Abstract
Colostrum is rich in various biologically active compounds such as immunotropic ones. Low molecular weight components were isolated from cow colostrum components (with a molecular weight of not more than 45 kDa). Their influence was investigated on intact Wistar Rattus norvegicus adult males in concentrations of 0.01, 0.1, 1.0 and 5.0 g/100 g of body weight. We determined content of lipid hydroperoxides and activity of serum glutathione peroxidase in blood serum, parameters of the bone marrow cells’ (BMCs) behaviour in the in vitro system (proliferation ability, morphologically identifiable and unidentifiable type of cells, lifespan of eosinophils). Morphological identifiable cells were stab neutrophils, segmented neutrophils, metamyelocytes, myelocytes, lymphocytes, basophils, neutrophils, eosinophils, monocytes. The low doses of colostrum components (0.01–0.10 g/100 g of body weight) did not affect the ratio of morphologically identifiable/unidentifiable cells. Administration of colostrum components at low doses (0.01 g/100 g of weight) increased the ability of BMCs to proliferate in the in vitro system. A super-large dose of colostrum components (5 g/100 g of body weight) was accompanied by a further loss of capacity for proliferation and cell death. Moreover, large doses of colostrum components resulted in change of balance to prooxidants (oxidants). The role of redox – system in BMCs functions was discussed. Large doses of colostrum components (1–5 g/100 g of body weight) were accompanied by a change of pro-antioxidant system balance. Only eosinophils were determined after administration of colostrum components in a large dose. It should be noted that the lifetime of eosinophils which developed under influence of colostrum components was greater than that of eosinophils obtained from control animals.
Highlights
Colostrum is a mixture of various substances with high biological activity that are formed in the mammary gland during the first few days after the beginning of lactation (Sanchez-Soto et al, 2017)
After the administration of colostrum components at the dose of 0.1 g/100 g of body weight, this indicator did not differ from the control but when the dose was increased 10 times, it increased by 115%
If the doses of colostrum components were increased 10 times, lipid hydroperoxides (LHP) increased by 115%
Summary
Colostrum is a mixture of various substances with high biological activity that are formed in the mammary gland during the first few days after the beginning of lactation (Sanchez-Soto et al, 2017) This unique composition of growth factors and immunomodulating components induces "triggering" and ensures the formation of the immune system of newborns, but "program" the metabolism of the developing organism. On the background of changes in indices of the redox system and the function of digestive disorders, the direction of differentiation of bone marrow stem cells can change In this regard, in the present study the number of cells in the bone marrow was determined in the work after administration of colostrum components of 0.01, 0.1, 1.0 and 5.0 g/100 g of body weight to mature rats (3.0– 3.5 months). The ratio of morphologically identifiable cells (lymphocytes, basophils, eosinophils, neutrophils, metamyelocytes, myelocytes, monocytes) to morphologically unidentifiable cells, the ability of BMCs to proliferation in the in vitro system and the time of preservation ("lifespan") of eosinophils in culture were determined
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call