Labor resources are one of the most difficult objects of management, as they are constantly developing and undergoing changes. The process of managing them in conditions of an unstable external environment becomes much more complicated. Such an environment was formed in Ukraine in 2022 as a result of the full-scale invasion of the Russian Federation. Therefore, the usual mechanisms of labor resource management had to be changed in order to maintain their effectiveness. The study of these changes and the consequences of their introduction determined the relevance of scientific research.The article identifies the problems faced by the domestic management, first in the conditions of the pandemic, and later – in the war. The role of the human resource management system in a modern company is determined. The essence of labor resources management has been studied, the methods by which it is carried out have been determined. The loss of relevance of developed personnel management tools was established due to fundamentally new conditions of their operation. The structure of organizational changes in domestic companies during martial law was analyzed, as well as changes among personnel according to the data of the European Business Association. A number of changes that companies plan to implement in the current year regarding work with personnel have been established. Aspects that must be taken into account in order to maintain the effectiveness of labor resources management are determined: worldview, methodological and applied. Recommendations are offered for solving problems in the field of labor resources management in terms of changing the practice of hiring employees, systematically assessing the state of psychological health, introducing the practice of multi-functionality of personnel, and their continuous training. The changes that have taken place in the field of research since the beginning of the war regarding the growing popularity of remote work, and as a result of the formation of the need to build new mechanisms of communication between employees and the development of a quality control system for such work, are summarized.