Diameter Collimator Research Articles

Determination of the beam quality correction factor for the PTW Semiflex 3D ionization chamber for the reference dosimetry at ZAP-X.

The self-shielding radiosurgery system ZAP-X consists of a 3 MV linear accelerator and eight round collimators. For this system, it is a common practice to perform the reference dosimetry using the largest 25mm diameter collimator at a source-to-axis distance (SAD) of 45cm with the PTW Semiflex3D chamber placed at a measurement depth of 7mm in water. Existing dosimetry protocols do not provide correction for these measurement conditions. Therefore, Monte Carlo simulations were performed to quantify the associated beam quality correction factor . The of the Semiflex3D chamber was computed from the ratio of the absorbed doses in a water voxel and in the sensitive air volume of the chamber simulated using a 60Co spectrum as the calibration beam quality (Qref) and the spectrum of the ZAP-X 3 MV photon beam (Qmsr). was computed as a function of measurement depth from 4 to 50mm. Furthermore, detailed simulations were performed to determine the individual chamber's perturbation correction factors by modifying the chamber's model step-wise. All perturbation correction factors, except Sw,air ⋅Pfl, show depth-dependent behavior up to a depth of 15mm. In particular, the volume-averaging Pvol and density Pdens perturbation correction factors and, consequently, the resulting gradient perturbation correction factor Pgr=Pvol∙Pdens increase with decreasing measurement depth. Therefore, is larger than unity, amounting to at 7mm measurement depth. At larger depths(>15mm), the can be considered as constant. At small measurement depths, was found to be depth-dependent with values larger than unity due to the gradient-related perturbation factors. Therefore, the uncertainty related to the chamber's positioning can be reduced by performing the reference dosimetry at ZAP-X at depths larger than 15mm, where can be regarded as depth independent.

A Monte Carlo study to evaluate and optimise the angular dependence of the Octa – A 2D silicon array detector used for dosimetry in stereotactic radiotherapy

PurposeA detector assembly based on a 2D silicon array sensor, Octa, was previously demonstrated to be accurate for small field relative dosimetry. Experimental studies showed angular dependence of the response that has also variations with the field size. A Monte Carlo simulation model was developed and used in this work to study how the detector assembly's components contribute to the observed angular dependence. MethodsGeant4 was used as the Monte Carlo code. A detailed model of the Octa detector and its packaging was placed in the centre of a solid water phantom with the central sensitive volumes (SVs) located at the isocentre and irradiated at polar angles from 0 to 180° (the beam was normal to the detector plane at 0°). Phase-space files from the IAEA database were used to model a CyberKnife X-ray beam with collimator diameters of 5, 10, and 15 mm. Reference simulations were compared with previous experimental results. To investigate the impact of the assembly's materials, simulations were conducted by iteratively substituting the non-water-equivalent materials of certain components with solid water. In terms of geometry, the influence of the dimensions of an air gap on top of the SVs and the silicon substrate thickness were investigated. ResultsPresence of the silicon surrounding the detector's SVs caused the highest decrease in energy deposition – up to (27 ± 1)%. Thickness of the air gap placed on top of the SVs had no effect at angles below 90°, but for 90–180°, it showed the largest impact on the variation in angular dependence between fields of different sizes – from (6 ± 2)% for 1 mm gap to (24 ± 2)% for 2 mm gap. The variation in the silicon substrate thickness and the air gap's lateral length, as well as presence of the PCB layer did not show significant influence on the angular response. ConclusionFurther development of the detector assembly's design can be driven by mechanical robustness to provide reliability for clinical routine without sacrificing angular dependence. Current design is recommended for use at angles 0–90°: it has shown independence of the angular response from small field size variation and it was previously optimised to be correction-free in output factor measurements. The air gap dimensions are recommended as the main variable parameters for optimisation for further studies when small X-ray beams are measured by the detector positioned in axial plane.

