The effect and prognosis of noninvasive positive pressure ventilation for the treatment of acute exacerbation of chronic obstructive pulmonary disease with pulmonary encephalopathy

Abstract

Objective To explore the treatment effect and prognosis of BiPAP non-invasive ventilator of sequential mechanical ventilation for the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with pulmonary encephalopathy,and to provide the basis for clinical therapy. Methods According to the digital table,62 AECOPD patients with pulmonary encephalopathy were selected and randomly divided into the two groups.And 30 cases in the control group received routine treatment,and 32 cases in the observation group received BiPAP non-invasive ventilator sequential ventilation.The partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2)and oxygen saturation(SaO2)before and after treatment,the changes of heart rate,respiratory rate and average arterial pressure of the two groups and the improvement time were observed. Results PaO2 and SaO2 of the two groups after treatment were higher than those before treatment(t= 12.30,10.37,11.42,13.71,all P<0.05).PaO2 and SaO2 of the observation group after treatment were(77.14±4.16)mm Hg and(90.37±2.04)%, which were higher than the control group after the treatment(72.96±3.22)mm Hg and(85.80±1.96)%(t= 6.58,7.14,all P<0.05).PaCO2 of the two groups after treatment was lower than that before treatment(t= 9.25,10.22,all P<0.05).PaCO2 of the observation group after treatment was(50.12±2.86)mm Hg,which was lower than that before treatment(54.27±3.01)mm Hg(t= 6.29,P< 0.05).The heart rate,respiratory rate and mean arterial pressure of the control group and the observation group after treatment were lower than before treatment(t= 10.11,9.43,8.66,11.28,8.56,9.15,all P< 0.05).The heart rate,respiratory rate and mean arterial pressure of the observation group after treatment were(76.52±4.35)times/min,(20.35±1.08)times/min and(83.26±3.07)mm Hg,which were lower than those of the control group after treatment(t= 6.44,5.82,6.70,all P< 0.05).The blood gas improvement time,ventilation time and hospitalization time of the observation group were(4.06±1.17)d,(4.53±0.90)d and(16.18±2.20) d, which were lower than the control group(t= 6.13, 7.05, 5.97, all P< 0.0 5). Conclusion The BiPAP non-invasive ventilator sequential ventilation for the treatment of AECOPD with pulmonary encephalopathy has good treatment effect,which can improve the difficult ventilation of patients,avoid hypoxia and CO2 retention,shorten treatment time. Key words: Ventilators,mechanical; Pulmonary disease,chronic obstructive; Brain diseases