Alhagi Maurorum Research Articles

A human study on the effect of Alhagi Maurorum (camel thorn) on patients suffering from hepatitis B virus

A human study on the effect of Alhagi Maurorum (camel thorn) on patients suffering from hepatitis B virus

Forage potential of several halophytic species grown on saline soil in arid environments

This study was carried out to evaluate the forage quantity and quality of several halophyte species grown in arid-saline environments. After identifying 44 halophytic species in the region and considering the potential of quantitative and qualitative forage production, 13 species from four families, i.e. Amaranthaceae, Asteraceae, Leguminosae and Convolvulaceae, and eight genera were selected for further evaluation. These species differed significantly in terms of both forage quantity, measured in terms of fresh (FW) and dry weight (DW), and forage quality assessed in terms of tissue water content (TWC), ash, nitrogen content (N), crude protein (CP), acid detergent fiber (ADF), neutral detergent fiber (NDF), dry matter digestibility and metabolizable energy (ME). The highest fresh and dry weights were obtained from Suaeda ferticosa (1006.3 g and 306.3 g, respectively) and Noaea mucronata (909.3 g and 309 g, respectively). However, based on forage quality characteristics, Alhagi maurorum, Bassia scoparia, Noaea mucronata, Halostachys belangriana and Cressa cretica showed the best forage potential. Values of ash, CP, ADF, NDF and ME measured in the halophytes species ranged between 7.9% and 33.2%, 6.2% and 15.8%, 30.0% and 50.3%, 33.2% and 56.4%, 5.6 and 8.7 MJ kg−1, respectively. The forage quality of the evaluated halophytic plants was influenced by unfavorable environmental conditions such as high soil salinity and low rainfall, however, these species can be considered as new sources of forage. Nevertheless, further studies are needed to improve the quality of such halophytic species by reducing the ash content and increasing the ME.

Assessment and Reserve of Some Feed Phytocoenoses

The studies were carried out on the floristic, geobotanical and resource assessment in Zardab and Ujar districts in 2020-2021 and 87 species belonging to 12 families were registered in the composition of coenosis. 12 species (Poa bulbosa L., Poa pratensisL., Artemisia lerchiana Weber, Chenopodium album L., Bromus scoparius L., Alhagi maurorum Medik., Cynodon dactylon (L.) Pers., Climacoptera crassa (M. Bieb.), Stipa capillata L., Brassica napus L., Glycyrrhiza glabra L., Alyssum tortuosum Willd. (= Odontarrhena tortuosa (Waldst. et Kit. ex Will.) C. A. Mey.)) distinguished for their long-term participation in the composition of the groupings were determined. The dynamics of productivity in coenoses were assessed by seasons and it was found that they changed in the range of 1.44-1.91 hwt/ha (in spring), 0.65-1.55 hwt/ha (in summer), 1.02-1.76 hwt/ha (in autumn). The dominance of forbs on botanical groupings was revealed.

Physicochemical and control releasing properties of date pit (Phoenix dactylifera L.) phenolic compounds microencapsulated through fluidized-bed method.

This study aimed to investigate the effect of different ethanol/water solvents on phenolic compound extraction and microencapsulated extract of date pit powder. The highest and the lowest amounts of total phenolic compounds were 742.37 and 236.07 mg GAE/g dm, respectively, observed in water-ethanol composite solvent (25% W: 75% E) and water solvent (100% W). In this regard, the highest and lowest values of IC50 were 6.83 and 0.90 μg/ml, measured in water solvent (100% W) and water-ethanol solvent (25% W: 75% E), respectively. In the second phase, using maltodextrin (10%, 20%, and 30% W/V) as the first layer, date pit extract was microencapsulated. Alhagi maurorum gum (10%, 20%, and 30% W/V) as the second layer and medium-chain triglycerides (MCT oil) (15% W/W) as the third layer were used by a fluidized-bed drying technique. By increasing temperature, the microencapsulated extract powder solubility was increased as well. In contrast, the moisture content, bulk density, tapped density, and compressibility index decreased. By increasing temperature, the maltodextrin and A. maurorum gum concentration, the coating efficiency, and the loading capacity of the samples increased initially and decreased eventually. Moisture content, powder solubility, bulk density, and compressibility index increased, with increasing maltodextrin concentration, however, tapped density decreased. The optimal physicochemical properties of the phenolic compounds' microcapsules were determined at 45°C and at a concentration of 20% of each of the maltodextrin and A. maurorum gum. According to scanning electron images, the powder particles were spherical and had a relatively smooth surface. Notably, the release rate of phenolic compounds reached its maximum (64%) after 24 h.

