Aiming at the combined action effect of the corrosive environment of amphibious aircraft wading structures and random loads including water surface take-off and landing impact, based on the standard load spectrum TWIST of transport aircraft, considering the load level and frequency corresponding to the hydrodynamic load, the simulated random load spectrum of the wading structure was first compiled; the Willenborg/Chang high-load hysteresis model was used to consider the hysteretic effect of hydrodynamic high-amplitude overload on structural crack propagation, and an engineering method for damage tolerance analysis of amphibious aircraft wading structures was established. Taking the common hole edge crack of a typical wading structure of a certain type of aircraft as an example, based on the Franc3D crack propagation analysis software, the crack propagation life under the combined action of corrosive environment and random load spectrum was analyzed, and the inspection threshold value and check interval for maintaining the airworthiness of the structure were determined by residual strength analysis. The method proposed in this study is simple and feasible, and provides a theoretical basis for the damage tolerance analysis and maintenance plan formulation of amphibious aircraft wading structures.