Abstract
The method of determination of the dielectric constant of individual erythrocytes, based on a quantitative analysis of the profiles of their images obtained by electrostatic force microscopy, is presented. A model of electrostatic interaction between the atomic force microscope probe and the biological cell is proposed. The obtained values of the permittivity of individual erythrocytes agree well with known literature data.
Highlights
The electrical properties of cells investigate generally by measuring a response of cells on external electric field [1]
red blood cells (RBC) were separated by centrifugation of whole blood, and thrice washed with isotonic solution
The highly oriented pyrolytic graphite (HOPG) surface with immobilized RBC was scanned by atomic force microscope MFP-3D SA (Asylum Research) by electrostatic force microscopy (EFM)-method at various applied voltages
Summary
The electrical properties of cells investigate generally by measuring a response of cells on external electric field [1]. The electric response depends on the shape, size, internal structure and conductivity of cell, and susceptibility of cellular components. It should be noted that the registration of response is usually performed on large cell populations that leads to average of measured parameters.
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