The clinical efficacy of tiotropium bromide combined with azithromycin in the treatment of elderly patients with chronic obstructive pulmonary disease and its effects on pulmonary function

Abstract

Objective To investigate the clinical curative effect of tiotropium bromide combined with azithro -mycin in the treatment of elderly patients with chronic obstructive pulmonary disease （ COPD） and its effect on lung function.Methods 100 senile COPD patients were randomly divided into the two groups ,50 cases in each group.The control group was given tiotropium therapy , while the observation group used tiotropium bromide combined with azithromycin.The clinical efficacy and pulmonary function indices were compared between the two groups .Results Borg score and 6min walking distance （6MWD） of the observation group after treatment were （2.31 ±0.17） points and （380.13 ±15.07）m,which were significantly better than （3.17 ±0.26）points,（270.41 ±13.03）m of before treatment and （2.84 ±0.25）points,（320.18 ±14.78）m of the control group （t=6.84,8.56,7.90,8.73,7.79, 8.21,all P〈0.05）;FVC,FEV1 and FEV1/FVC of the observation group after treatment were （2.54 ±0.44） L, （2.13 ±0.35）L and （72.38 ±5.61）%,which were significantly higher than （1.63 ±0.37）L,（1.24 ±0.24）L and （47.30 ±5.48）%before treatment and （2.18 ±0.39） L,（1.69 ±0.35） L and （61.66 ±5.32）% of the control group （t=6.35,7.76,7.02,8.04,7.14,7.95,6.91,7.41,7.60,all P〈0.05）.Conclusion Tiotropium bromide combined with azithromycin has significant curative effect in the treatment of senile COPD and can obviously improve the pulmonary function of patients ,which has good clinical application value . Key words: Pulmonary disease, chronic obstructive ; Pulmonary function; Tiotropium ; Azithromycin; Aged