Experimental study on the effect of the milling condition of an aluminum alloy on subsurface residual stress

Aluminum alloys used in monolithic parts for aerospace applications are subjected to distortion and residual stress (RS) generated by milling, affecting the product fatigue life. Particularly, the change in RS with depth (z) has a characteristic distribution with a maximum compressive RS at a z several tens of micrometers from the surface; however, the RS value depends on the measurement method used. In this study, the RS distribution with z from the surface after milling was measured for the AA7050-T7451 aluminum alloy by two-dimensional X-ray diffraction (2D method). The results were compared with those of four prior measurement methods, and the validity of 2D method was verified. The changes in subsurface RS with z showed similar distributions under all measurement conditions except when cos(α)-XRD was employed. The 2D method provides high repeatability. The in-plane RS distribution was also measured using 2D method to investigate the effect of milling conditions on this distribution. The RS values varied markedly depending on the measurement position, particularly at a small collimator diameter of 0.146 mm, allowing detection of localized extreme RS values. The maximum RS at z = 0 mm was − 85.6 MPa at a cutting speed of vc = 200 m/s and feed per tooth of fz = 0.05 mm, while it was − 16 MPa for vc = 450 m/s and 6.8 MPa for fz = 0.2 mm, revealing that the compressive RS changes to tensile RS as vc and fz increase.

Feasibility Simulation of 3D Benchtop Multi-Pinhole X-ray Fluorescence Computed Tomography with Two Novel Geometries

In this work, we developed and validated two novel imaging geometries of benchtop multi-pinhole X-ray fluorescence computed tomography (XFCT) systems with Geant4 Toolkit. One of the Monte Carlo (MC) models utilized a fan beam source to illuminate a single slice of the object, a detector and a multi-pinhole collimator to image each slice’s X-ray fluorescence (XRF). The other model consisted of a cone-beam X-ray source (designed as a 5 mm wide fan beam to reduce simulation time) to scan the whole object, two detectors and two multi-pinhole collimators to image the emissions. The phantom used in the simulations included four sections, each with three cone-shaped gold nanoparticle (GNP) inserts (5 mm in height, 3 mm in diameter across the top) with center-to-center distances of 4 mm, 4.5 mm and 4.86 mm. The GNPs concentration was 0.1 wt. %, 0.3 wt. %, 0.5 wt. % and 0.7 wt. %, respectively. The diameter of the multi-pinhole collimator was 1 mm. Performance was evaluated for pinhole-detector-distance (PDD) of 5 cm, 3.5 cm and 2.5 cm, and the results for different object layers and for single pinhole and multi-pinhole (9 pinholes) imaging were compared. The data showed that results worsened with decreasing GNPs insert diameters and with decreasing PDD (object-pinhole-distance was fixed). The multi-pinhole configurations performed better than a single pinhole. The detection limit for the first multi-pinhole operation was 0.21 wt. %; the second was 0.24 wt. %. Detection limits for the single pinhole were 0.32 wt. % and 0.35 wt. %, respectively. The first MC model could acquire 2D slice images of the object without rotation and the second MC model could image the 3D object efficiently. These two novel multi-pinhole systems could potentially provide a bioimaging modality for nanomedical applications.

Comprehensive investigation of lateral dose profile and output factor measurements in small proton fields from different delivery techniques.

