Extract Of Coriandrum Sativum Research Articles

Influence of an aqueous extract of Coriandrum sativum leaves on the labeling of blood constituents with technetium-99m and determination of some of its physical parameters

Coriandrum sativum (coriander) extract (leaves) (CE) is used to treat diabetes, dyspepsia, loss of appetite, seizures, insomnia, and anxiety. In the investigations about the effects of a plant extract, it is important to determine some of its physicochemical parameters. Red blood cells labeled with technetium-99m (99mTc) is used in nuclear medicine as well as in experimental models in basic research. The aim of this work was to determine some physicochemical parameters of an aqueous extract of CE and its effect on the labeling of blood constituents with 99mTc. Determinations of the absorption spectrum (AS), electric conductivity (EC), and pH have been performed using different concentrations of CE. Results showed that CE had a maximum absorbance at 480 nm. EC was inversely correlated with the concentration. We found the highest value of pH at the lower concentration of the extract (0.05 mg/ml). There was no significant (P>0.05) alteration on the labeling of the blood constituents with 99mTc. In conclusion, physicochemical parameters could be useful to characterize the CE studied. Probably, the redox properties associated with the substances of this extract could be responsible by the absence of effect on the labeling of blood constituents with 99mTc. Key words: Coriandrum sativum, coriander, labeling, technetium-99m, physicochemical parameters, blood.

English

The efficacy of four concentrations of aqueous extracts of 11 local plants in the management of Aspergillus flavus and aflatoxin contamination was investigated by measuring the dry weight of A. flavus. The extracts of Allium sativum gave the best results, decreasing the dry weight of the fungus, followed by Aloe vera, whereas 20%Coriandrum sativum extract had no significant effect on the fungal dry weight. Aqueous 20% extracts of the herb Thymus vulgaris and the rhizome of Zingiber officinalis most strongly inhibited aflatoxin production for B1 (79.1%), followed by the leaf extracts of Olea europaea and Eucalyptus globulus (75.0%), although the effect on A. flavus growth was moderate. The herb T. vulgaris and extract of Ocimum basilicum leaf showed the strongest inhibition of B2 (76.2%). Conversely, the leaf extracts of Zizyphus spina andCassia italica produced only marginal effects on the percentage of inhibition of aflatoxins B1 and B2. No positive correlation was observed between mycelial growth and aflatoxin production in A. flavus. Key words: Maize, Aspergillus flavus, aflatoxin, aqueous plant extracts.

Variation of Antioxidant Activity and Phenolic Content of Some Common Home Remedies with Storage Time

The variation of antioxidant activity and total phenolic content of some plants commonly used as home remedies were screened on the basis of air drying time of (short term and long term air) the dried plant Ocimum sanctum (leaf), Cucumis sativus (Seed), and ethanolic extracts of Capsicum frutescens (Seed) and Coriandrum sativum (Seed). Antioxidant activities and total phenolic content values were estimated using DPPH reagent and Folin Ciocalteu reagent methods respectively. The antioxidant activity in short term air dried Ocimum sanctum plant methanol extract (IC50 = 0.03 ± 0.01 mg/l) was the highest among the other plant extracts. However, Coriandrum sativum plant ethanol extract produced higher phenolic content (70.24±3.4/66.57±4.1 mg/g) than other plant extracts. It was found that there was no correlation between antioxidant and phenolic content of these plant extracts.

Acute and sub-chronic toxicological evaluation of hydro-methanolic extract of Coriandrum sativum L. seeds.

Coriandrum sativum L. (CS) seeds are known to possess therapeutic potentials against a variety of physiological disorders. This study assesses acute and sub-chronic toxicity profile of hydro-methanolic extract of CS seeds using OECD guidelines. In acute toxicity study, mice were once orally administered 1000, 3000 and 5000 mg/kg body weight of CS extract. There were no any behavioral alterations or mortality recorded in CS treated groups. The LD50 value was more than 5000 mg/kg body weight. In the sub-chronic oral toxicity study, the animals were orally administered with CS extract (1000, 2000 and 3000mg/kg body weight) daily for 28 days whereas; vehicle control group received 0.5 % carboxy methyl cellulose. There was significant reduction in food intake, body weight gain and plasma lipid profiles of CS2 and CS3 (2000 and 3000 mg/kg body weight respectively) groups as compared to the control group. However, there were no alterations in haematological profile, relative organ weights, histology and plasma markers of damage of vital organs (heart, liver and kidney). The overall finding of this study indicates that CS extract is non-toxic up to 3000 mg/kg body weight and can be considered as safe for consumption.

