Abstract
Objective To study the effect of radical resection combined with antiviral therapy on hepatitis B virus infection. Methods From January 2012 to January 2016, 46 patients with hepatocellular carcinoma complicated with hepatitis B virus infection in the First People's Hospital of Jiashan County were enrolled in this study.All the subjects included in this study had complete clinical data and were willing to cooperate with this study.According to the random number table method, the patients were divided into two groups, with 23 cases in each group.The two groups were all treated by radical resection, the control group was not given anti-viral treatment after operation, the study group was given anti-virus combination therapy after surgery.The patients were followed up for more than 1 year.The levels of liver function[alanine aminotransferase (ALT), serum albumin (ALB), prealbumin (PA)]and hepatitis B virus (HBV-DNA) were measured before and after operation in both two groups.The incidence rate of postoperative complications, length of hospital stay, medical expenses and recurrence rate were analyzed. Results There were no statistically significant differences in ALT, ALB, PA and HBV DNA between the two groups before operation (all P>0.05). There were statistically significant differences between the two groups after operation[ALT: (97.74±33.27)U/L vs.(142.98±53.41)U/L, t=3.447; ALB: (34.57±5.01)g/L vs.(38.44±4.32)g/L, t=2.805; PA: (192.14±53.24)mg/L vs.(159.85±53.96)mg/L, t=2.042; HBV-DNA: (4.25±1.04)logcopes/mL vs.(6.22±1.18)logcopes/mL, t=6.006, all P 0.05). Conclusion Hepatocellular carcinoma with hepatitis B virus infection in patients with radical resection and anti-virus combination therapy, can better improve the patients' liver function and viral indicators, shorten the hospital stay, reduce medical costs, and can reduce the incidence of complications, with high safety. Key words: Liver neoplasms; Hhepatitis B virus; Hepatectomy; Antiviral agents
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