As a part of the commissioning and quality assurance in proton beam therapy, lateral dose profiles and output factors have to be acquired. Such measurements can be performed with point detectors and are especially challenging in small fields or steep lateral penumbra regions as the detector's volume effect may lead to perturbations. To address this issue, this work aims to quantify and correct for such perturbations of six point detectors in small proton fields created via three different delivery techniques. Lateral dose profile and output measurements of three proton beam delivery techniques (pencil beam scanning, pencil beam scanning combined with collimators, passive scattering with collimators) were performed using high-resolution EBT3 films, a PinPoint 3D 31022 ionization chamber, a microSilicon diode 60023 and a microDiamond detector 60019 (all PTW Freiburg, Germany). Detector specific lateral dose response functions K(x,y) acting as the convolution kernel transforming the undisturbed dose distribution D(x,y) into the measured signal profiles M(x,y) were applied to quantify perturbations of the six investigated detectors in the proton fields and correct the measurements. A signal theoretical analysis in Fourier space of the dose distributions and detector's K(x,y) was performed to aid the understanding of the measurement process with regard to the combination of detector choice and delivery technique. Quantification of the lateral penumbra broadening and signal reduction at the fields center revealed that measurements in the pencil beam scanning fields are only compromised slightly even by large volume ionization chambers with maximum differences in the lateral penumbra of 0.25mm and 4% signal reduction at the field center. In contrast, radiation techniques with collimation are not accurately represented by the investigated detectors as indicated by a penumbra broadening up to 1.6mm for passive scattering with collimators and 2.2mm for pencil beam scanning with collimators. For a 3mm diameter collimator field, a signal reduction at field center between 7.6% and 60.7% was asserted. Lateral dose profile measurements have been corrected via deconvolution with the corresponding K(x,y) to obtain the undisturbed D(x,y). Corrected output ratios of the passively scattered collimated fields obtained for the microDiamond, microSilicon and PinPoint 3D show agreement better than 0.9% (one standard deviation) for the smallest field size of 3mm. Point detector perturbations in small proton fields created with three delivery techniques were quantified and found to be especially pronounced for collimated small proton fields with steep dose gradients. Among all investigated detectors, the microSilicon diode showed the smallest perturbations. The correction strategies based on detector's K(x,y) were found suitable for obtaining unperturbed lateral dose profiles and output factors. Approximation of K(x,y) by considering only the geometrical averaging effect has been shown to provide reasonable prediction of the detector's volume effect. The findings of this work may be used to guide the choice of point detectors in various proton fields and to contribute toward the development of a code of practice for small field proton dosimetry.

Accelerator based epithermal neutron source for clinical boron neutron capture therapy

The world’s first accelerator based epithermal neutron source for clinical boron neutron capture therapy (BNCT) was designed, developed, and commissioned between 2008 and 2010 by Sumitomo Heavy Industries in collaboration with Kyoto University at the Kyoto University Institute for Integrated Radiation and Nuclear Science. The accelerator system is cyclotron-based and accelerates a proton up to an energy of approximately 30 MeV. The proton strikes a beryllium target, which produces fast neutrons that traverse a beam shaping assembly composed of a combination of lead, iron, aluminum, and calcium fluoride to reduce the neutron energy down to the epithermal range (∼10 keV) suitable for BNCT. The system is designed to produce an epithermal neutron flux of up to 1.4 × 10 9 n · cm − 2 · s − 1 (exiting from the moderator of a 12 cm diameter collimator) with a proton current of 1 mA. In 2017, the same type of accelerator was installed at the Kansai BNCT Medical Center and in March 2020 the system received medical device approval in Japan (Sumitomo Heavy Industries, NeuCure® BNCT system). Soon after, BNCT for unresectable, locally advanced, and recurrent carcinoma of the head and neck region was approved by the Japanese government for reimbursement covered by the national health insurance system.

Small field proton irradiation for in vivo studies: Potential and limitations when adapting clinical infrastructure

PurposeTo evaluate the dosimetric accuracy for small field proton irradiation relevant for pre-clinical in vivo studies using clinical infrastructure and technology. In this context additional beam collimation and range reduction was implemented. Methods and materialsThe clinical proton beam line employing pencil beam scanning (PBS) was adapted for the irradiation of small fields at shallow depths. Cylindrical collimators with apertures of 15, 12, 7 and 5mm as well as two different range shifter types, placed at different distances relative to the target, were tested: a bolus range shifter (BRS) attached to the collimator and a clinical nozzle mounted range shifter (CRS) placed at a distance of 72cm from the collimator. The Monte Carlo (MC) based dose calculation engine implemented in the clinical treatment planning system (TPS) was commissioned for these two additional hardware components. The study was conducted with a phantom and cylindrical target sizes between 2 and 25mm in diameter following a dosimetric end-to-end test concept. ResultsThe setup with the CRS provided a uniform dose distribution across the target. An agreement of better than5% between the planned dose and the measurements was obtained for a target with 3mm diameter (collimator 5mm). A 2mm difference between the collimator and the target diameter (target being 2 mm smaller than the collimator) sufficed to cover the whole target with the planned dose in the setup with CRS. Using the BRS setup (target 8mm, collimator 12mm) resulted in non-homogeneous dose distributions, with a dose discrepancy of up to 10% between the planned and measured doses. ConclusionThe clinical proton infrastructure with adequate beam line adaptations and a state-of-the-art TPS based on MC dose calculations enables small animal irradiations with a high dosimetric precision and accuracy for target sizes down to 3mm.