Antioxidant, Antihyperglycemic, and Antihyperlipidemic Effects of Coriandrum sativum Leaf and Stem in Alloxan‐Induced Diabetic Rats

In India's indigenous system of medicine, Coriandrum sativum (CS), commonly used as a food ingredient, is claimed to be useful for various ailments. To establish its utility in diabetes mellitus, the present study evaluated the antidiabetic and antioxidant effects of CS in alloxan-induced diabetic rats. The extracts were shown to contain bioactive compounds including phenolics, flavonoids, steroids, and tannins. The extracts of CS in alloxan-induced diabetic rats were found to significantly lower blood glucose levels. Antidiabetic activity of the CS extracts was compared with the clinically available drug glibenclamide. The levels of serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were lower in the extract-treated group and high-density lipoprotein cholesterol was higher than the diabetic control rats. The extracts of CS exhibited strong scavenging effect on 2, 2-diphenyl-2-picrylhydrazyl free radical and inhibition of lipid peroxidation. The free radical scavenging effect of the extracts was comparable with that of the reference antioxidants. Furthermore, it also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in the liver of diabetic rats. These results indicate that the extracts could protect liver function and exhibited hypoglycemic, hypolipidemic, and antioxidant efficacies in the diabetic rats. These results support the use of this plant extract to manage diabetes mellitus. The leaves and stem of this plant Coriandrum sativum if used in cuisine would be a remedy for diabetes.

Antioxidant Properties of Coriandrum Sativum (Coriander)

Antioxidants prevent the damage done to cells by free radical‐molecules that are released during the normal metabolic process of oxidation. Some of these free radicals include reactive oxygen free radicals species (ROS), reactive hydroxyl radicals (OH), the superoxide anion radical (O2), hydrogen peroxides (H2O2) and peroxy (ROO) which generates metabolic products that attack lipids in cell membranes or DNA. These are associated with several types of biological damage, DNA damage; carcinogenesis and cellular degeneration related to aging and also contribute to heart disease and arthritis. Spice coriander reduces fever and promotes a feeling of coolness. It is highly beneficial in the deficiency of vitamin A, B1, B2, C and iron. High concentration of polyphenol and other bio reactive components are reported in this spice. The present study was aimed to determine the antioxidant properties of coriander. The antioxidant activity of polyphenolic extracts of Coriandrum Sativum was evaluated in vitro with the systronic Spectrophotometer at 517nm based on the reduction of the stable DPPH free radical. Total phenolic content extracted from the coriander spice sample was 240.0 mg GAE/g dry weight of the spice as estimated by Folin's reagent and calculated with standard curve prepared with gallic acid by the same procedure. Antioxidant activity measured from coriander as DPPH free radical scavenging activity was dose dependent. Incubation of 10μl of extract in DPPH free radical solution eradicated free radicals and caused decrease in OD of 0.01. Antioxidants present in coriander extract were able to protect DNA damage against hydroxyl ion caused by (ferrous sulphate + H2O2 + ascorbate) Fenton's reaction. The study indicate coriander is one of the most effective spice in terms of antioxidant properties and can serve as natural source to develop the free radical scavengers and antioxidant agents.

Effects of Coriandrum sativum extract on exploratory behaviour pattern and locomotor activity in mice: An experimental study

Background: Coriandrum sativum L. (coriander) is an annual herb belonging to the Apiaceae family, used for medicinal purposes. Objective: To investigate the effect of the hydroalcoholic extract obtained from Coriandrum sativum leaves on the exploratory behaviour pattern and locomotor activity of mice. Materials and Methods: Elevated plus maze (EPM) and open field test (OFT) were the screening tests used to assess the anxiolytic activity of, the extracts on mice. Diazepam (1 mg / kg) served as the standard anxiolytic agent. The animal receiving extracts or diazepam showed an increase in the time spent, total entries in the open arm of the EPM and increased total locomotion in the OFT, suggesting anxiolytic activity. Results: The crude dried extract was prepared in doses of 100, 200 and 400 mg / kg body weight and administered intraperitoneally to the mice, for evaluation of the anxiolytic activity. The 200 and 400 mg / kg body weight produced highly significant (P < 0.01) anxiolytic effects, in a dose-dependent manner, by increasing the time spent on and the number of entries into the open arms of the EPM and by an increase in the locomotion by mice in the OFT. Furthermore, in lower doses the extract did not affect the locomotor activity. Conclusion: Our findings demonstrated that the leaf extract of the plant exerted an anti-anxiety effect on mice in the elevated plus maze and open field test. Key words: Coriandrum sativum, diazepam, open field test, elevated plus maze