Bioaccumulation of Heavy Metals in a Soil–Plant System from an Open Dumpsite and the Associated Health Risks through Multiple Routes

Screening various plant species to act as hyperaccumulators and associated health risks could serve as a sustainable solution for the bioremediation heavy metals (HMs). For the first time, the present study explored the phytoremediation potential of native plants, soil enrichment, and human health risks associated with the contamination of HMs in soil and plant samples collected from a municipal solid-waste open dump site. Soil and plant samples (n = 18 + 18) from the dumpsite and (n = 18) from the control site were analyzed for selected HMs, i.e., Chromium (Cr), Lead (Pb), Nickel (Ni), Iron (Fe), and Zinc (Zn). The phytoremediation potential of plants was assessed using the bioaccumulation factor (BAF), bioaccumulation coefficient (BAC), and translocation factor (TF), while soil pollution levels were evaluated using the contamination factor (CF), geoaccumulation index (Igeo), enrichment factor (EF), potential ecological risk index (PERI), and human health risk indices. The results revealed that based on TF and BAC values, Alhagi maurorum Medic., Astragalus creticus Lam., Cichorium intybus L., Berberis lycium Royle, and Datura stramonium L. were hyperaccumulators for Cr while Parthenium hysterophorus L. was a promising species for both Ni and Cr. Similarly, CF values for Fe, Ni, Pb, and Cr were >6, thereby showing very high contamination, while Igeo values for Fe, Ni, Pb, and Cr were (class 6, >5), showing that the soil was extremely polluted. Furthermore, EF values for Fe, Ni, Pb, Cr, and Zn were 2 < EF ≤ 5, depicting moderate enrichment, while PERI values were in the range of 91.31–195.84, employing moderate ecological risks (95 < PERI < 190) from the dumpsite’s soil. Moreover, for non-carcinogenic exposure, none of the analyzed metals exceeded the threshold limit HRI values > 1 in both adults and children. Likewise, in the case of carcinogenic effects, the CRI values were lower than the tolerable limits (1 × 10−6–1 × 10−4) in both adults and children. Moreover, almost all studied plants could be utilized for the phytoextraction of mentioned HMs. In future, the present study can help in the implementation of public policies to ensure sustainability and developmental activities in contaminated sites. Based on these results, it is concluded that there is a dire need of monitoring solid waste dumpsites due to various types of potential risks associated with the contamination of HMs. Moreover, to minimize the potential health problems arising from the dumpsite, it is substantive that special attention should be paid to work on sustainable and eco-friendly remedial measures.

Alhagi maurorum Ethanolic Extract Rescues Hepato-Neurotoxicity and Neurobehavioral Alterations Induced by Lead in Rats via Abrogating Oxidative Stress and the Caspase-3-Dependent Apoptotic Pathway.

This work investigated the probable protective effect of an Alhagi maurorum ethanolic extract on the hepatotoxicity and neurotoxicity accompanied by neurobehavioral deficits caused by lead in rats. Rats in four groups were orally administered distilled water, ethanolic extract of A. maurorum (300 mg/kg BW daily), lead (100 mg/kg BW daily for 3 months), and lead + A. maurorum extract. The results demonstrated that lead exposure resulted in elevated locomotor activities and sensorimotor deficits associated with a decrease in brain dopamine levels. Moreover, lead exposure significantly increased liver function markers. In addition, the lead-treated rats exhibited extensive liver and brain histological changes and apoptosis. The lead treatment also triggered oxidative stress, as demonstrated by the increase in malondialdehyde (MDA) concentrations with a remarkable reduction in the activities of antioxidant enzymes, reduced glutathione (GSH) levels, and transcriptional mRNA levels of antioxidant genes in the liver and brain. Nevertheless, co-treatment with the A. maurorum extract significantly ameliorated the lead-induced toxic effects. These findings indicate that the A. maurorum extract has the ability to protect hepatic and brain tissues against lead exposure in rats through the attenuation of apoptosis and oxidative stress.