Overview on the progress of the conceptual studies of a gamma ray spectrometer instrument for DEMO

The future DEMO tokamak will be equipped with a suite of diagnostics which will operate as sensors to monitor and control the position and operation parameters of DT plasmas. Among the suite of sensors, an integrated neutron and gamma-ray diagnostic system is also studied to verify its capability and performance in detecting possible DEMO plasma position variations and contribute to the feedback system in maintaining DEMO DT plasma in stable conditions. This work describes the progress of the conceptual study of the gamma-ray diagnostic for DEMO reactor performed during the first Work-Package contract 2015–2020. The reaction of interest for this Gamma-Ray Spectrometer Instrument (GRSI) consists of D(T, γ)5He with the emission of 16.63 MeV γ rays. Due to DEMO tokamak design constraints, the gamma and neutron diagnostics are integrated, both featuring multi-line of sight (camera type), viewing DEMO plasma radially with vertical (12) and horizontal (13) viewing lines to diagnose the γ and neutron emission from the DT plasma poloidal section. The GRSI design is based on the investigation of the reaction cross sections, on the calculations performed with GENESIS and MCNP simulation codes and on the physics and geometry constrains of the integrated instrument. GRSI features long collimators which diameters are constrained by the neutron flux at the neutron detectors of the Radial Neutron Camera (RNC) system placed in front, which are key to control DEMO DT plasma position. For these reasons, only few GRSI parameters can be independently selected to optimize its performance. Among these, the choice of the collimator diameters at the back side of the neutron detector box up to the GRSI detector, the use of LiH neutron attenuators in front of the GRSI detectors, the GRSI detector material and shielding. The GRSI detector is based on commercial LaBr3(Ce) inorganic scintillating crystal coupled with a photomultiplier tube or a silicon photomultiplier. They are designed to operate at high count rate although GRSI geometry constraints severely impact on this feature. The GRSI can also provide an independent assessment of DEMO DT fusion power and T burning.

Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4

The Monte Carlo method is widely used in the Gamma Knife dose distribution calculations. In this study, Monte-Carlo simulation with Geant4 was applied to determine Leksell Gamma Knife dose distribution for homogeneous solid water and heterogeneous brain phantoms, and primarily focused on the differences arising from the effects of inhomogeneity. The relative dose graphs were displayed for different collimator diameters. The dose values from the maximal interval regions were determined and compared. It seen that when the collimator size was 4mm, the mean maximum relative dose point was at 47mm for water phantom and at 44mm for the brain. The difference found was about 6.38%. The differences among the results determined for water and brain were ranged from 2 to 17%. As a result, the inhomogeneity effect should be considered in dose calculation in Gamma Knife planning system.

Optical imaging of decayed positrons and muons with different collimators

Although optical imaging of decayed positrons and muons can provide promising methods, it has been attempted only for muons without a collimator, and the beam characteristics with collimators, such as peak position or beam spread in depth and lateral directions, have not yet been evaluated. Therefore, we conducted optical imaging of decayed positrons and muons with different collimators. For the imaging of decayed positrons, Cherenkov-light imaging in fluorescein (FS) water was used, while imaging of a plastic scintillator block was used for the imaging of muons. We conducted these imaging trials during irradiation with 84.5-MeV/c positive muons to an FS water phantom or a plastic scintillator block using a cooled charge-coupled device (CCD) camera with each collimator of a different diameter attached to the beam port. We could measure the Cherenkov-light images of FS water of decayed positrons and optical images of muons using the plastic scintillator block for all collimators. The depth profiles of the Cherenkov-light images were slightly wider for the muons with the collimators of larger diameters, although the estimated peak depths were nearly the same for all collimators. The lateral profiles of the Cherenkov light were wider for the muons when using collimators of larger diameters. Asymmetry in the directions of positron emissions from the muons was observed for all collimators. The depth profiles of the optical image of muons using a plastic scintillator block had nearly the same shape. The estimated lateral widths of the optical images of the plastic scintillator block were the same sizes as the collimator diameters within a 1.1-mm difference at a 10-mm depth of the scintillator block, and the widths were wider at the Bragg peak. With these measured optical images, we conclude that Cherenkov-light imaging of decayed positrons in water and optical imaging of muons using a plastic scintillator block with collimators are useful methods for determining not only peak position but also beam width as well as the asymmetry of the directions of positron emissions from the muons.

