Over the past millennia, the Sea of Azov has undergone a number of very significant changes in the hydrological regime, salinity, and boundaries of biological communities. An increase in the salinity of the waters of the Azov Sea up to 15 ‰ was noted many times. This suggests that the current "record" salinity levels from a historical point of view are not extreme. According to forecasts of changes in the level of the World Ocean, one should expect another transgression and intensive pontization of the Sea of Azov. This creates the preconditions for a long-term forecast of a change in the basic fishing objects in the Sea of Azov from a group of pontic relicts to Mediterranean invaders and introduced species.