Abstract

Objective To investigate the influence of hepatitis B virus (HBV) infection on liver function in acute lymphoblastic leukemia (ALL) patients after chemotherapy. Methods Among the 247 ALL patients, the biomarkers of HBV were detected by ELISA, the copies of HBV-DNA were determined by real-time polymerase chain reaction (PCR), and the liver function indexes were determined by biochemical analysis. Results Fourteen out of 247 ALL patients (5.67%) were HBsAg-positive, and the liver function in 9 cases(64.29%) out of 14 ALL patients infected with hepatitis B virus were abnormal within one course of chemotherapy (28 days). The increase of ALT was(198.75±290.88) U/L, and the increase of ALP was (44.00±117.38) U/L.The liver function in 87 out of 233 ALL patients (37.34%) without hepatitis B virus infection were abnormal within one course of chemotherapy(28 days). The increase of ALT was (46.49±100.02) U/L, and the increase of ALP was (22.68±87.14) U/L.The HBV-DNA copies were increased more than 2log10UI/ml in one patient infected with hepatitis B virus (HBV). Conclusions The liver function of HBsAg+ ALL patients were more common to be injured than HBsAg-ALL patients within one course of chemotherapy, and the liver function is more serious injured in HBsAg+ ALL patients.Chemotherapy may reactivate hepatitis B virus in ALL patients. Key words: Acute lymphoblastic leukemia; Hepatitis B virus; Liver injury

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