Output factor measurements with multiple detectors in CyberKnife® Robotic Radiosurgery System.

The aim of this study was to measure and compare the output factor (OF) of a CyberKnife Robotic Radiosurgery System with eight different small field detectors and validate with Technical Report Series (TRS) report 483. Accurate dosimetry of CyberKnife system is limited due to the challenges in small field dosimetry. OF is a vital dosimetric parameter used in the photon beam modeling and any error would affect the dose calculation accuracy. In this study, the OF was measured with eight different small-field detectors for the 12 IRIS collimators at 800 mm SAD setup at 15 mm depth. The detectors used were PTW 31016 PinPoint 3D, IBA PFD shielded diode, IBA EFD unshielded diode, IBA SFD unshielded diode (stereotactic), PTW 60008 shielded diode, PTW 60012 unshielded diode, PTW 60018 unshielded diode (stereotactic), and PTW 60019 CVD diamond detector. OF was obtained after correcting for field output correction factors from IAEA TRS No. 483. The field OFs in CyberKnife are derived from the measured data by applying the correction factors from Table 23 in TRS 483 for the eight small field detectors. These field OFs matched within 2% of peer-reviewed published values. The range and standard deviation showed a decreasing trend with collimator diameter. The field OF obtained after applying the appropriate correction factor from TRS 483 matched well with the peer-reviewed published OFs. The inter-detector variation showed a decreasing trend with increasing collimator field size. This study gives physicists confidence in measuring field OFs while using small field detectors mentioned in this work.

Treatment planning system and beam data validation for the ZAP-X: A novel self-shielded stereotactic radiosurgery system.

To evaluate the treatment planning system (TPS) performance of the ZAP-X stereotactic radiosurgery (SRS) system through nondosimetric, dosimetric, and end-to-end (E2E) tests. A comprehensive set of TPS commissioning and validation tests was developed using published guidelines. Nondosimetric validation tests included information transfer, computed tomography-magnetic resonance (CT-MR) image registration, structure/contouring, geometry, dose tools, and CT density. Dosimetric validation included comparisons between TPS and water tank/Solid Water measurements for various geometries and beam arrangements and end-to-end (E2E) tests. Patient-specific quality assurance was performed with an ion chamber in the Lucy phantom and with Gafchromic EBT3 film in the CyberKnife head phantom. RadCalc was used for independent verification of monitor units. Additional E2E tests were performed using the RPC Gamma Knife thermoluminescent dosimeter (TLD) phantom, MD Anderson SRS head phantom, and PseudoPatient gel phantom for independent absolute dose verification. CT-MR image registrations with known translational and rotational offsets were within tolerance (<0.5×maximum voxel dimension). Slice thickness and distance accuracy were within 0.1mm, and volume accuracy was within 0 to 0.11cm3 . Treatment planning system volume measurement uncertainty was within 0.1 to 0.4cm3 . Ion chamber point-dose measurements for a single beam in a water phantom agreed to TPS-calculated values within ±4% for collimator diameters 10 to 25mm, and ±6% for 7.5mm, for all measured depths (7, 50, 100, 150, and 200mm). In homogeneous Solid Water, point-dose measurements agreed to within ±4% for cones sizes 7.5 to 25mm. With 1-cm high/low density inserts, measurements were within ±4.2% for cone sizes 10 to 25mm. Film-based E2E using 4/5-mm cones resulted in a gamma passing rate (%GP) of 99.8% (2%/1.5mm). Point-dose measurements in a Lucy phantom with an ion chamber using 36 beams distributed along three noncoplanar arcs agreed to within ±4% for cone sizes 10 to 25mm. The RPC Gamma Knife TLD phantom yielded passing results with a measured-to-expected TLD dose ratio of 1.02. The MD Anderson SRS head phantom yielded passing results, with 4% TLD agreement and %GP of 95%/93% (5%/3mm) for coronal/sagittal film planes. The RTsafe gel phantom gave %GP of >95% (5%/2mm) for all four targets. For our first 58 patients, film-based patient-specific quality assurance has resulted in an average %GP of 98.7% (range, 94-100%) at 2%/2mm. Core ZAP-X features were found to be functional. On the basis of our results, point-dose and planar measurements were in agreement with TPS calculations using multiple phantoms and setup geometries, validating the ZAP-X TPS beam model for clinical use.