A field study to restricted poisonous wild plants grown in Al-Kharj region, Saudi Arabia

This study was aimed to define and collect different poisonous plant species that grow in Al-Kharj region, Saudi Arabia and are detrimental to human and livestock. A total of 16 plant species belonging to 12 families were recorded in the current study. These plants were met through surveys conducted by herbalists and smart citizens with skills and experience in the field of toxic plants in the region. For each species reported, botanical and vernacular names, families, and toxic principles are recognized. The most dominant and widespread toxic flowering plants reported in the studied area were the clan of Calotropis procera and Rhazya stricta. Other less widespread poisonous plants such as Citrullus colocynthis, Heliotropium bacciferum, Cassia italica, Alhagi maurorum, Capparis spinosa, Tribulus terrestris and Euphorbia helioscopia as well as Convolvulus arvensis, Zygophyllum coccineum were also observed.

Green synthesised CuNPs using Alhagi maurorum extract and its ability to amelioration of Mycoplasma pneumoniae infected pneumonia mice model

In this study, copper nanoparticles were synthesised according to green chemistry rules using the aqueous extract of Alhagi maurorum. The green-synthesised CuNPs were characterised using different techniques such as EDX, FE-SEM, XRD and FT-IR. The FE-SEM results confirm spherical morphology for the nanoparticles with a size of 42.68–68.87 nm. In vivo, the Mycoplasma pneumonia injection was applied for inducing pneumonia in the BALB/c mice, also the treatment was with CuNPs. The serum parameters such as inflammatory mediators (IL-6, TNF-α, IL-8, TGF and IL-1), total cell counts, and total protein content levels were evaluated. CuNPs regulated the levels of the inflammatory mediators in the infected mice. The cellular arrangements at the histopathological images were ameliorated with the administration of CuNPs. At the antioxidant test, the CuNPs and BHT removed 50% of free radicals at the concentrations of 181 and 110 µg/ml. In conclusion, the results revealed the ameliorative property of CuNPs green-formulated by A. maurorum aqueous extract on M. pneumoniae infected pneumonia mice model.

Relationship between soil salinity and alkalinity with Alhagi camelorum growth in hypersaline and hyperarid environments

In this research, the growth and distribution of Alhagi camelorum Medic. as a potential crop was monitored for producing forage in hypersaline and hyperarid regions. For this purpose, seven Alhagi-dominated rangelands were selected in its original homeland at the south of the Great Salt Desert. The soil salinity of selected regions is very variable, and ranged from 3.6 dS m−1 to 725 dS m−1 and from 0.4 dS m−1 to 366 dS m−1 at 0–30 cm and 30–60 cm soil depths, respectively. The annual mean of maximum and minimum air temperature is around 30 and 6 °C, respectively, and the mean annual precipitation is less than 150 mm. The plant growth characteristics assessed by canopy cover, canopy height, shoot fresh weight (SFW), and dry weight (SDW) had a negative relationship with soil salinity and pH. The highest SFW (24.97 t ha−1) and SDW (6.98 t ha−1) of Alhagi were obtained where soil salinity was 13 dS m−1 and soil pH was the lowest (7.1). Alhagi maintained the minimal growth and production of 20 cm canopy height and 50% canopy cover even in the saltiest conditions with a soil salinity of 395 dS m−1; hence it can serve as a potential crop for haloculture systems. In Aqda, the canopy cover increased with increase in the soil salinity up to 7–10 dS m−1 but decreased as the salinity levels increased further. The study revealed that A. camelorum not only has a very high tolerance to salinity but a moderate salinity up to 10 dS m−1 can also stimulate the growth. However, soil pH had a greater effect on growth, and Alhagi does not have a high tolerance to soil alkalinity. Therefore, Alhagi species could not be a bio-indicator for soil salinity, while well-established plants with good canopy could be considered as a sign for low alkalinity in arid terrestrial ecosystems.

Green synthesis, characterization and determination of anti-prostate cancer, cytotoxicity and antioxidant effects of gold nanoparticles synthesized using Alhagi maurorum

• The results of the AuNPs have revealed that the recent NPs has been formulated as the best. • AuNPs has anti-human prostate cancer activities. • AuNPs has antioxidant potentials. In the present study, gold nanoparticles were green-synthesized using the aqueous extract of Alhagi maurorum leaf aqueous extract. The synthesized AuNPs were characterized by analytical techniques including TEM, UV–Vis., and FT-IR. The nanoparticles were formed in a spherical shape in the average size of 18.36 nm. In the oncological part of the recent study, the treated cells with AuNPs were assessed by MTT assay for 48 h about the cytotoxicity and anti-prostate carcinoma properties on normal (HUVEC) and prostate carcinoma cell lines i.e. DU 145, NCI-H660, 22Rv1, and LNCaP clone FGC. The viability of prostate carcinoma cell lines reduced dose-dependently in the presence of AuNPs. The IC 50 of AuNPs were 229, 368, 298, and 222 µg/mL against DU 145, NCI-H660, 22Rv1, and LNCaP clone FGC cell lines, respectively. In the antioxidant test, the IC50 of AuNPs and BHT against DPPH free radicals were 205 and 162 µg/mL, respectively.

