the antifungal effects of leaf extracts of Carica papaya and Azadirachta indica in-vitro using different extract solvents on some pathogenic fungi isolated from Gmelina arborea seedlings. The isolated fungi were Trichoderma viride (from stem and leaf) and Mucor mucedo (stem and leaf). The solvents used were ethanol, methanol, propanol, butanol, acetone, chloroform and distilled water. Phytochemical screening of extracts of C. papaya from the different solvents showed that there was no tannin and hydroxymethyl anthraquinine. Flavonoids and polyphenols were in excess in acetone and methanol extracts respectively. For A. indica, polyphenols were only found in excess in ethanol and methanol extracts. Application of the extracts at different percentages of 0% (control), 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% showed that Carica papaya extracted with butanol was more potent on Trichoderma viride and Mucor mucedo at 60%, 70%, 80% and 100% while the growth of Trichoderma viride and Mucor mucedo was checked by butanol extracts of A. indica at 70%, 80%, 90% and 100%. Conclusively, butanol extracts of C. papaya and A. indica at higher concentrations is recommended for use as spray to control the diseases.