Integrating CVH and LVH metrics into an optimization strategy for the selection of Iris collimator for Cyberknife Xsight lung tracking treatment.

PurposeWe conducted this study to construct a target coverage‐volume histogram (CVH) and leakage‐volume histogram (LVH) metrics and optimization strategy for the selection of the Iris collimator in Cyberknife Xsight lung tracking treatment through a retrospective analysis of target structures and clinical data.Methods and MaterialsCVH and LVH metrics were retrospectively analyzed for 37 lung cancer patients. CVH and LVH were the same as dose‐volume histogram (DVH), but with a coverage and leakage replacing dose. For each patient, Iris collimator was optimized and selected based on CVH and LVH metrics. The CVH and LVH metrics were then compared to ascertain differences in 95% (C95) or 90% (C90) of the target coverage thresholds. The planning target volume (PTV) C95 and C90 coverage, absolute mean leakage value, leakage/coverage ratio, selected collimator diameter (Φ), Φ/length of the long axis of PTV (Amax), and Φ/length of the short axis (Amin) of PTV were compared. The correlation of the absolute mean leakage value, leakage/coverage ratio, Φ/Amin and Φ/Amax were evaluated.ResultsFor each patient, the PTV C95 coverage (70.45 vs 63.19) and C90 coverage (77.25 vs 69.96) were higher in the C95 coverage threshold group compared to the C90 coverage threshold group. The leakage/coverage ratio (0.56 vs 0.69) and absolute mean leakage value (0.56 vs 0.61) were lower in C90 coverage threshold group than in C95 coverage threshold group. The Spearmen correlation test showed the Φ/Amin were significantly correlated with leakage/coverage ratio and absolute mean leakage value. Upon analysis of the selected collimator diameters, the mean value of Φ/Amin of the optimized collimator diameters was found to be 1.10.ConclusionThe CVH and LVH analysis is able to quantitatively evaluate the tradeoff between target coverage and normal tissue sparing.

A novel and effective method for validation and measurement of output factors for Leksell Gamma Knife® Icon™ using TRS 483 protocol.

The objective of this work was to identify the exact location of the effective point of measurement (EPM) of four different active detectors to compare the relative collimator output factors (ROF) of Leksell Gamma Knife (LGK) according to IAEA TRS‐483 recommendations. ROF was measured at the center of the spherical LGK‐Solid Water (LGK‐SW) Phantom for three (4‐, 8‐, and 16‐mm in diameter) collimators using four (PTW‐TN60008, PTW‐TN60016, PTW‐TN60017, and PTW‐60019 diode/diamond) detectors. Since diode detectors have a much smaller sensitive volume than the PTW‐31010 ion chamber used for reference dosimetry, its EPM might not be at the center of the phantom, or (100, 100, 100) of the Leksell Coordinate System, particularly in the z‐direction. Hence for each diode detector, a CBCT image was acquired after it was inserted into the phantom, from which the z‐Leksell coordinate of EPM was determined. Relative collimator output factors was then measured by focusing GK beams on the determined EPM of each diode. Measured ROFs were compared with the vendor‐provided values in GK treatment planning system. For validation, a plan was generated to measure the output of 4‐mm collimator for PTW‐TN60017 at various couch locations along the z‐axis. For PTW‐TN60008, the percentage variations were 0.6 ± 0.4%, and −0.8 ± 0.2% for 4 and 8‐mm collimators, respectively. For PTW‐TN60016, the percentage variations were 0.8 ± 0.0%, and 0.2 ± 0.1%, respectively. The percentage variations were −3.3 ± 0.0% and −0.9 ± 0.1%, respectively, for PTW‐TN60017, and −0.5 ± 0.0% and −0.8 ± 0.2%, respectively, for PTW‐TN60019. Center of the measured profile for PTW‐TN60017 was only 0.1 mm different from that identified using the CBCT. In conclusion, we have developed a simple and effective method to determine the EPMs of diode detectors when inserted into the existing LGK‐SW phantom. With the acquired positional information and using TRS‐483 protocol, good agreements were obtained between the measured ROFs and manufacturer recommended values.

