Abstract
Objective: To evaluate the antidiabetic and rejuvenating capability of tissues on alloxan induced diabetic rats under the effect of ethanolic leaf extract of Coriandrum sativum. Methods: Diabetic model was prepared by administration of alloxan monohydrate (150 mg/ kg i.p). The ethanolic leaf extracts of Coriandrum sativum at a dose of 200 and 400 mg/kg of body weight were administrated to diabetic induced groups for a period of 28 days. The effect of ethanolic leaf extract of Coriandrum sativum leaf extract on serum blood glucose, insulin, lipase, α- amylase and LDH as well as kidney function test [urea, uric acid, albumin, protein and creatinine] were measured in the alloxan induced diabetic rats. Results: In the acute toxicity study, ethanolic leaf extract of Coriandrum sativum leaf was non-toxic at 2 000 mg/kg in rats. The increased insulin level, albumin and protein level, decreased blood glucose and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of Coriandrum sativum leaf compared to diabetic control rats. In Histopathological study were revealed toward normal. Conclusion: Ethanolic extract of Coriandrum sativum leaf possesses significant antidiabetic and rejuvenating capability of tissues.
Highlights
Diabetes mellitus is chronicle disorders which are associated with many complications such as diabetic keto-acidosis, cardiovascular problems, kidney failure, eye damage, hyperosmolar coma and foot ulcers
The increased insulin level, albumin and protein level, decreased blood glucose and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of Coriandrum sativum leaf compared to diabetic control rats
The activity of serum glucose level (304.5±4.42 mg/dl) was significantly increased (p
Summary
Diabetes mellitus is chronicle disorders which are associated with many complications such as diabetic keto-acidosis, cardiovascular problems, kidney failure, eye damage, hyperosmolar coma and foot ulcers. In this study Metformin is used which is a biguanide anti-hyperglycaemic agent and used for controlling of blood glucose level without causing hypoglycemia.[6] Today’s focus on the diabetes is controlling to keep blood glucose, lipid levels within a normal range and to prevent related complication, improve patient satisfaction and quality of life.[7,8]
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