Abstract
ABSTRACTA human parechovirus (HPeV), CH-ZXY1, was detected in feces from a child with diarrhea. Phylogenetic trees over three different genomic regions revealed discordant topological structures. Recombination analysis indicates that CH-ZXY1 is a recombinant resulting from recombination between HPeV5 and HPeV1, which was confirmed by PCR covering the recombination breakpoint.
Highlights
Human parechovirus (HPeV) belongs to the Parechovirus genus of the Picornaviridae family, which include nonenveloped, positive-sense RNA viruses with icosahedral capsids [1,2,3]
From January to December 2014, a total of 100 fecal samples were collected from children Ͻ 6 years of age with acute diarrhea who were treated as outpatients or hospitalized at the Affiliated Hospital of Jiangsu University
A BLASTn search in GenBank showed that the compete genome of CH-ZXY1 shared the highest sequence similarity of 84% to an HPeV5 strain (JX050181), and 76% to 84% to the other HPeV genomes available in GenBank
Summary
Human parechovirus (HPeV) belongs to the Parechovirus genus of the Picornaviridae family, which include nonenveloped, positive-sense RNA viruses with icosahedral capsids [1,2,3]. From January to December 2014, a total of 100 fecal samples were collected from children Ͻ 6 years of age with acute diarrhea who were treated as outpatients or hospitalized at the Affiliated Hospital of Jiangsu University. The 100 fecal samples were prepared into 10 sample pools and subjected to viral metagenomic analysis [9, 10]. One library contained 18,823 sequence reads showing sequence similarity to HPeVs, which could be assembled into a nearly complete genome.
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