Cell-mediated transfer of immune protection factors to newborn calves

Lyudmila Proskurina,Elena Enns,Natalia Repsh,Margarita Simakova,Dmitriy Zamaratskiy

doi:10.1051/e3sconf/202020301030

Abstract

Immunocompetent cells in the blood, colostrum (milk) of cows and in the blood of newborn calves obtained from these animals give grounds to assert that newborn calves acquire cellular immune protection due to the intake of colostrum. With the colostrum of cows, not only nonspecific, but also specific immunocompetent cells enter the newborn’s body. The creation of colostral immunity is determined by the presence of a sufficient number of protective factors in colostrum and increased permeability of the intestinal histohematogenous barrier, which is capable of passing large immunoglobulin bodies and lymphocytes unchanged in the first 24-36 hours of life. A large number of specific immunocompetent cells found in colostrum is directly related to their increased content in the blood of these animals. The strength of the immune response depends on the preservation of immunological memory cells in the blood of revaccinated animals, some of which are represented in the pool of brucellin-reactive T-lymphocytes.

Highlights

The viability of the newborn to a certain extent depends on the level of immune protection factors acquired with colostrum in the first days of life
The number of B-lymphocytes was determined by the reaction of complementary rosette formation (EAC-RF) according to N
The data obtained by us from the study of immunocompetent cells in the blood, colostrum of cows and in the blood of newborn calves obtained from these animals give reason to assert that newborn calves acquire cellular immune protection due to the intake of colostrum

Summary

Introduction

The viability of the newborn to a certain extent depends on the level of immune protection factors acquired with colostrum in the first days of life. It is considered recognized that animals in the first days of life are characterized by immunological immaturity associated with poor development of lymphoid tissue and the absence of immunocompetent cells. We made an attempt to clarify the mechanism of transmission of immune factors (including specific immunocompetent cells) from cows vaccinated against brucellosis to newborn calves

Materials and methods

Research results

Findings

Conclusion