A comparative study of the effects of different sedation methods on patients with acute exacerbation of chronic obstructive pulmonary disease

Abstract

Objective To investigate effects of different sedation methods on the mechanical ventilation patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 101 patients with mechanical ventilation in our hospital was randomly divided into observation (58 cases) and control (43 cases) groups. The observation group was given to strengthen psychological care during the day, and the night was given to the patients with AECOPD. The control group was treated with continuous analgesia and sedation, and the daily morning was executed to wake up the plan 1~2 hours. A set of indexes were observed, including white cell count, C-reactive protein, oxygen index, B-type natriuretic peptide, delirium occurred rate, unexpectedly drawn tube rate, and duration of mechanical ventilation. Results White blood cell number, C reactive protein, and oxygen index group in the observation group were significantly better than the control group[(10.1±2.4)×109/L vs (11.2±2.8)×109/L, (40.6±11.6) mg/L vs (45.8±12.2) mg/L, and (285.6±45.1) vs (268.2±42.6)](P 0.05). Conclusions The night program sedation program can significantly improve AECOPD mechanical ventilation in patients with inflammatory index and oxygen index, reduces the incidence of delirium in patients with acute exacerbation of chronic obstructive pulmonary disease, does not increase the accidental extubation rate, and significantly shortens the AECOPD patients with mechanical ventilation duration of mechanical ventilation, as a mechanical ventilation in AECOPD patients who killed one of the options. Key words: Analgesia/MT; Pulmonary disease, chronic obstructive; Respiration, artificial