Larvicidal Activity of Selected Plant Extracts AgainstAedes albopictusSkuse (Diptera: Culicidae)

Plant-based insecticides may serve as suitable alternative as biocontrol techniques in the future. The present study has explored the effect of ether extracts of Emblica officinalis, Ricinus communis, Acacia coucinna, Cinnamomum tejpata, Piper nigrum, Coriandrum sativum, Olea vera, Linum usitatissimum, Syzygium aromaticum and Nigella sativa against larvae of Aedes albopictus under laboratory conditions. Larvae were exposed to a range of concentrations of each extract. The larval mortality was assessed after 24 and 48 hours exposure and LC50s were calculated for each time interval. All extracts showed moderate larvicidal activity. The lowest LC50 was found in Coriandrum sativum, Nigella sativa and Syzygium aromaticum at a dose of 363.7 ppm, 377.5 ppm and 403.4 ppm, respectively, after 24 h exposure while the amount of extracts used reduced to 263.9 ppm, 300.8 ppm and 342.2 ppm, respectively, after 48 h. In terms of lethal time response again Coriandrum sativum, Nigella sativa and Syzygium aromaticum showed less time to produce 50 % mortality (14.28, 17.77 and 17.99 h). These plants extracts are therefore promising as alternative to synthetic insecticides in mosquito control programmes. Thus providing the basis to use the plant extracts against Aedes albopictus.

In vitro free radical scavenging and DNA damage protective property of Coriandrum sativum L. leaves extract.

Coriandrum sativum L. (coriander), an everyday spice in the Indian kitchen is known to add flavor to the cuisine. It is an annual herb belonging to the Apiaceae (Umbellifera) family. The hydro-alcohol extract of Coriandrum sativum L. at the dose of 1mg/ml was subjected to a series of in vitro assays viz. 2, 2'- diphenyl-1-picrylhydrazyl, lipid peroxidation by thiobarbituric acid, reducing power and nitric oxide (NO) radical scavenging in order to study its antioxidant efficacy in detail. The amount of flavonoids in 70% ethanol extract was found to be 44.5μg and that of the total phenols was 133.74μg gallic acid equivalents per mg extract. The extracts of the leaves showed metal chelating power, with IC50 values, 368.12μg/ml where as that of standard EDTA was 26.7μg/ml. The IC50 values for 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid radical scavenging was 222μg/ml where as that of standard ascorbic acid was 22.6μg/ml. The NO scavenging activity of the extract of the leaves showed IC50 value of 815.6μg/ml; at the same time the standard BHA had 49.1μg/ml. All the plant extracts provided DNA damage protection; however, the protection provided at the dose of 8μg/ml was comparable to that of standard gallic acid. The Coriandrum sativum leaf extract was able to prevent in vitro lipid peroxidation with IC50 values; 589.6μg/ml where as that of standard BHA was 16.3μg/ml. Our results also showed significant ferric reducing power indicating the hydrogen donating ability of the extract. This study indicated the potential of the leaf extract as a source of natural antioxidants or nutraceuticals that could be of use in food industry with potential application to reduce oxidative stress in living system.

Opiate System Mediate the Antinociceptive Effects of Coriandrum sativum in Mice.

