Abstract
This research had the objective to validate the effect of the plant Azadirachta indica (neem) in human blood cells in a normoglycemic medium. This hypoglycemic effect had been attributed by the communities to this plant. This research is experimental, in which the aqueous extract of the plant was used in a concentration of 6.4% m/v and from this, were prepared the following doses: 0.01 mg; 0.05 mg (low doses); 0.1 mg; 0.175 mg (medium doses); 0.7 mg and 1.4 mg (high doses); also it was used insulin Humulin R ® in different concentrations (0.1, 1, 10 nM) in order to compare both effects in a normoglycemic medium with human blood cells. The results demonstrated a hypoglycemic effect when the levels of glucose concentration went down in the normoglycemic medium in relation to the control. There was a significant effect (p<0.001) for the high doses group. These findings validate the hypoglycemic effect of this plant attributed by the communities.
Highlights
Azadirachta indica, called neem, is an Asiatic origin arborous plant, from the region from India to New Guinea; it belongs to the meliaceae family, its height varies from 6 to 25 m, and the trunk diameter ranges from 1 to 1.6 m
The aim is to validate the hypoglycemic effect of this plant in human blood cells in normoglycemic medium, and verify the pharmacologic effects attributed by popular belief and surveys carried out in animals
The efficiency of the test designed to evaluate the glucose consume. It can be noted a progressive increase of the glucose consume in the medium, when it was added the insulin in a concentration of 10 nM since 1.5 until 5 minutes, in which is observed a quick glucose consume
Summary
Azadirachta indica, called neem, is an Asiatic origin arborous plant, from the region from India to New Guinea; it belongs to the meliaceae family, its height varies from 6 to 25 m, and the trunk diameter ranges from 1 to 1.6 m. This plant was introduced in Venezuela in 90’s, and it’s widely spread along the country (Reyes et al, 2003). The aim is to validate the hypoglycemic effect of this plant in human blood cells in normoglycemic medium, and verify the pharmacologic effects attributed by popular belief and surveys carried out in animals. There will be more reliable therapeutic alternatives that contribute to the diabetes mellitus treatment
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