Naloxone and noninvasive ventilator in treatment of AECOPD complicated with type II respiratory failure

Abstract

Objective To observe the clinical effect of naloxone and noninvasive ventilator in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with type Ⅱ respiratory failure. Methods 82 patients with AECOPD complicated with type Ⅱ respiratory failure treated from March, 2016 to February, 2017 were selected and divided into two groups by random number table, 41 cases for each group. The control group were routineky treated, while observation group were treated with naloxone and noninvasive ventilator. The clinical efficacy, adverse reactions, and changes of blood gas indexes in the two groups were observed. Results The total effective rate and the incidence of acute exacerbation were better in the observation group than in the control group (97.56% vs. 78.05% and 19.51% vs. 46.34%) (P 0.05). Before the treatment, there were no statistical differences in partial pressure of carbon dioxide (PaCO2), arterial oxygen pressure (PaO2), power of hydrogen (pH), heart rate, and respiratory rate between the two groups (all P>0.05). After the treatment, the PaO2 and pH were higher while PaCO2 was lower in the observation group than those in control group [(95.35±4.32)mmHg vs. (86.35±10.28)mmHg, (7.38±0.06) vs. (7.31±0.09), and (43.46±5.92)mmHg vs. (51.36±8.41)mmHg, all P<0.05]. Conclusion Naloxone and noninvasive ventilator in the treatment of AECOPD complicated with type Ⅱ respiratory failure is effective and safe and can improve the patients’ blood gas indexes and adverse symptoms and decrease the incidence of acute exacerbation. Key words: Chronic obstructive pulmonary disease; Acute exacerbation; TypeⅡ respiratory failure; Naloxone; Noninvasive ventilator