Carbon Dots In article number 2213856, Qing-Ying Luo, Kelong Fan, Minrong Zhu, and co-workers develop a red emissive carbon dot nanozyme with high superoxide dismutase (SOD)-like activity over 4000 U mg−1. The SOD nanozyme activity is revealed to be relying on their surface functional groups which capture O2•− and then promote the electron transfer between O2•− and π-system of carbon dot. The carbon dot SOD nanozyme shows great potential in bioimaging and ameliorating acute lung injury.