Clinical risk factors of chronic hepatitis B virus infection in patients with gestational diabetes

Abstract

Objective To analyze the clinical risk factors of chronic hepatitis B virus infection in patients with gestational diabetes, and to improve the pregnancy outcomes of such patients. Methods A total of 493 pregnant women who received pregnancy tests and were hospitalized from February, 2016 to February, 2018 were selected as observation objects. Among them, 229 pregnant women without hepatitis B virus infection were included in the test group A, 38 pregnant women with chronic hepatitis B virus infection were set as test group B, and 226 healthy pregnant women were set as a control group. The clinical data of the 493 pregnant women were recorded and statistically analyzed in a retrospective survey. The three groups’ pregnancy outcomes were carefully recorded and compared. The clinical risk factors for chronic hepatitis B virus infection in gestational diabetes patients were analyzed. Results There were no statistical differences in the incidences of cesarean section, postpartum hemorrhage, premature delivery, neonatal asphyxia, etc. among the three groups (all P>0.05). The incidences of intrahepatic cholestasis, acute chorioamnionitis, fetal distress, and macrosomia was significantly higher in the test group B than in the test group A and the control group. Among the 493 pregnant women, 38 patients with gestational diabetes mellitus had chronic hepatitis B virus infection, and the infection rate was 7.70%. Smoking history, drinking history, HBsAg, ALT, GGT, etc. had significant effects on the incidence of chronic hepatitis B virus infection, and the differences were statistically significant (all P<0.05). Conclusions Smoking history, drinking history, HBsAg, ALT, GGT, etc. are clinical risk factors for chronic hepatitis B virus infection in patients with gestational diabetes. Therefore, the patients should cultivate good living habits and take reasonable and appropriate diet, appropriate moderate exercise, safe and effective control of blood glucose, and antiviral therapy, so as to improve pregnancy outcomes. Key words: Gestational diabetes mellitus; Chronic hepatitis B virus infection; Clinical risk factors