A Monte Carlo study of neutron contamination in presence of circular cones during stereotactic radiotherapy with 18 MV photon beams

High-energy photons are being used to treat different kinds of cancer, but it may increase the rate of secondary cancers due to the neutron contamination as well as over exposing of patients and medical staffs in radiation therapy Takam, Bezak, Marcu, and Yeoh, 2011, Radiation Research, 176, 508-520. Due to some difficulties in experimental measurements of neutron contamination, Monte Carlo method is an efficient tool to investigate dose parameters and characteristics in new techniques. The 18-MV photon beam of linac and circular cones have been simulated by MCNP5 code. Various parameters of photon and neutron including mean energy, flux, KERMA, the number of particles crossing a surface at a distance of 100 cm (SSD = 100 cm) as well as the change in photon and neutron spectrum as well as in intensity through the transmission in the circular collimators have been investigated. The results of this study show that the use of a circular collimator decreases neutron dose in the central axis, which is an advantage, but neutron contamination inducing small neutron dose is distributed all over the space. On the surface of phantom, photon dose rate is approximately equal to 3.41E7 (mGy/mA.min) for different collimators, but the neutron dose rate is 1.64E2 (mGy/ mA.min), 2.03E2 (mGy/ mA.min) and 2.52E2 (mGy/mA.min) for diameters of 12, 20 and 40 mm, respectively and it decreases by decreasing the diameter of the collimator. The neutron dose rate decreases from 9.68E7 and 9.74E7 (mGy/min.mA) for open field size 33 cm2 and 55 cm2 to 1.64E2 (mGy/min.mA), 2.02E2 (mGy/min.mA) and 2.52E2 (mGy/min.mA) for collimator diameter of 12 mm, 20 mm and 40 mm. It can be concluded that the use of circular collimators has an advantage of reducing neutron dose in the central axis. It should be mentioned that the off-axis neutron dose surrounding the collimator can be eliminated using an external neutron shield without perturbing the treatment field.

A study on determination of mass attenuation coefficient, effective atomic number and electron density of some materials using Monte Carlo method

This work aims to calculate the effective atomic number and electron density by Monte Carlo method. In previous studies, the most widely used solution is to use the transmission method with the narrow gamma-ray beam. In the approach of this work, the gamma-ray beam after going through material is uncollimated to recording by NaI(Tl) detector. To do this, the inner diameter of detector collimator was enlarged with the aim of decreasing the strengthen of radioactive source. The obtained results were compared with NIST data and the experimental values which yield the maximum deviation of 9.05% and 3.43%, respectively. These results show the promising approach in determining the features of material.

Multi-site evaluation of the Razor stereotactic diode for CyberKnife small field relative dosimetry

PurposeThe aims of this study were: (i) to validate in a multi-site context the suitability of the IBA Razor silicon diode detector for CyberKnife relative dosimetry. (ii) to fit the multi-center experimental data into a function relating the field output factors to the effective field size (EFS). Methods and materialsRatio of detector readings in clinical and reference field (OFdet) and beam profiles were acquired on five CyberKnife units for fixed collimator diameters (range 5–60 mm), using both Razor and PTW 60017 diodes. Measured OFdet were corrected using published MonteCarlo correction factors to get field output factors ΩQclin,Qmsrfclin,fmsr. Profiles were analyzed in terms of penumbra and EFS. ΩQclin,Qmsrfclin,fmsr obtained in four centers were fitted as a function of EFS, while the data of the 5th center were used to validate the fitting curve. ResultsDifferences between Razor and PTW60017 ΩQclin,Qmsrfclin,fmsr were within 1.5% over all centers down to 7.5 mm aperture and within 3.5% for the 5 mm diameter. The fit showed a coefficient of determination R2 = 0.997. The mean deviation of measured points from the predictive curve was within 0.5%. Data of the 5th center showed a mean deviation of 0.4% from the curve, with maximum differences within 2.5% for the 7.5 mm aperture. ConclusionsThe results confirmed the suitability of Razor detector for CyberKnife dosimetry by comparison to the PTW 60017 diode which has been well characterized and is in widespread use. The proposed mathematical relation between ΩQclin,Qmsrfclin,fmsr and EFS is a robust predictive model applicable to different CyberKnife systems and detectors.

