The observation of the effect of Pulmicort Respules combined with Tiotropium Bromide in the treatment of COPD and its influence on inflammatory cytokines

Abstract

Objective To observe the effect of Pulmicort Respules combined with Tiotropium Bromide in the treatment of chronic obstructive pulmonary disease (COPD) and its influence on inflammatory cytokines.Methods 130 COPD patients which met inclusion criteria were randomly divided into the observation group (65 cases) and control group (65 cases).Both two groups were given conventional therapy,the control group was given a separate aerosol inhalation of Pulmicort Respules,the observation group was inhaled Tiotropium Bromide on the basis of the control group.Both two groups were treated for 14d,the symptoms and signs were observed before and after treatment.The respiratory function and blood gas were monitored,and induced sputum was used to determine inflammatory cytokines levels of airway.Results (1) After treatment,the FEV1,FEV1/predicted,FEVi/FVC,PaO2 of the observation group were significantly increased,the PaCO2 was significantly reduced,but FEV1/FVC of the control group had no significant change after treatment.(2) The lung function and blood gas between the two groups had no statistically significant differences before treatment.After treatment,the FEV1,FEV1/predicted,FEV1/FVC,PaO2 of observation group were obviously higher than those of the control group,PaCO2 was significantly lower than the control group.(3) After treatment,the IL-8,TNF-α,neutrophil cell ratio of two groups were significantly lower than before treatment.(4) The IL-8,TNF-α,neutrophil cell ratio had no statistically significant differences before treatment between two groups.After treatment,the IL-8,TNF-α,neutrophil cell ratio of observation group were significantly lower than control group.Conclusion Pulmicort Respules combined with Tiotropium Bromide in the treatment of COPD can be targeted to the lesion site,and relieve symptoms,reduce airway inflammation,improve pulmonary function,the effect was better than simplely use Pulmicort Respules. Key words: Pulmicort Respules; Tiotropium Bromide; Atomization; COPD; Inflammatory cytokines; Clinical application