The indices of colostrum macro and microelements from first milking after application of “Stimtel” medication to cows during the last 45 days of dry period were investigated. The study was conducted on cows of Ukrainian black-and-white breed. The cows on third trimester of pregnancy were divided in two groups: control and experimental. The animals were under the same feeding and maintenance conditions. For the cows of experimental group the “Stimtel” medication was applied. The constitutes of “Stimtel” medication are: iodine starch, vermiculite, chalk, lactic and carbonated compounds of Cobalt, Zink, Cuprum, Manganese, and Ferum. The medication was applied with concentrated feed in the dose of 35,6 g per animal daily during 45 days prior to planned parturition. The research material was colostrum of the first portion collected in 0,5 – 1,5 h after calving. The determination of content of macro and microelements was performed by spectrophotometric investigation of colostrum samples. The effectiveness of medication was assessed by its influence on the quantitative content of macro and microelements in colostrum. The application of “Stimtel” medication to cows of dry period reliably increases the level of Magnesium, Sodium, Potassium, Zink, and Cuprum in the colostrum of the first portion. Also, based on obtained data, the analysis of Potassium to Sodium ratio in the colostrum of first portion was performed. The usage of Calcium, Phosphorus, Nitrogen, and Carbon by animal organism depends on Potassium to Sodium ratio. The analysis of literature regarding the influence of macro and microelements deficiency in the colostrum and its influence on growth and immune status of newborn calves was performed. The application of the “Stimtel” medication allows to assume the positive influence of its mineral constitutes on the metabolism in calves during prenatal period, as well as during postnatal growth. Cows, which received the “Stimtel” medication were better provided with mineral substances essential for growth of fetus and, eventually, calves with bigger body mass and better clinical status were born, compared to the calves born from cows of control group. Assuming the data of physical examination of cows from economy and appearance of symptoms of Zinc, Cuprum, Ferum, Iodine, and Cobalt insufficiency and considering the relevant biogeochemical province where the economy is situated, it can be considered that colostrum of cows from both groups may contain insufficient level of others micronutrients, which were not investigated in current study, but which have significant effect on the body condition of newborn calves and their growth.