Abstract
Objective To investigate the effect of propofol used in mechanical ventilation patients in the exacerbation of chronic obstructive pulmonary disease(COPD). Methods 35 patients who received mechanical ventilation and sedated by propofol were observed in the exacerbation of COPD. The time to get Ramsay sedation level Ⅲ～Ⅳ was observed. The parameters of pneusis and eirculation before ,after giving propofol and withdrawl were compared.Results The sedative time of propofol was (51.3±3. 80) seconds. In the most time(85% ) ,the level of Ramsay sedation was maintained at Ⅲ～Ⅳ after the usage of propofol. The time of awake from anesthesia was (5.8±4. 9) minutes, and the patients had no adverse reactions. The blood pressure, heart rate of patients were stable. And the parameters of respiratory rate,SaO2 ,arterial partial pressure of oxygen and partial pressure of carbon dioxide in artery were improved significantly( P＜0. 05 ). Conclusion The sedative effect of propofol is safe and effective in patients required mechanical ventilation in the exacerbation of COPD. Key words: Propofol; The exacerbation of chronic obstructive pulmonary disease; Ventilators
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