Abstract
This manuscript reports the finding of antibodies to the Colonization FactorAntigen I (CFA I) of human enterotoxigenic Escherichia coli in cows' colostrum and milk. This colonization factor is responsible for the adherence of certain strains of enterotoxigenic E. coli to the intestinal epithelium and antibodies to this factor are known to have a protective effect. Samples of cows' milk and colostrum were examined for the presence of antibodies to CFA I, by agglutination inhibition and ELISA. Relative amounts of specific antibodies were estimated and compared to that found in samples of an immunoglobulin concentrate obtained from the milk of vaccinated cows. The concentrations of antibodies to CFA I ranged from 0.55 to 5.2 μg/ml in colostrum samples of non-vaccinated cows.
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