Objectives: This study examines dental hygiene students’ knowledge of and compliance with coughing etiquette; it also seeks to identify factors that influence dental hygiene students’ compliance with coughing etiquette. Methods: An online questionnaire was distributed to students currently majoring in dental hygiene at two colleges in the Busan area. The subjects were informed of the purpose of the study; all participants provided informed consent to take part in the study. Results: The findings show that factors that impact compliance with coughing etiquette include knowledge of coughing etiquette, carrying tissues, and awareness of coughing etiquette. Conclusions: Dental hygiene students’ compliance with coughing etiquette was significantly influenced by knowledge of coughing etiquette, carrying tissues, and awareness of coughing etiquette