The medicinal plants, like Alhagi maurorum, have received great attentions, especially by food scientists and manufacturers as natural food preservatives due to their antimicrobial and antioxidant activities. In this study, the effects of extracting solvents, namely, hexane, water, and acetone, individually or in combination with each other according to especial cubic mixture design, as extracting solvent were evaluated on antioxidant and antibacterial activities of Alhagi maurorum extracts against Staphylococcus aureus, Bacillus cereus, Escherichia coli, Citrobacter freundii, and Pseudomonas aeruginosa as main food pathogenic strains. Various empirical models were then offered in order to predict the antibacterial and antioxidant of extracts by extracting solvent composition, with quite high coefficients of determinations (R2 > 84%). It has resulted that the extracting solvent composition had significant effects on biological and chemical characteristics of attained extracts. Due to the high antibacterial and antioxidant effects of extracts, they can be successfully used as natural food preservatives. Practical applications The Alhagi maurorum extracts were fabricated using the best multicomponent extracting solvent system and the gained extract showed the greatest antioxidant or antibacterial activities, against common food pathogen strains. Thus, it can be successfully used in various food and beverage formulations as plant-based natural preserver and nutrition enhancer with health promoting activities.