Evaluation of compost prepared from Prosopis and Alhagi plants as a medium and fertilizer for seedlings, growth and yield of tomato

For clean a agriculture and a safe environment, this study was conducted, which included the preparation of a compost from Prosopis fracta and Alhagi maurorum plants, and evaluation Its as a medium for tomato seedlings production comparing it with peat moss, and as an organic fertilizer in comparison with a number of organic fertilizers - poultry wastes, cow with sheep wastes and spent mushroom compost residues, the results showed the superiority of the prepared compost over the peat moss in the speed and percentage of germination, plant height, and dry vegetative weight of tomato seedlings with a percentage increase of these traits amounted to 27.27%, 8.13%, 52.46% and 33.20%, respectively.. The results of evaluating compost as an organic fertilizer showed that the two treatments of poultry and compost were superior to mushroom residues, the mixture of cow and sheep manure in chlorophyll content, dry vegetative weight and fruit yield, as the chlorophyll content reached 52, 51, 48 and 50 SPAD, the dry vegetable weight of 776, 761, 633 and 643 g plant-1, the total yield of fruits 11.6, 11.1, 6.6 and 8.3 kg plant-1. The results of chlorophyll, dry vegetative weight of plants and total fruit yield of the combination of organic fertilizers - poultry wastes, compost, mushroom residues, and mixture of cow and sheep wastes- with 1/2 amount of chemical fertilizer NPK amount of 66 , 64, 57, 63 SPAD, 1125, 1123, 1076 and 1081 gm plant-1, 15.8, 15.7, 14.9 and 15.3 kg plant-1 respectively.

Extraction, purification, and characterization of polysaccharides from Alhagi pseudoalhagi with antioxidant and hypoglycemic activities

Alhagi pseudalhagi is a well-known herbal remedy in traditional medicine. The current study aims to isolate and characterize the polysaccharides of A. pseudalhagi, as well as assess their antioxidative and hypoglycemic effects in vitro. Using DEAE-52 and Sephadex G-100 chromatographic columns, obtained one neutral (APs-1) and two acidic (APs-2, APs-3) polysaccharides. HPGPC, GC–MS, UV, FT–IR, Congo red, CD, and SEM analyses were used to characterize their physicochemical properties. The major monosaccharides in APs-1 and APs-2 were rhamnose, mannose, glucose and galactose, while in APs-3 was only rhamnose and galactose. They were heteropolysaccharides with average molecular weights of 57.8 kDa, 630 kDa, and 707 kDa, respectively. All three polysaccharides were in α-glycosidic linkage and had a triple-helical conformation with varying degrees of asymmetry. APs-1and APs-2 exhibited relatively loose, curly, honeycomb-like texture, whereas APs-3 was cross-linked filamentous with a smooth surface. In vitro, all three polysaccharides demonstrated remarkable antioxidant effects on the DPPH and ABTS radicals, with, APs-3 demonstrating excellent α-glucosidase inhibiting capacity of the three polysaccharides. showed better ABTS scavenging and α-glucosidase inhibiting capacity compared to APs-1 and APs-2. These findings suggest that A. pseudalhagi polysaccharides have the potential to act as an antioxidant and a hypoglycemic agent.

