Host response modulation in periodontology and implantology: potential of anti-inflammatory, antibacterial therapy and promising dosage forms. Review

Abstract

Relevance. Immunological disorders play a key role in the pathogenesis of inflammatory periodontal diseases. The importance of autoimmune aggression in the process of implant rejection is recognized too. Some methods of host response modulation are already widely used in clinical practice, other are recently proposed. There is a constant search for new pharmaceutical products that can normalize body’s immune reactions and stimulate regeneration processes. Purpose . To study modern views on the place of immunopathology in the concept of pathogenesis of periodontal diseases, methods of modulation of the immune response, to systematize the literature devoted to this problem. Materials and methods. A review of the literature on the topic of 80 sources from them 10 domestic and 70 foreign date. Results. The literature review summarizes and presents modern methods of host response modulation. Conclusion. Development and implementation of methods of host response modulation is a promising direction of development of modern periodontics.