Effects of bisoprolol combined with tiotropium bromide on serum inflammatory factors and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease

Abstract

Objective To investigate the effect of bisoprolol combined with tiotropium bromide on serum inflammatory factors and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty-eight cases of AECOPD patients were divided into observation group and control group, each group of 34 cases.All patients were given conventional symptomatic treatment.The control group was treated with tiotropium bromide inhalation.The observation group in the control group on the basis of bisoprolol treatment.The pulmonary function indexes and inflammatory factors were compared between the two groups before and after treatment.The patients were assessed by the chronic obstructive pulmonary disease (COPD) evaluation questionnaire (CAT).6 minutes walking distance (6MWD) was used to measure the exercise endurance. Results The total effective rate of the observation group (91.18%) was significantly higher than that of the control group (67.65%). The difference was statistically significant (P<0.05). After treatment, the levels of hs-CRP, IL-17 and IL-23 in the two groups were significantly lower than those before treatment (P<0.05). After treatment, the hs-CRP, IL-17 and IL-23 in the observation group were significantly lower than those in the control group.The difference was statistically significant (t=4.216, 3.153, 2.240, P<0.05). After treatment, the levels of FEV1, PEFR, FEV1/FVC and 6MWD were significantly increased in two groups, and the CAT score was significantly lower (P<0.05). After treatment, the FEV1, PEFR, FEV1/FVC and 6MWD in the observation group were significantly higher than those in the control group, and the CAT score was significantly lower than that in the control group.The difference was statistically significant (t=4.115, 4.663, 8.078, 5.442, 3.331, P<0.05). Conclusions Bisoprolol combined with tiotropium bromide can significantly improve the pulmonary function of patients with AECOPD, and reduce the inflammatory response. Key words: Bisoprolol; Tiotropium bromide; Acute exacerbation of chronic obstructive pulmonary disease; Pulmonary function; Inflammatory response