Our previous study showed that Coriandrum sativum (CS) has antinociceptive effects, but the mechanisms that mediate this effect are not clear. The present study was designed to test the role of opiate system in the antinociceptive effects of CS on acute and chronic pain in mice using Hot Plate (HP), Tail Flick (TF) and Formalin (FT) tests and also to compare its effect with dexamethasone (DEX) and stress (ST). Young adult male albino mice (25-30 g) in 33 groups (n = 8 in each group) were used in this study. CS (125 250, 500 and 1000 mg/Kg IP), DEX (0.5, 1 and 2 mg/Kg IP), vehicle (VEH) or swim stress were used 30 min before the pain evaluation tests. Acute and chronic pain was assessed by HP, TF and FT models. In addition, Naloxone (NAL, 2 mg/Kg, IP) was injected 15 min before the CS extract administration in order to assess the role of opiate system in the antinociception of CS. Results indicated that CS, DEX and ST have analgesic effects (p < 0.01) in comparison with the control group and higher dose of CS was more effective (p < 0.001). Besides, pretreatment of NAL modulates the antinociceptive effects of CS in all models (p < 0.001). The above findings showed that CS, DEX and ST have modulator effects on pain. These findings further indicate that the CS extract has more analgesic effects than DEX and ST and also provides the evidence for the existence of an interaction between antinociceptive effects of CS and opiate system.

Effects of Coriandrum sativum extract on exploratory behaviour pattern and locomotor activity in mice: An experimental study

Effects of Coriandrum sativum extract on exploratory behaviour pattern and locomotor activity in mice: An experimental study

Evaluation of inhibitory activity of extracts of Apium gravelens, Coriandrum sativum and Cuminum cyminum against number of pathogenic bacteria

Natural resources especially plants are useful bactericides for the control of bacterial infection .To evaluate the antibacterial potential of three types of plants, essential oils were extracted from the seeds of Apium gravelens, Coriandrum sativum and Cuminum cyminum and assayed in vitro for antibacterial activity aganist most prevalent pathogens Staphylococcus aureus, Salmonella spp.,Escherishia coli and Pseudomonas aeruginosa at 37 º C and 25 ºC.The antimicrobial effect was assessed using agar diffusion method by applying ethanolic solutions of extracts using it in two different temperatures 37 ºC and 25 ºC. The result shows that the extract of Apium gravelens, Coriandrum sativum and Cuminum cyminum alcoholic extract at 25 ºC exhibited an inhibition zone on S. aureus in the concentration 200 mg/ml and had a exhibited significantly (p &lt; 0.05) greater than that produced by gentamicine,also the extract of Apium gravelens at 25 ºC in the concentration 100 mg/ml had a significant antibacterial activity on S. aureus, and the extract of Apium gravelens alcoholic extract at 25 ºC and 37 ºC pronounced antibacterial activity against Pseudomonas aeruginosa in the concentration 100 and 200 mg/ml respectively moreover the inhibition produced by gentamicine. While the antibacterial effect Apium gravelens and Coriandrum sativum at 37 ºC on S. aureus in the concentration 200 mg/ml show very similar effect with gentamicine. The antibacterial activity against Salmonella spp.and E. coli were moderate in action It was found that the investigated extracts of Apium gravelens , Coriandrum sativum and Cuminum cyminum were exhibited a considerable inhibitory effect against S. aureus and extracts of Apium gravelens and Coriandrum sativum against P. aerogene. The significant antibacterial activity appears promising.

Picosecond nonlinear optical studies of gold nanoparticles synthesised using coriander leaves (Coriandrum sativum)

The results are presented from the experimental picosecond nonlinear optical (NLO) studies of gold nanoparticles synthesised using coriander leaf (Coriandrum sativum) extract. Nanoparticles with an average size of ∼30 nm (distribution of 5–70 nm) were synthesised according to the procedure reported by Narayanan et al. [Mater. Lett. 2008, 62, 4588–4591]. NLO studies were carried out using the Z-scan technique using 2 ps pulses near 800 nm. Open-aperture data suggested saturation absorption as the nonlinear absorption mechanism, whereas closed-aperture data suggested a positive nonlinearity. The magnitude of third-order nonlinearity was estimated to be (3.3 ± 0.6) × 10−13 esu. A solvent contribution to the nonlinearity was also identified and estimated. A comparison is attempted with some recently reported NLO studies of similar gold nanostructures.