Formulation and Evaluation of Herbal Gel of Alhagi Camelorum with its Anti-inflammatory Activity

This paper emphasizes the anti-inflammatory effects of Alhagi Camelorum. Most of the diseases are caused by a continuous swelling, including cancer. There is hence a need to neutralize inflammation. A. Camelorum, a medicinal plant, has been historically utilized as a remedy in Ayurveda and other systems of folk medicine. Thus, several techniques were utilized by Wister rats to examine A. Camelorum anti-inflammatory properties. The plant material was crushed into a coarse powder in a grinder after drying and stored at a room temperature for further investigation. The powdered plant material of A. Camelorum was subjected to successive solvent extraction (hexane, petroleum ether, chloroform, and methanol) in soxlet extraction method. Different extracts were analyzed using a traditional procedure to evaluate the various physicochemical properties. The HPTLC report is included to the file. It was discovered that the methanol and chloroform drug extract contained flavonoids (good anti-inflammatory properties) when quercetine was used as a marker. Topical gel of methanol and chloroform drug extract of A. Camelorum were prepared with Carbopol 934, hydroxypropyl methylcellulose (HPMC) and carboxymethyl cellulose. These gel formers have been created, tested, and gel chosen, which showed good propagation and consistency, to get the right consistency of the gel formulation. Gel containing methanol drug extract FM2 and FM10 formulation showed highest in-vitro release which were selected and subjected to carrageenan induced rat paw edema method. Our study reveals the anti-inflammatory effects of methanol extract of A. Camelorum were found to be significant.

Morphoanatomical study of some species from fabaceae family in Iraq

The current study dealt with comparative morphological and anatomical study of different species of Leguminosae family in Iraq. The study included seven species : Albizia lebbeck Benth. , Alhagi maurorum Medik. , Cassia sopheral Roxb. , Leucaena leucocephala Lam. , Medicago sativa Boiss., Trifolium repens Boiss, Vicia tenuifolia Roth. .The morpho-anatomical study is very important to distinguish between them. Samples of the study were collected from different areas in Iraq during flowering period between 2021-2022. In the present research, cuticular and epidermal anatomical features were described, in addition to the anatomical features of stems, leaves and petiole. Results showed that some of the morphological and anatomical characters of studied parts have good taxonomic value to distinguish between above studied species. Epidermis characters have taxonomic significance , espeically the nature of anticilinal walls and types of stomatal complexes , while dimensions of stem cells and the rates of the length of stomata were limited taxonomic importance . The general shapes of cross – sections of stem showed great taxonomic significance for isolation species , as well as cortex thickness .

Comprehensive cadastral assessment of the botanical diversity in the regions of Kazakhstan as a scientific basis for the effective use of plant resource potential

The Almaty region is one of the most economically developed regions of the Republic of Kazakhstan, where cadastral assessment has not been carried out so far. A comprehensive cadastral assessment was undertaken for the first time within the framework of the scientific and technical program (2021-2023) which takes into account the most important components of biological diversity (flora, vegetation, plant resources), sustainable use, conservation and reproduction of phytogenetic resources of the Almaty region. As a result of research in 2021 on the territory of 7 administrative districts of the region, an annotated list of flora of higher vascular plants (2414 species), algae (377 species and varieties), mycobio-ta (1266 species of micromycetes and 356 species of macromycetes) was compiled. A phytocenotic assessment was carried out on the basis of 144 geobotanical descriptions, a list of plant communities was compiled, grouped into 6 types of vegetation. The stocks of fresh raw materials for 8 species of economically valuable plants have been identified. Operational stock form 4 species: Juniperus pseudosabina, Rumex tianschanicus, Berberis sphaerocarpa, Alhagi pseudalhagi. Locations and maps of 14 rare species and 19 rare communities have been determined. Locations of 29 alien plants, including 4 invasive species, have been identified. 25 forms of the Sievers apple tree and 26 forms of the common apricot of high value for breeding were selected.

Gastroprotective effect of Alhagi maurorum (camel thorn) in ethanol-induced gastric damage in mice

Background: Alhagi maurorum is a medicinal plant found in different regions of the world including the eastern part of Libya.
 Aim: It is widely used in liver diseases with its hepatoprotective activity but its effect as an anti-ulcerogenic is not known locally. This study was undertaken to investigate the anti-ulcer effect the Alhagi maurorum has.
 Methods: A camel thorn extract (CTE) was prepared and administered to a group of mice for five days before they received ethanol to induce gastric ulcers. Comparable groups were a negative control group of mice that received normal saline and a positive control group of mice that received ethanol. The histopathological study of all stomachs was performed and graded according to the lesion scoring system.
 Result: Statistically, the mice that received CTE showed a significant improvement in the lesion score as compared to the animals that received ethanol.
 Conclusion: We conclude the Alhagi maurorum has gastroprotective activity against ethanol-induced gastric ulcers.

Evaluation of the hepatoprotective activity of hydroalcoholic extract of Alhagi camelorum against valproic acid-induced hepatotoxicity in rats.