Laser powder bed fusion of a pure tungsten ultra-fine single pinhole collimator for use in gamma ray detector characterisation

Laser Powder Bed Fusion is a leading additive manufacturing technology, whose use has been recently extended to refractory metals such as tungsten. This work was carried out to manufacture a pure tungsten pinhole collimator that would otherwise be difficult to produce using conventional methods such as machining. The laser powder bed fusion process was used to produce an ultra-fine 0.5 mm diameter hole running along a 40 mm long beam stop component. A laser powder bed fusion scanning strategy (laser energy density of 348 J/mm3) was selected with the aim of fabricating a high density tungsten component. The manufactured collimator was then used for gamma-ray detector characterisation. A collimated gamma-ray using a 241Am source mounted on an automated scanning table was used to study the gamma-ray interaction with respect to position in a semiconductor detector, so that the position-dependent charge collection process could be characterized. The 0.5 mm diameter fine tungsten collimator yielded a relatively narrower beam spot, leading to more accurate scan results. However that was at the expense of number of gamma rays detected per second. Overall, the 0.5 mm collimator allowed for higher resolution scans giving better detector characterisation results in comparison to a 1 mm diameter collimator.

Excessive applicator radiation leakage for a common therapeutic kilovoltage system.

The objective of this work is to characterise out- of- field leakage radiation emanating from clinical applicators of the WOmed T-200 kilovoltage therapy machine. To identify points of leakage, radiosensitive film was affixed to the walls and base plate of each applicator. Quantitative assessment of leakage radiation was conducted with a 0.23 cm3 ionisation chamber following the International Electrotechnical Commission standard. Film was also used to illustrate leakage distribution in the patient plane. Angular and energy dependences of the leakage radiation were quantified as well as a two-dimensional leakage profile in the plane parallel to one applicator. Leakage was found when the diameter of primary collimator of the kV tube exceeded the external dimension of the applicator wall. In the patient plane all applicators showed similar leakage rates with the leakage distribution dependent upon applicator design. Mean patient plane leakage was 1.37% of central axis air kerma rate, exceeding the 0.5% limit specified in the standard. Leakage was shown to be profoundly energy dependent with maximum leakage of 11.8% for the 200 kV beam, 1.3% for 150 kV and 0.2% for 100 kV. Angular dependence measurements showed a 10.3% change in leakage between the minimum and maximum positions. The combination of shielding thickness, primary collimator design and applicator dimensions permits unwanted radiation to contribute dose outside the treatment field when energies ≥150 kV are used. Even carefully designed modern kv therapy systems can exhibit leakage in some areas. Thorough assessment of leakage is needed prior to release for clinical use.

The effect of energy resolution of detection instrument on mass attenuation coefficient

The effect of energy resolution of two detection systems, HPGe and NaI(Tl), was determined by Monte Carlo (MC) calculation on mass attenuation coefficients of magnesium (Mg) and tungsten (W). In order to reveal the energy resolution effect, the detectors' collimator diameters were changed from 2 mm to 20 mm while sending collimated photon beams to the absorber material. It was observed that mass attenuation coefficients were increased with increasing collimator diameters. The performances of HPGe and NaI(Tl) detectors were quantified. The calculated results were compared with experimental results for Mg at energy of gamma rays 662 keV for different collimator diameters using both HPGe and NaI(Tl). It was observed that the MC calculation results were in a good agreement with the experimental data within the relative error from around 4% to 8%.