Effect of solvents in extracting polyphenols and antioxidants of selected raw vegetables

Thirty-seven raw vegetables were extracted using four solvent systems: 70% acetone, 70% ethanol, 70% methanol, and distilled water. The extracts were tested for their total phenolic content, total flavonoid content and antioxidant activities (using diphenylpicryl-hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays). The results revealed the effect of different extracting solvents in altering the quantitative analyses of all vegetables and 70% acetone was identified as the most efficient solvent for extracting polyphenolic antioxidants from the vegetables. The highest total phenolic content and total flavonoid content were obtained from 70% acetone extract of Portulaca oleracea (138.2±2.1mg GAE/g dw basis) and 70% methanol extract of Cosmos caudatus (27.7±1.0mg QE/g dw basis), respectively. The 70% acetone extract of Etlingera elatior with moderate amount of total phenolic content exhibited the highest antioxidant activity in both assays. The correlation analyses within 37 different extracts of each solvent extraction demonstrated weak to moderate relationships between all the studied parameters. The highest r value of 0.7139 (p<0.001) was determined between total phenolic contents and FRAP values of the 70% methanol extracts. Meanwhile, a wide range of correlation coefficients was derived from correlation analyses within four different extracts of each vegetable, with the highest relationship between total phenolic contents and FRAP values for the extracts of Coriandrum sativum (r=0.9998, p<0.001).

Anti-anxiety activity of Coriandrum sativum assessed using different experimental anxiety models

Interest in alternative medicine and plant-derived medications that affect the “mind” is growing. The aim of present study was to explore the anti-anxiety activity of hydroalcoholic extract of Coriandrum sativum (Linn.) using different animal models (elevated plus maze, open field test, light and dark test and social interaction test) of anxiety in mice. Diazepam (0.5 mg/kg) was used as the standard and dose of hydroalcoholic extract of C. sativum fruit (50, 100 and 200 mg/kg) was selected as per OECD guidelines. Results suggested that extract of C. sativum at 100 and 200 mg/kg dose produced anti-anxiety effects almost similar to diazepam, and at 50 mg/kg dose did not produce anti-anxiety activity on any of the paradigm used. Further studies are needed to identify the anxiolytic mechanism(s) and the phytoconstituents responsible for the observed central effects of the hydroalcoholic extract of C. sativum.

Anticonvulsant effect of extract and essential oil of Coriandrum sativum seed in concious mice

Coriandrum sativum L. (coriander) has been indicated for a number of medial problems in traditional medicine such as loss of appetite, convulsion, and nervousness. We have previously shown that the aqueous extract of coriander has depressant effects on motor coordination and spontaneous activity, suggesting of a possible sedative and muscle relaxant effect. These findings suggest that coriander seed may have anticonvulsant effect as indicated in traditional medicine. Therefore, the aim of this study was to examine whether the extract or essential oil of coriander seeds have anticonvulsant effect. Mice were administered the aqueous, or 70% ethanolic extract or essential oil of coriander seed (200, 400, 600 and 800 mg/kg) or vehicle intraperitoenally 30 minutes before the injection of pentylenetetrazole (90 mg/kg). Diazepam (3 mg/kg) was used as a reference drug. Duration of time before onset of myoclonic, clonic and tonic convulsions, and number of animals that show convulsion and the percentage of mortality were recorded. The aqueous extract, hydroalcoholic extract and essential oil of coriander significantly increased the latency of myoclonic and clonic convulsions at doses of 600 and 800 mg/kg. Chi square for a linear trend showed that there is a significant linear relationship between the doses of coriander extract and essential oil and the protection against pentylenetetrazole-induced tonic convulsion and death. These findings strongly suggest that Coriandrum sativum seed possesses anticonvulsant activity and may have a value in the treatment of absence seizure.

Therapeutic efficacies of Coriandrum sativum aqueous extract against metronidazole-induced genotoxicity in Channa punctatus peripheral erythrocytes

Metronidazole (MTZ), a nitroimidazole drug, is primarily used as an anti-protozoan or an anti-bacterial agent in humans, although its genotoxic and carcinogenic effects have been widely reported, particularly in aquatic organisms. MTZ may induce DNA damages through single-strand breaks, modification of bases, DNA–DNA and DNA–protein cross-links, ultimately leading to apoptosis or necrosis. Here, we have assessed the genotoxicity of MTZ in the peripheral erythrocytes of Channa punctatus, using micronucleation (MN) and binucleation (BN) as genotoxicity markers. The therapeutic potential of aqueous extract of Coriandrum sativum against MTZ-induced genotoxicity has also been examined. The results show significant ( P < 0.05) increase in both MN and BN formation due to MTZ treatment. Such aberrations were higher in smaller fish samples for a particular dosage of MTZ, as established by correlation analysis between fish body weight and MN/BN count at P < 0.05. However, such degenerative damages were found to be alleviated by a great extent due to treatment with C. sativum leaf extract. Hence, we establish that MTZ can produce considerable degrees of micronucleus and binucleus formation in peripheral erythrocytes of C. punctatus, and such deleterious effect of MTZ treatment can be mitigated by aqueous extract of C. sativum leaves.