Despite many liver disorders, clinically useful drugs are scarce. Moreover, the available therapies are facing the challenges of efficacy and safety. Alhagi camelorum has been used in folk medicine globally for millennia to treat several ailments. Alhagi camelorum (Ac) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. Our goal was to determine the hepatoprotective activity of Alhagi camelorum against valproic acid induced hepatotoxicity using an animal model. The animals were segregated in 4-groups (6 male rats each) weighing 250-290g. Group-1 animals were treated with normal saline, Group-2 animals were treated with VPA at the dose of 500mg/kg i.p for 14 days consecutively, while Group-3 and 4 were treated with valproic acid (VPA) at the dose of 500mg/kg i.p for 14 days along with 400mg/kg and 600mg/kg of Ac hydroalcoholic extract respectively. Subsequently, blood serum samples and liver tissues were collected for biochemical and histopathological analysis. Phytochemical screening was carried out to screen for phytochemical classes and HPLC analysis was conducted to screen polyphenols. The antioxidant activity was carried by different assays such as DPPH, SOD, NO etc. KEY RESULTS: The administration of Ac showed hepatoprotection at the doses of 400 and 600mg/kg. Ac significantly reduces the elevated serum levels of liver biomarkers compared to the valproic acid-induced hepatotoxic group. These findings were confirmed with histopathological changes where Ac was capable of reversing the toxic effects of valproic acid on liver cells CONCLUSION: It is concluded that Ac showed significant hepatoprotective effects at different doses in the animal model used in this study.

Effect of Alhagi maurorum distillate on ureteral stone expulsion: A single-blind randomized trial

IntroductionThe aim of this trial was to examine the effect of Alhagi maurorum distillate on ureteral stone expulsion. MethodsA randomized, single-blind, clinical trial was conducted on patients suffering from renal colic. The patients were assigned to control and intervention groups. The patients in the control group received routine treatment while the patients in the intervention group received 150 cc Alhagi maurorum distillate in three doses every day in addition to routine treatment. The duration of treatment was four weeks in both groups. Cox regression was used to assess the effect of the intervention on time of stone excretion. ResultsOne hundred and ten patients (75 men and 35 women) were included according to the inclusion and exclusion criteria. No significant difference was found in demographic characteristics and stone size and location between intervention and control groups. Time of removal was significantly shorter in the intervention group (HR = 5.12, P < 0.001) based on an adjusted model. ConclusionThe results suggest that depending on the size and location of the stone, Alhagi maurorum distillate may have a positive effect on the rate of stone removal from the ureter.

STUDY THE ANTIFIBROUS EFFICACY OF PLANT PROANTHOCYANIDIN IN RATS WITH CHRONIC HELIOTRINE LIVER DAMAGE

Under experimental conditions, the effect of plant proanthocyanidin – yantacin isolated from a camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis was studied. The studies were conducted on male rats with a body weight of 100 ±10 g. The effect of yantacin on the general and biochemical parameters of the blood, as well as the amount of NO – nitrates (in connection with lipoproteins), proteins in the blood against the background of heliotrine liver damage was studied. At the same time, yantacin demonstrated a significant protective effect compared to the control group on the detected fibrosis, according to which certain indicators, against the background of chronic toxic liver damage. In this regard, a more extensive in-depth study of the effect of the studied substance plant proanthocyanidin on normal and impaired liver activity is carried out.

STUDY THE EFFECT OF YANTACIN ON SOME INDICATORS OF CELLULAR RENEWAL AND ON THE LEVEL OF PROTEIN EXPRESSION ON RAT HEPATOCYTES IN CHRONIC HELIOTRINE LIVER DAMAGE

The effect of plant proanthocyanidin – yantacin isolated from the camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis in experimental conditions was studied. The studies were conducted on male rats with a body weight of 100 ±10 g. The effect of yantacin on the general and biochemical parameters of blood, as well as on p53, PCNA of liver tissue, mitotic and apoptotic index against the background of heliotrine liver damage was studied. As a result of the conducted studies, yantacin demonstrated a significant protective effect compared with the control group on the detected fibrosis, according to which certain indicators, against the background of chronic toxic liver damage. In this regard, a more extensive in-depth study of the protective and restorative effects of the studied plant proanthosianide substance on chronic changes in the liver, serious structural and functional disorders is being carried out.