A study of the inhibitory effect of the Ethanolic extract of Cyperus rotundus , Eugenia caryophyllus and Coriandrum sativum on the in vitro growth of Candida albicans on a Sabouraud Dextrose Agar

The present study was designed to evaluate the inhibitory effects of three local plant ethanolic extracts (Cyperus rotundus , Eugenia caryophyllus and Cariandrum sativum ) against the growth of Candida albicans in culture media by using of agar well diffusion method. For this purpose graduate concentrates for each extract ( 25 , 50 , 100 , 150 , 200 , 400 )mg/ml prepared and tested .The result showed that the extract of Cyperus rotundus was more effective than Eugenia caryophyllus ,while Coriandrum sativum has no effect in all concentrates on Candida albicans. The statistical analysis by using ANOVA with LSD at level (p&lt;0.05) showed that the concentrations 200 , 400 mg/ml for Cyperus rotundus and 200 mg/ml for Eugenia caryophyllus were a significantly preeminence on the effect of other concentrations and from the effect of Nystatin and Clotrimazole .

Salinity impact on fruit yield, essential oil composition and antioxidant activities of C oriandrum sativum fruit extracts

This study is designed to examine the fruit essential oil composition, the total phenolic amounts and the antioxidant activities in methanolic extracts of Coriandrum sativum under saline conditions. Increasing NaCl levels to 75 mM reduced significantly the fruit yield by 36%. The essential oil yield was 0.30%, based on the dry weight; it increased by 77% and 84% at 50 and 75 mM NaCl, respectively, in comparison to the control. The major constituents were linalool and camphor, whose amounts increased with increasing NaCl concentrations. Antioxidant activities of the methanol extracts were determined by three different test systems, namely DPPH, β-carotene/linoleic acid and reducing power assays. In these three test systems, the highest activity was exhibited in control plants and was reduced significantly with increasing NaCl levels. In control plants, the total phenolic amount was 1.04 mg GAE/g DW which decreased by 43% and 66% at 50 and 75 mM NaCl, respectively.

Inflammatory bowel disease induced by intracolon instillation of acetic acid: screening study of the effects of different natural drugs

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is an autoimmune disease associated with altered immunological response, genetic susceptibility and intestinal microflora disorders. The main clinical manifestations are abdominal pain, diarrhea, mucous bloody and purulent stools, recurrent attacks, and relapse. The mainstream treatment of patients with IBD has been the use of anti-inflammatory, immunomodulatory drugs and antibiotics to relieve the symptoms. However currently available drugs are not universally effective and cause considerable adverse effects particularly for long-term therapy. Therefore, there is a pressing need for research that leads to the development of new therapeutic strategies for the treatment of IBD. In this context, as a phytotherapic approach, the effects of different plant extracts with anti-inflammatory properties were here investigated in a model of experimental colitis in rat. One hour after induction of colitis by intracolonal instillation of 4% (v/v) acetic acid, extracts of Coriandrum sativum L., Helichrysum italicum Dom., Aloe vera L., Cynara scolymus L., Zingiber officinalis Rosc., Boswellia carteri, Pistacia lentiscus L. (1000 mg/Kg) or dexamethasone (1 mg/kg), the last used as a reference drug, were orally administered. Body weight changes, fecal boli, occurrence of diarrhoea and well-being of the animals were examined 24 hour after induction of colitis. The severity of colitis was assessed by evaluating the macroscopic and microscopic changes of damaged colon and by the measurement of myeloperoxidase (MPO) activity. The analyses showed that the treatment with Coriandrum sativum L., Helichrysum italicum Dom., Aloe vera L., Cynara scolymus L., Zingiber officinalis Rosc. reduced ulceration and inflammation of colon and countered mieloperoxidase activity elevation. Moreover these extracts reduced microscopic damage as indicated by the decrease of neutrophil infiltration. The present results point out a protective effect of these extracts in experimental rat colitis induced by intracolon instillation of acetic acid, a reliable model for screening agents to potential benefits in IBD. Further studies are needed to better characterize the effect and the possible mechanism(s) of action of these extracts.